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Hilgers Lab

@hilgerslab.bsky.social

RNA biology, gene regulation, nervous system function and development

12 Posts502 Follower614 Folgt
Hilgers Lab@hilgerslab.bsky.social · 2mo ago

Congratulations to the fantastic Sakshi Gorey, our newest PhD graduate! It was a particular pleasure to knit her other (less traditional, but more functional) doctoral hat. May Dr. Gorey continue shining bright in the new lab in Basel!

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Ursula von der Leyen@vonderleyen.ec.europa.eu · 9mo ago

Switzerland is joining Horizon Europe! We are uniting two research powerhouses. For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more. Today is a good day for science, and for our EU-Switzerland partnership.

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Hilgers Lab@hilgerslab.bsky.social · last yr.

New paper from our lab! Fabulous and brilliant @carlosalfonsog.bsky.social and @shimengjin.bsky.social, together with fantastic co-authors, show that the neuronal protein ELAV promotes biogenesis of circular RNAs in the brain. This happens through inhibition of forward ("classical") splicing.

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · last yr.

👀 New study: The stability of circular RNAs makes them ideal for long-lasting regulatory tasks in neurons. Researchers from the @hilgerslab.bsky.social have now identified the protein ELAV protein as a master regulator of circular RNA production in the nervous system, crucial for brain function.

Hilgers Lab@hilgerslab.bsky.social · last yr.

So excited to host my friend and former labmate @laghalab.bsky.social as a ... (drumroll) Special Guest at our institute! Mark your calendars and expect a great talk with beautiful live imaging.

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · last yr.

We are excited. Mounia Lagha will be our 1st Special Guest in 2025.🤗 📆 March 20, 1pm The Lagha lab (@igmm-montpel.bsky.social) uses live imaging to study mechanisms of transcription & translation in living embryos. Join us for an enlightening talk next Thursday. (Host: @hilgerslab.bsky.social)

Seminar announcement for a Max Planck Special Guest Seminar featuring Mounia Lagha from IGMM, France. The talk, titled 'Lighting Up the Central Dogma to Dissect How Sharp Developmental Patterns Are Established,' is scheduled for March 20, 2024, at 1:00 PM at MPI-IE, Lecture Hall in Freiburg. The Lagha lab investigates the mechanisms governing gene expression during development, focusing on the interplay between transcription and translation. They pioneered methods to study the translation of single mRNA molecules in Drosophila embryos, revealing critical heterogeneity in translation. This work has led to the discovery of translation factories and intragenic translation heterogeneity, uncovering a novel layer of variation in gene expression. To achieve a comprehensive understanding of gene expression precision, the Lagha Lab integrates transcriptional and translational regulation. They employ advanced quantitative imaging techniques to simultaneously monitor mRNA and protein dynamics in living Drosophila embryos with high spatio-temporal resolution. These observations are combined with theoretical models to formulate predictions, which are then tested through genetic and optogenetic manipulations. The lab's research aims to bridge the gap between transcription and translation, providing an integrated, multiscale view of gene expression control.