Small contribution to the eternal match happening inside every cell: in the red corner, replication. In the blue corner, transcription. Both convinced they own the genome. Another amazing collaboration with @hamperllab.bsky.social and @luijsterburglab.bsky.social lnkd.in/ey9tH7YF

Our new paper is finally out! 📢 Great team effort from Sara M, @joanasgrmrtnz.bsky.social and @agalleg.bsky.social with the support from everyone in the lab. Many thanks to our collaborators, @andreichabes.bsky.social , @mmaslon.bsky.social and @lschermelleh.bsky.social

Slow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speed

Slowing RNAPII velocity boosts naive pluripotency, uncovering an unexpected link to cell plasticity.

science.org

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

I'm beyond excited and thrilled to share that my first (co)-first-author research paper has been published in Nature 🎉 If I say Transcription-Replication Conflict, do cilia proteins pop in your head? No? Well, understandable, but you'd be wrong! Intrigued? Then read this paper!

Luijsterburglab@luijsterburglab.bsky.social · 7mo ago

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

Happy to share I have been promoted to Full Professor of Transcription and DNA Repair! Huge thanks to all current and former Luijsterburg Lab members. Your hard work, dedication, and inspiring spirit made this possible! 💥🧬🙏 www.luijsterburglab.org

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇

Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery

Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat

academic.oup.com

Very happy to share that our work on identifying and characterizing factors affecting DNA replication is published by Nature Communications!

Haico van Attikum@haicovanattikum.bsky.social · last yr.

We present Repli-ID, an approach to identify proteins affecting DNA replication. Lge1 and Rox1 are new regulators of this process. Great work by @sophievdhorst.bsky.social, @lleonie.bsky.social and co-authors in collaboration with @andreichabes.bsky.social. tinyurl.com/mvvcp3xe

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription https://www.biorxiv.org/content/10.1101/2024.11.20.622938v1

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription https://www.biorxiv.org/content/10.1101/2024.11.20.622938v1

Independently of the pathways or circuits deregulated in cancer cells, these present altered transcr

biorxiv.org