New preprint from the lab, led by the ever-talented grad student Tessa Lochetto @tlochetto.bsky.social! We find that loss of our favorite phosphatase Pptc7 decreases lean mass, induces skeletal muscle dysfunction, and causes metabolic derangements in adult mice: doi.org/10.64898/202... /1

Sustained loss of Pptc7 triggers variable skeletal muscle dysfunction and diminished body mass through dysregulation of BNIP3

The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and perinatal lethality in mice. However, the extent to w...

doi.org

🚨We are #hiring! Excited to welcome a talented #postdoc to join the lab. and be part of an interdisciplinary research program #Type1DiabetesGrandChallenge -- harnessing #pancreas #development for #stem cell therapy of #diabetes. 🧫🧪🔬 Join us! Apply before 23 July. ⤵️ my.corehr.com/pls/coreport...

Excited to share our new preprint! The derlin Dfm1 promotes Ste24-dependent translocon quality control! I'm so proud of the many master's, undergrad, & high school students who contributed to this project over many yrs. Very grateful to collab w/ Robb Tomko! (1/4) www.biorxiv.org/content/10.6...

Dfm1 promotes Ste24-dependent translocon quality control

Proteins stalled during endoplasmic reticulum translocation clog Sec61 channels and require translocon quality control (TQC) mechanisms for clearance. Genetic screens implicated the derlin Dfm1 in TQC...

biorxiv.org

I’m so sad to share that yesterday was my last day at Scientific American. It was an honor to work alongside my incredible colleagues and to speak with researchers across the sciences. If you’re looking to hire staff or freelance, please consider me and my other laid off coworkers (🧵)

The F1 region of ATP synthase interacts with TCA cycle enzymes. www.nature.com/articles/s41...

Investigating the relationship between ATP synthase and the TCA cycle by crosslinking mass spectrometry - Nature Communications

Mitochondria convert nutrients into ATP through coordinated molecular machines and metabolic pathways. Here, the authors show that ATP synthase contacts TCA cycle enzymes in mouse heart and that defec...

nature.com

Full open access link here: rdcu.be/fptyS

Mark Huising@huisinglab.bsky.social · 2mo ago

New paper in @diabetologiajnl.bsky.social on paracrine control of insulin secretion, led by the talented newly minted Dr. Ryan Hart (@ryanhart13.bsky.social). 1/5 doi.org/10.1007/s001...

When an expert on authoritarianism (@anneapplebaum.bsky.social) is writing about your scientific meeting, alarm bells should go off. Write to American Diabetes Association CEO Charles Henderson at chenderson@diabetes.org and Chief Medical Officer Rita Rastogi Kalyani at rkalyani@diabetes.org.

Anne Applebaum@anneapplebaum.wsocial.eu · 2mo ago

Senior researchers at a meeting of the American Diabetes Association were handing out copies of an editorial, published in the association's journal, condemning Trump administration cuts to diabetes research. Police came to arrest them. www.nytimes.com/2026/06/05/w...

Metformin Redirects Autophagy from Bulk Turnover to Mitochondrial Clearance https://www.biorxiv.org/content/10.64898/2026.06.04.730191v1

Raghu Mirmira, MD, PhD, #ENDO2026 Clinical Science Chair, highlights three must-see sessions for translational clinical researchers—debates and a “meet the scientist” session. Watch now: https://bit.ly/4o2XBV2

Clinical Science at ENDO 2026 | Raghu Mirmira, MD, PhD,

Raghu Mirmira, MD, PhD, ENDO 2026 Annual Committee Clinical Science Chair, highlights sessions for Translational Clinical Researchers with three notable sessions, focusing on debates and a "meet the scientist" session relevant to translational research....

bit.ly

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction. www.biorxiv.org/content/10.6...

🚨 New paper from our lab in BMC Methods! We describe a simple, rapid, and cost-effective method to identify subcutaneously transplanted pancreatic human islet grafts using dithizone (DTZ) staining. #diabetes #stemcells #islets 🧵 link.springer.com/article/10.1...

Optimizing post-transplantation detection of subcutaneously transplanted islets using dithizone staining - BMC Methods

BMC Methods - Pancreatic islet transplantation is a promising therapeutic strategy to restore insulin independence in patients with type 1 diabetes mellitus. In addition to primary human islets,...

link.springer.com

Islet amyloid formation upregulates StAR expression in beta cell mitochondria, leading to mitochondrial dysfunction and increased cell death #Islets #BetaCells #Mitochondria #DiabetesResearch link.springer.com/article/10.1... 🔓

Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells - Diabetologia

Aims/hypothesis Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits...

link.springer.com

NEW: A serious staffing shortage — of the Trump admin's own making — is delaying the agency's ability to send billions to universities around the country, leaving labs reeling in the meantime. “I thought we were at rock bottom”, a senior NIH official said. “We are below rock bottom now.”

NIH staffing shortage could slash number of new grants issued this year

Some units at the US funding giant are so understaffed, they are focusing on mandated grant renewals rather than new awards.

nature.com

A survivor of the Kent State Massacre rings the bell on campus today, May 4, at exactly 12:20, the moment his classmates fell, 56 years ago.

Chen et al. provide an overview of the current landscape of human pancreatic tissue resources, coordinated phenotyping efforts and data platforms that are advancing our understanding of diabetes pathogenesis. link.springer.com/article/10.1...

From pancreas and islet resources to diabetes insights - Diabetologia

Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the de...

link.springer.com

📣 Job announcement: we have an open Postdoctoral position in the field of neural stem cell metabolism! Motivated candidates should apply through the official platform under this link, where you can also find more informations: career5.successfactors.eu/career?compa... Please help spread the word!

We are tremendously inspired by our director Mark Anderson's election to the National Academy of Sciences @nasonline.org www.nasonline.org/news/2026-na...

Science is good. We should fund it.

Our newest paper is out online! An Open-Source Code to Analyze Mitochondrial Intracellular Distribution from Fluorescence Microscopy Images Congrats @giologia.bsky.social! portlandpress.com/bioscirep/ar...

"China’s population is four times the size of America’s, and its culture is unabashedly pro-science, even relative to other developed countries." 🧪

The Shocking Speed of China’s Scientific Rise

When will Chinese research pull ahead of the U.S.’s?

theatlantic.com

Why do intrinsically disordered proteins appear larger than they are in SDS-PAGE? We investigate how sequence properties affect SDS-PAGE mobility using synthetic IDRs. Conclusion: We need to consider both SDS binding and the compaction of protein-SDS complexes. www.biorxiv.org/content/10.6...

🧬 New from Johnson et al! 📄Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes

Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes

We show that bi-allelic variants in the minor spliceosome snRNAs RNU6ATAC and RNU4ATAC cause early-onset autoimmune diabetes with immune dysregulation. We define a shared mechanism involving U12 intro...

cell.com

Insights from derivation of human IPS #stemcell derived islet-like or off-target enterochromaffin (EC)-like cells in the pancreas #diabetes www.nature.com/articles/s41...

The quiet part being illuminated: there have been very few new awards from NIH this fiscal year, for some very specific reasons 🆘 www.science.org/content/arti...

Delays in awards and funding calls worry NIH-funded researchers

Many programs may be pushed into the next fiscal year, and some could face funding gaps

science.org

🚨Dear Bluesky friends, we need your help to advance in 2026 STAT Madness, the March Madness of Science tournament! 🏀🧪 Please vote for our Univ of Michigan Caswell Diabetes Institute team in your bracket before Mon March 9. Thank you! 🙏 www.statnews.com/feature/stat...

2026 STAT Madness

2026 bracket Welcome to STAT Madness, a bracket-style contest to find the best innovation in science and medicine. Explore groundbreaking innovations from

statnews.com

A response to the opinion that private $ can replace the NIH. Businesses are not charities. They work on profit margins. Decades of $ is essential for research to progress from an initial discovery to treatment. Most of the dirty work goes on in academic labs. 🧪 www.science.org/doi/10.1126/...

Private money cannot replace public funding of science

Who should pay for American science? In the current political climate, many are looking to the private sector to compensate for cuts in public funding. At the Harvard School of Public Health—particula...

science.org

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...

NHLBI has not funded a single new R01 in FY2026 which began almost 5 months ago

Delighted to share our latest now published in @science.org, where we developed "cyborg" pancreatic organoids to trace and stimulate functional human islet cell maturation. We're excited for the potential as new tools for #diabetes research and therapy!

Implanted flexible electronics reveal principles of human islet cell electrical maturation

Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We im...

science.org

I am delighted to report that our latest paper has now been published in Science Advances: www.science.org/doi/10.1126/... In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology.