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Susan Shao

@sshaolab.bsky.social

Dissecting molecular mechanisms that regulate protein and cellular homeostasis. https://shao.hms.harvard.edu

17 Posts1591 Follower339 Folgt
Susan Shao@sshaolab.bsky.social · 4mo ago

Abstract deadline extended to April 20 for the FASEB #UbiqSRC, colocated with the #ProtFoldSRC, June 1-4 in Louisville! Register for one of the ~20 talk slots throughout the main meeting and pre-meeting career forum! events.faseb.org/event/Ubiqui...

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FASEB@faseborg.bsky.social · 5mo ago

The longest-running UB/UBL conference, join @labjoazeiro.bsky.social and @sshaolab.bsky.social, for #UbiqSRC. Featuring keynotes by @idikic.bsky.social of @goetheuni.bsky.social with Jeff Kelly from @scripps.edu.bsky.social. Submit your abstract and register to join us in Louisville: buff.ly/uAY0w0M

Susan Shao@sshaolab.bsky.social · 5mo ago

Check out this exciting joint Career Forum organized by and for scientists-in-training that will take place before the co-located FASEB Meetings on Ubiquitin and Protein Folding in the Cell, June 1-4, in Louisville, KY! Register for either meeting to opt in. Abstract deadline April 6.

Ubiquitin Mechanisms, Functions, and Therapeutics.

Join experts in UB/UBL signaling and protein degradation to explore breakthroughs in biology, disease mechanisms, and therapeutic development.

events.faseb.org

Dawafuti Sherpa@dawafutisherpa.bsky.social · 5mo ago

Excited to announce that FASEB Ignite Career Forum 2026 (preceding FASEB Ubiquitin Mechanisms, Functions, and Therapeutics & Protein Folding in the Cell) is open for registration! Abstract deadline - April 6, 2026 For more details - events.faseb.org/event/Protei... events.faseb.org/event/Ubiqui...

Martin Ott lab@mitolab.bsky.social · 8mo ago

Our study on the molecular function of translational activators for mitochondrial protein synthesis is published: rdcu.be/eSWxT A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social Funded by @kawresearch.bsky.social

Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation

Nature Structural & Molecular Biology - Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy,...

rdcu.be

Alan Brown@alanbrownhms.bsky.social · 9mo ago

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

HMS - Postdoctoral Fellow in BCMP, Brown Lab

We invite applicants for a postdoctoral fellow position in the Brown lab at Harvard Medical School in Boston, Massachusetts. The Brown lab uses structural, biophysical, and biochemical approaches to d...

academicpositions.harvard.edu

Keenan Lab@keenanlab.bsky.social · 10mo ago

This was a fun new collaboration using selective ribosome profiling to understand how the subunit composition of the ER translocon is tailored by the nascent chain. Congratulations to everyone involved! www.nature.com/articles/s41...

Global analysis of translocon remodeling during protein synthesis at the ER - Nature Structural & Molecular Biology

The authors use selective ribosome profiling to define how and when factors for N-glycosylation and membrane insertion engage and disengage from the core Sec61 translocation channel during biogenesis ...

nature.com

Susan Shao@sshaolab.bsky.social · 10mo ago

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

science.org

Sean Eddy@cryptogenomicon.bsky.social · last yr.

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

Harvard Med Cell Biology@harvardcellbio.bsky.social · last yr.

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

nature.com

Michael Baym@baym.lol · last yr.

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

Christopher Mims@mims.bsky.social · last yr.

Trump administration is terminating $2.7 billion in research funding to Harvard: Work on breast cancer, impact of nutrition on fertility, antibiotic resistance and hundreds of other topics all dead “It feels like the academic equivalent of nuclear war" www.wbur.org/news/2025/05...

Feds yank funds from Harvard breast cancer, fertility, antibiotics research

The Trump administration is following through on threats to terminate $2.7 billion dollars in federal grants and other funding at Harvard University, punishment for alleged antisemitism on campus. One...

wbur.org

Susan Shao@sshaolab.bsky.social · last yr.

Exactly - @embo.org RNA Meets Protein Decay was a much-needed scientific hurrah! Thanks to all the participants for the exceptional quality of presentations and active engagement! And to @pauligroup.bsky.social, Manuela, and the @impvienna.bsky.social for being amazing hosts!!

Pauli Group (posts by Andi Pauli)@pauligroup.bsky.social · last yr.

The 2nd edition of the @embo.org workshop 'RNA meets Protein Decay', this time here in Vienna @impvienna.bsky.social, came to an end. Thanks to everyone who came and contributed to the great vibe of sharing science, discussing ideas and connecting with each other!

Susan Shao@sshaolab.bsky.social · last yr.

Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!

Xin Gu Lab at DFCI/HMS@xingulab.bsky.social · last yr.

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...

Jennifer Waters@jencwaters.bsky.social · 2y ago

Join me, @talleylambert.bsky.social, @bethcimini.bsky.social, @florianjug.bsky.social & Hunter Elliott for our two week CSHL course on microscopy & image analysis starting March 24, 2025! Applications are due 1/31/25. meetings.cshl.edu/courses.aspx...

Quantitative Imaging: From Acquisition to Analysis

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu