🧬 Mark your calendars! Our EMBO Workshop "Chromatin evolution from molecules to genomes" is coming to St Feliu de Guíxols (Spain), 4–7 Oct 2027 🌊 Amazing programme! #EMBOchromatinEvo meetings.embo.org/event/27-chromatin-evo Register early!

Chromatin evolution from molecules to genomes

Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

meetings.embo.org

New preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6...

When a scientific revolution happens on your doorstep. Simply spectacular.

Craig Kaplan@triggerloop.bsky.social · 4w ago

Cryo-EM peeps are living the dream www.science.org/doi/10.1126/...

We are recruiting! Wet&Dry either combined or separate. If you are excited about gene regulation, new methods in genomics and AI-based interpretation! Talk to us!

EMBL@embl.org · last mo.

There is still time to apply for the EMBL International PhD Programme! 📢 Don’t miss this opportunity to receive dedicated mentoring while doing interdisciplinary research. Research groups across EMBL are recruiting now! bit.ly/4x9Edss

Pierre Chambon was one of the driving architects of modern molecular biology, whose scientific vision transformed the understanding of gene regulation in eukaryotic cells. His passing in May 2026 represents the loss of an extraordinary scientist. www.nature.com/articles/s41...

Pierre Chambon (1931–2026) - Nature Genetics

Nature Genetics - Pierre Chambon (1931–2026)

nature.com

🎉Excited to share the latest paper from my lab, where we developed a new framework to investigate DNA methylation at single-molecule resolution using @oxfordnanopore.bsky.social (ONT) long read sequencing. Work spearheaded by a very talented student Young Jun Kim. www.biorxiv.org/content/10.6... 1/n

A Framework for Quantifying DNA Methylation Heterogeneity and Detecting Co-methylated loci from Native Nanopore Sequencing

DNA methylation is an important epigenetic mechanism involved in gene regulation. Most methods focus on analysing DNA methylation averaged from multiple reads, yet these average methylation profiles o...

biorxiv.org

Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)

A practical guide to studying genome function using single-molecule genomics

Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...

nature.com

your starter pack for Single Molecule Genomics! Why you should do it (or not) - How you should do it. Collective effort with @vram142.bsky.social @stirlingchurchman.bsky.social @naltemose.bsky.social A Stergachis M Stadler W Greenleaf @embl.org rdcu.be/PmzSEV529GRa

🧫 We’re hiring a staff/research scientist to develop new experimental approaches that capture cell state dynamics. Join us in Heidelberg, details + application here: embl.wd103.myworkdayjobs.com/EMBL/job/Hei... Closes September 30th

Laboratory Officer

The Dorrity group at EMBL Heidelberg is seeking a motivated and skilled molecular biologist to join as a Laboratory Officer. Our group uses cutting-edge single-cell genomic techniques to study how cel...

embl.wd103.myworkdayjobs.com

EMBL QBMM is back this year with an outstanding line-up! Plenty of talks will be selected from submitted abstracts, with emphasis on junior scientists and representation across diverse fields. The abstract deadline is the end of this week, so don’t miss out! www.embl.org/about/info/c...

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)

🚨Happy to share that the first part of my PhD is out on @cp-devcell.bsky.social! This has been an exciting project in the lab of @eileen-furlong.bsky.social @embl.org, studying the regulation of Pol II pausing across embryogenesis and its impact on gene expression dynamics. tinyurl.com/5n88ykk7

Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis

Using rapid SPT5 depletion, Dulja et al. uncover different molecular phenotypes at different embryonic stages. In early embryos, SPT5 depletion shifts Pol II from the pausing site to the +1 nucleosome...

tinyurl.com

A triptych of reviews on the transcription cycle @natrevmcb.nature.com 1️⃣ Initiation Chen & Xu 2️⃣ Elongation @camimoso.bsky.social @isaacfianu.bsky.social @adelmanlab.bsky.social 3️⃣ Termination Song et al. www.nature.com/articles/s41... www.nature.com/articles/s41... www.nature.com/articles/s41...

Is activation of multiple enhancers and promoters coordinated? Short answer is yes. Check full story from @mathias-boulanger.bsky.social @kasitc.bsky.social leveraging long read single molecule sequencing to address this. @embl.org www.cell.com/molecular-ce...

Inferring transcription factor activity: use ATAC-seq, reporter assays, or both? link.springer.com/article/10.1...

Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays - Molecular Systems Biology

Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...

link.springer.com

Exciting news! We've just moved into the brand new Livsvitenskapsbygningen (Life Science Building) in Oslo, with the whole @ncmbm.bsky.social! Incredible space, great views, and so many opportunities for collaboration ahead. 🧬🏢 @uio.no #LifeScience #Oslo #LVB

Very much looking forward to this! Join us!

Tineke Lenstra@tinekelenstra.bsky.social · 2mo ago

Sign up now for the EMBO meeting 'quantitative biology to molecular mechanisms'. Fantastic speaker lineup and plenty of speakers slots selected from abstracts. Submit your abstract before Sept 11!

Sign up now for the EMBO meeting 'quantitative biology to molecular mechanisms'. Fantastic speaker lineup and plenty of speakers slots selected from abstracts. Submit your abstract before Sept 11!

EMBL Events@events.embl.org · 2mo ago

You only have until 11 Sep to submit your abstract for #EMBOomics! ➡️ s.embl.org/omx26-01-bl Join us to discuss the latest developments in the field with leaders in genomics, dynamic proteomics, quantitative imaging, and synthetic biology.

This is an outstanding meeting across fields. The lineup is amazing this year. Do not miss it.

EMBL Events@events.embl.org · 2mo ago

You only have until 11 Sep to submit your abstract for #EMBOomics! ➡️ s.embl.org/omx26-01-bl Join us to discuss the latest developments in the field with leaders in genomics, dynamic proteomics, quantitative imaging, and synthetic biology.

Finally, many thanks to the EMBL communication team for their beautiful piece www.embl.org/news/science...

A new genetic tool helps researchers uncover the logic of gene regulation | EMBL

Researchers use synthetic biology approaches to test hundreds of DNA sequences for their effect on regulating gene expression

embl.org

And into our companion computational method paper for details on FootprintCharter doi.org/10.1093/bioi...

FootprintCharter: unsupervised detection and quantification of footprints in single molecule footprinting data

AbstractSummary. Single molecule footprinting profiles the heterogeneity of TF occupancy at cis-regulatory elements across cell populations at unprecedente

doi.org

Dive into the revised paper for a deeper validation of our F1 and SOX2 dTAG perturbations, as well as a brand-new combinatorial TF motif deletion mCHIRA experiment.

How many TFs to you need to open chromatin at enhancers? Very excited to see this one out! Check out the augmented version with combinatorial motif mutant libraries in Figure 5! Very proud of @guidobarzaghi.bsky.social @valentinabaderna.bsky.social @embl.org

Guido Barzaghi@guidobarzaghi.bsky.social · 2mo ago

📄 That's a wrap 📄 we're excited to share that the latest from @arnaudkr.bsky.social 's lab and Judith Zaugg's lab is at last online at doi.org/10.1038/s415.... Many thanks to my co-first @valentinabaderna.bsky.social and to @embl.org for the wonderful research environment.

Check out our new review about SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada Two-A Containing) coactivator complexes in EMBO. doi.org/10.1038/s443.... We dissect the functions of SAGA and ATAC, which are crucial for understanding regulation by these complexes as targets in precision oncology.

Read this article, get excited, and come to the Epigenome Editing symposium! Marianne Rots, Charlie Gersbach, and Angelo Lombardo (all featured in the piece) will be there in person!! Registration only 50€, talks from abstracts, plus Paris 😜 @natureportfolio.nature.com www.nature.com/articles/d41...

Epigenetic editing makes its mark

Researchers are rewriting the chemical tags on DNA and chromatin to tune gene expression.

nature.com

Maxim Greenberg@maxvcg.bsky.social · 8mo ago

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Latest from @arnaudkr.bsky.social on TF cooperation at enhancers, liked the combination of single-molecule footprinting at ectopic vs endogenous loci in mESCs. Curious if the cumulative activation frequency model holds for other less proliferative/plastic cell types? www.nature.com/articles/s41...

Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency - Nature Genetics

This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor bindi...

nature.com

'Gene regulation, one molecule at a time' is coming back in July 17! Book your calendars and stay tuned!

EMBL Events@events.embl.org · 3mo ago

Get your calendars, because the new 2027 EMBL Annual Poster has arrived: s.embl.org/2027-poster Whether you'd like to enhance your skills in a practical course or engage with the latest research at one of our conferences, we've got you covered. See you at EMBL in 2027! 🙌 #LifeSciences #EMBL

One of my favorite meetings. Many slots for abstract selected talks! Friendly to junior scientist - apply!

Mike Dorrity@mwdorr.bsky.social · 3mo ago

We’re accepting abstracts for QBMM, come join an excellent set of speakers, due early Sept

I am starting my lab at the University of Geneva next January! Incredibly excited to soon be joining the MOCEL department as an Asst. Professor. The lab will use evolutionary cell biology to study chromosomes, centromeres & speciation 🧬🔬🌱 Intrigued, want to join or collaborate? 🔗 helsenlab.org

Helsen lab | chromosome and centromere evolution

The Helsen lab at the University of Geneva explores how centromeres and chromosomes evolve, diversify, and function across eukaryotes. Discover our latest publications, research team, and open positio...

helsenlab.org

In memory of Pierre Chambon (1931–2026): a visionary pioneer of modern molecular biology by Hinrich Gronemeyer in @embojournal.org link.springer.com/article/10.1...

In memory of Pierre Chambon (1931–2026): a visionary pioneer of modern molecular biology - The EMBO Journal

The EMBO Journal -

link.springer.com