Check out our new paper in @commschem.bsky.social, where we identified a novel enantioselective fragment for the deubiquitinating enzyme, OTUD7B. An absolute pleasure to co-lead this project with Aini Vuorinen and @cassandrakennedy.bsky.social! www.nature.com/articles/s42...

Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation - Communications Chemistry

The ovarian tumour protease (OTU) family of deubiquitinating enzymes (DUBs) are biochemically well-characterised and of therapeutic interest, however, only a few tool compounds exist to study their ce...

nature.com

Dr Cassandra Kennedy@cassandrakennedy.bsky.social · 2y ago

Happy to share our new paper, out now in @commschem.bsky.social. Was great working with Aini and @katmcphie.bsky.social on this! We used chemoproteomics and HTC to find an enantioselective hit for OTUD7B. www.nature.com/articles/s42... @katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk

Excited to see this out in Nature Communications. A great platform to profile reactive fragments against the human proteome (and beyond), quickly and accurately. #ChemBio #Chemsky

George Biggs@george-biggs.bsky.social · 2y ago

Excited to share a key part of my postdoctoral work from @crick.ac.uk and GSK, published in Nature Communications. A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems. www.nature.com/articles/s41...

Interested in a PhD combining high-throughput synthesis, structural and cell biology to understand kinases? Deadline to apply for a project with Richard Bayliss, Helen Matthews and me: January 6th! www.findaphd.com/phds/project...

Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds on FindAPhD.com

PhD Project - Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds, listed on FindAPhD.com

findaphd.com

I am happy to share that our recent work has been published in Angewandte Chemie. We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits. onlinelibrary.wiley.com/doi/full/10....

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening

Direct-to-biology workflows promise to accelerate hit optimisation for drug discovery. Here, we describe a direct-to-biology method for the efficient synthesis and screening of cysteine-reactive frag...

onlinelibrary.wiley.com

ChemBio fans please repost the #ChemicalBiology Feed bsky.app/profile/thor... @carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social #chemsky