Blm10 and PI31 comprise a failsafe mechanism for proteasome inhibition pubmed.ncbi.nlm.nih.gov/42485378/ #cryoEM
Harvard Cryo-EM Center for Structural Biology
@hc2em.bsky.social
Consortium formed by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital. cryoem.hms.harvard.edu
We used cryo-EM at @hc2em.bsky.social to visualize how alphaviruses bind the mosquito receptor. Lachesin binds within the cleft of adjacent E2–E1 heterodimers, which is also a site where CHIKV binds MXRA8, a receptor on human cells.
Thank you, @hc2em.bsky.social! The entire team made this possible! You are amazing.
Cryo-EM Structure of Recombinantly Expressed hUGDH Unveils a Hidden, Alternative Allosteric Inhibitor pubmed.ncbi.nlm.nih.gov/39680853/
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A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX
Our paper on the structure of the complete Rpd3S-nucleosome complex is now out in Nat Comm: rdcu.be/ds6k1 . Congrats to @jonmarkert.bsky.social and co-corresponding author Seychelle Vos! This is the second HDAC-nucleosome structure from Jon this year. Amazing!
Thrilled to announce that I have been awarded the NIH Director's New Innovator Award from NIH_CommonFund to study processes at the nexus of chromatin, transcription, and epigenetics. Thank you to my lab, former and current mentors, and the support by the Department of Cell Biology at HMS!