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Hatzios Lab

@hatzioslab.bsky.social

Chemically dissecting host–microbe interactions at Yale University

11 Posts134 Follower137 Folgt
Siggy Nachtergaele@siggyn5.bsky.social · 11mo ago

Thrilled to share a new preprint from the lab! We investigated how m6A regulates the transcriptome in chemoresistant glioblastoma through unexpected mechanisms, and the potential therapeutic applications of this discovery. Check out the preprint here ⬇️ www.biorxiv.org/content/10.1...

N6-methyladenosine promotes temozolomide resistance through non-canonical regulation of mRNA stability in glioblastoma cells

N6-methyladenosine (m6A) is a critical regulator of mRNA processing and function, impacting nearly every step of the mRNA lifecycle. Changes in m6A status have been implicated in many different types ...

biorxiv.org

Cell Host & Microbe@cp-cellhostmicrobe.bsky.social · 12mo ago

One bacterium’s trash is another’s treasure Syberg & Rajakovich highlight work of @hatzioslab.bsky.social‬ discovering that two distinct species of commensal bacteria metabolize a dietary antioxidant through a cross-feeding pathway www.cell.com/cell-host-mi...

One bacterium’s trash is another’s treasure

Human gut microbes are often thought to compete with other microbes for nutrients. However, they can also work together to share resources. In this issue of Cell Host & Microbe, Zhou et al. discover t...

cell.com

Hatzios Lab@hatzioslab.bsky.social · last yr.

Congrats to @amankumar25.bsky.social and colleagues in the @agoodmanct.bsky.social lab at Yale MSI on their paper in @nature.com identifying bug–drug interactions that affect host susceptibility to enteric infection. Great story!

Andy Goodman@agoodmanct.bsky.social · last yr.

New paper! Combining epidemiology and experiments uncovers surprising drug-host-microbiome-pathogen interactions. Congrats @amankumar25.bsky.social, Robyn Tamblyn, and the rest of the team. www.nature.com/articles/s41...

Hatzios Lab@hatzioslab.bsky.social · last yr.

Thanks to the Bodossaki Foundation 🇬🇷 for a great night celebrating the achievements of Greek scientists. Congratulations to all of the honorees and to the students and postdocs who contributed to our work!

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Matt Bogyo@mbogyo.bsky.social · last yr.

Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Nature Communications

Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hy...

link.springer.com

Hatzios Lab@hatzioslab.bsky.social · last yr.

Congrats to Anna Seminara on her paper out today in @cp-cellchembiol.bsky.social reporting a new approach to metabolite depletion using a bacterial ABC transporter, applied to study the antioxidant ergothioneine in H. pylori!

Cell Chemical Biology@cp-cellchembiol.bsky.social · last yr.

Online now! An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology by Anna B. Seminara and Stavroula K. Hatzios @hatzioslab.bsky.social‬ at @yale.edu @mcdb-yale.bsky.social http://dlvr.it/TJRWKG