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Hamperl Lab

@hamperllab.bsky.social

We are professional DNA traffic controllers and study how transcription and replication are moving smoothly (most of the time).

10 Posts169 Follower157 Folgt
Helmholtz Munich@helmholtzmunich.bsky.social · 4mo ago

Summer School on Chromatin Biology 2026 at #HelmholtzMunich 🧬 📢 Application Deadline Extended to April 18, 2026. 👉 Further information on the programme & application process: lnkd.in/dN-xXmEr #abcam #summerschool #phd

Epigenetics at Helmholtz Munich@epihmgu.bsky.social · 4mo ago

DEADLINE EXTENDED: Summer School on Chromatin Biology. Transform your knowledge and skills with this 2 week course focusing on ATAC-seq, ChIP-seq, ChIC/CUT&RUN, CUT&Tag, and bioinformatics analyses. Aug 17 - 29 Interested? Apply by April 18 bit.ly/4bZwHHR #abcam #summerschool #phd #helmholtzmunich

Hamperl Lab@hamperllab.bsky.social · last yr.

Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉 🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression. www.biorxiv.org/cgi/content/...

Replisome progression regulates R-loop mediated transcriptional repression

Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...

biorxiv.org

Hamperl Lab@hamperllab.bsky.social · last yr.

Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.

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Epigenetics at Helmholtz Munich@epihmgu.bsky.social · last yr.

🚨Paper Alert! 👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work! 🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability. A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!

Marcel Werner@marcelwerner.bsky.social · last yr.

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇

Antonio Scialdone@antonio-scialdone.bsky.social · last yr.

How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking! www.embopress.org/doi/full/10....

Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data | Molecular Systems Biology

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

embopress.org

Hamperl Lab@hamperllab.bsky.social · last yr.

Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.

Marcel Werner@marcelwerner.bsky.social · last yr.

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇