Structure and operating principles of a monkeypox virus replisome | @nature.com www.nature.com/articles/s41...

Structure and operating principles of a monkeypox virus replisome - Nature

During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 th...

nature.com

Blm10 and PI31 comprise a failsafe mechanism for proteasome inhibition pubmed.ncbi.nlm.nih.gov/42485378/ #cryoEM

We used cryo-EM at @hc2em.bsky.social to visualize how alphaviruses bind the mosquito receptor. Lachesin binds within the cleft of adjacent E2–E1 heterodimers, which is also a site where CHIKV binds MXRA8, a receptor on human cells.

Thank you, @hc2em.bsky.social! The entire team made this possible! You are amazing.

Cryo-EM Structure of Recombinantly Expressed hUGDH Unveils a Hidden, Alternative Allosteric Inhibitor pubmed.ncbi.nlm.nih.gov/39680853/

Roses are red Violets are blue If you love Cryogenic Electron Microscopy This job ad is for you: jobs.brassring.com/1033/ASP/TG/...

A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX

Our paper on the structure of the complete Rpd3S-nucleosome complex is now out in Nat Comm: rdcu.be/ds6k1 . Congrats to @jonmarkert.bsky.social and co-corresponding author Seychelle Vos! This is the second HDAC-nucleosome structure from Jon this year. Amazing!

Thrilled to announce that I have been awarded the NIH Director's New Innovator Award from NIH_CommonFund to study processes at the nexus of chromatin, transcription, and epigenetics. Thank you to my lab, former and current mentors, and the support by the Department of Cell Biology at HMS!