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Siggy Nachtergaele

@siggyn5.bsky.social

Assistant Prof @ Yale MCDB; RNA enthusiast; washed up college athlete; kid wrangler x2 (not necessarily in that order)

6 Posts331 Follower88 Folgt
Siggy Nachtergaele@siggyn5.bsky.social · 8mo ago

Pre-print #2 from the lab this year! We took a closer look at the m1A methyltransferase TRMT61B (a super interesting enzyme that targets multiple types of RNA), and explored location-dependent effects of TRMT61B-mediated m1A on mRNA translation. Led by very talented grad student, Dorthy Fang!

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation https://www.biorxiv.org/content/10.64898/2025.12.08.692954v1

David Breslow Lab@davidbreslowlab.bsky.social · 9mo ago

Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/... Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia

A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.

science.org

Yale Center for RNA Science and Medicine@yalerna.bsky.social · 10mo ago

Don't forget to join us tomorrow for the RNA Club! 🎟️ Don’t miss your chance to add a new stamp to your RNA Club card and keep the collection growing

Yale Center for RNA Science and Medicine@yalerna.bsky.social · 10mo ago

October RNA Club 🎃 Join us to explore some spooktacular discoveries in RNA. This month’s presentations feature: 🦇 Kumari Kavita Thakur (Breaker Lab) 🦇 Kyrillos Abdallah (Gilbert Lab) Come, collect the next RNA Club collectible, and celebrate RNA science that’s anything but scary

Flyer for the Yale RNA Club with a Halloween theme. The background is dark gray with decorative elements including bats, cobwebs, a witch hat, the words 'Spooky Witches,' ghosts, gravestones, spiders, black cats, and jack-o’-lanterns. Large green text at the top reads: 'Yale RNA Club.' Schedule is listed in bright green and white text: 9:00 AM – Breakfast 9:15 AM – Kumari Kavita Thakur, Breaker Lab. Talk title in italics: Ancient RNA Sensors Reveal New Guanidine Biology in Vertebrates 9:45 AM – Kyrillos Abdallah, Gilbert Lab. Talk title in italics: mRNA-specific translation initiation rates are tuned to prevent cellular stress At the bottom right, event details read: '14th October, Bass 305.' Contact information at the bottom left: 'Srikar Gopinath (srikar.gopinath@yale.edu
Siggy Nachtergaele@siggyn5.bsky.social · 11mo ago

Thrilled to share a new preprint from the lab! We investigated how m6A regulates the transcriptome in chemoresistant glioblastoma through unexpected mechanisms, and the potential therapeutic applications of this discovery. Check out the preprint here ⬇️ www.biorxiv.org/content/10.1...

N6-methyladenosine promotes temozolomide resistance through non-canonical regulation of mRNA stability in glioblastoma cells

N6-methyladenosine (m6A) is a critical regulator of mRNA processing and function, impacting nearly every step of the mRNA lifecycle. Changes in m6A status have been implicated in many different types ...

biorxiv.org

Yale Center for RNA Science and Medicine@yalerna.bsky.social · 11mo ago

Excited to share groundbreaking research from our members! Researchers, including Dr. Stephanie Halene & Dr. Diane Krause, discovered a potential treatment pathway for aggressive leukemia, making it a possible target for the development of new therapies Read more: medicine.yale.edu/news-article...

Yale Study: Potential Treatment Pathway Found for Rare and Aggressive Leukemia

A Yale study published Aug. 28 on the cover of the journal Blood explains basic scientific discoveries that could lead to innovative therapies for acute myeloid

medicine.yale.edu

Yale Center for RNA Science and Medicine@yalerna.bsky.social · last yr.

✨Hey Postdocs and ARS! Our social event is happening this Monday🎉 To help us plan food and drinks, please use the sign-up link sent through the institutional mailing list by the end of today Not on the list? Comment below to make sure you get the info Let’s start the week with new and good company

Yale Center for RNA Science and Medicine@yalerna.bsky.social · last yr.

🌟 Postdocs & ARSs🌟 New at Yale or looking to strengthen your connections? Join us for an informal Peer Support Program social on 📅Monday, March 24, 2025 🕠4:30–6:30 PM 📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹 Looking forward to seeing you there! More info on institutional email

Yale Center for RNA Science and Medicine@yalerna.bsky.social · last yr.

🌟 Postdocs & ARSs🌟 New at Yale or looking to strengthen your connections? Join us for an informal Peer Support Program social on 📅Monday, March 24, 2025 🕠4:30–6:30 PM 📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹 Looking forward to seeing you there! More info on institutional email

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Jayne, attempting irony@eyegah.bsky.social · last yr.

So, for those of us who don’t know how medical research funding works (I myself did not), this nice researcher broke it down for me.

Needhi Bhalla 💅🏽@needhibhalla.bsky.social · last yr.

when we get a grant we get two pots of money: direct costs that directly fund the research (supplies and stipends for trainees) and indirects, that provide funds for the institution to support the research (electricity for equipment, staff to administer the grants, space for the research, etc.).

Yale Center for RNA Science and Medicine@yalerna.bsky.social · last yr.

💖RNA lovers, this one’s for you!💖 RNA Club: Valentine’s Day edition Hear fantastic talks from Nachtergaele and Breaker labs, and kick off the morning with fresh, heart-shaped waffles 🧇❤️ 📅Tuesday, Feb 11 | 🕢 8:45 AM| 📍 BASS 305 Spread the word, bring a friend, and share your RNA love💕

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