Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis | Cell Host & Microbe @cellpress.bsky.social www.sciencedirect.com/science/arti...

Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis

Various forms of solid tumors harbor intracellular bacteria, but the physiological consequences of these microorganisms are poorly understood. We show…

sciencedirect.com

Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 | Cell Host & Microbe @cellpress.bsky.social Gets us closer to mechanisms underpinning long COVID and potentially other post viral syndromes. www.cell.com/cell-host-mi...

Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

SARS-CoV-2 infection can lead to long-lasting neurological sequelae, but underlying mechanisms are unclear. Rong et al. report that SARS-CoV-2 spike protein persists in the skull-meninges-brain axis, inducing inflammation, neurodegeneration-related changes, and increasing the brain’s vulnerability to further injury.

cell.com

Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social . Very exciting technology 🔬 #science #research #omics www.nature.com/articles/s41...

Method of the Year 2024: spatial proteomics - Nature Methods

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

nature.com

What do others think of this? I’m sceptical of any universal #microbiome signature. In this case they focus on genomes which “were detectable in more than 75% of the samples”. This seems very high to me but they found hundreds of genomes which met this threshold?

Host Microbe interactions@hostmicrobelit.bsky.social · 2y ago

A core microbiome signature as an indicator of health | Cell Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases www.cell.com/cell/fulltex...

A core microbiome signature as an indicator of health | Cell Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases www.cell.com/cell/fulltex...

Machine learning for microbiologists | Nature Reviews Microbiology "we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists". #microbology #machinelearning www.nature.com/articles/s41...

Machine learning for microbiologists - Nature Reviews Microbiology

In this Review, Segata, Waldron and colleagues discuss important key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools essential to apply machine l...

nature.com

The September issue of The Lancet Microbe is now online: www.thelancet.com/journals/lan... The journal is #OpenAccess, so you are free to explore all of the content. But these hashtags offer a flavour: #malaria #CandidaAuris #AMR #tuberculosis #TB #microbiome #MERS #Chagas #syphilis #OA

The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions | FEBS Journal. Comprehensive Review, summarizes evidence & highlights potential mechanisms. #Immunology #microbiome #openaccess febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub-optimal in vulnerable populations. Her...

febs.onlinelibrary.wiley.com

De novo discovery of conserved gene clusters in microbial genomes with Spacedust www.biorxiv.org/content/10.1... GitHub: github.com/soedinglab/s...

The march of the mRNA vaccines goes on. Clostridiodes difficile (C diff) next... #IDSky #MicroSky #MedSky 🧪 www.science.org/doi/10.1126/...

A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection

Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeti...

science.org

microshades: An R Package for Improving Color Accessibility and Organization of Microbiome Data #Microbiome #Rstats #metagenomics journals.asm.org/doi/10.1128/...

Shotgun metagenomics reveals interkingdom association between intestinal bacteria and fungi involving competition for nutrients | Microbiome Compares ITS vs Metagen + demonstrates how to enrich for fungi using centrifugation. microbiomejournal.biomedcentral.com/articles/10....

Shotgun metagenomics reveals interkingdom association between intestinal bacteria and fungi involvin...

Background The accuracy of internal-transcribed-spacer (ITS) and shotgun metagenomics has not been robustly evaluated, and the effect of diet on the composition and function of the bacterial and funga...

microbiomejournal.biomedcentral.com

Microbiome diversity protects against pathogens by nutrient blocking | Science I don't think this will be surprising to anyone in the field but nice to see it demonstrated in using a combination of in vitro and in vivo gnotobiotic experiments. #microbiome #science www.science.org/doi/10.1126/...

Microbiome diversity protects against pathogens by nutrient blocking

Diverse communities of commensal gut bacteria collectively limit pathogen colonization by blocking nutrient access.

science.org

Spatial host–microbiome sequencing reveals niches in the mouse gut | Nature Biotechnology SHM-seq - an all-sequencing-based approach that captures tissue histology, polyadenylated RNAs and bacterial 16S sequences directly from a tissue www.nature.com/articles/s41...

Spatial host–microbiome sequencing reveals niches in the mouse gut - Nature Biotechnology

Spatial host–microbiome sequencing simultaneously profiles microbes and host transcriptomes from mouse colons.

nature.com

Machine learning for microbiologists | Nature Reviews Microbiology "we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists". www.nature.com/articles/s41...

Machine learning for microbiologists - Nature Reviews Microbiology

In this Review, Segata, Waldron and colleagues discuss important key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools essential to apply machine l...

nature.com

Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra | Nature Microbiology Resource based upon analysis of 2,229 HMP genomes. Identified candidates in-siliso and validated in-vitro. www.nature.com/articles/s41...

Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity sp...

An analysis of over 2,000 genomes from Human Microbiome Project metagenomic data led to the identification of several extended- and narrow-spectrum antibiotics against clinical multidrug-resistant pat...

nature.com

The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans | Nature Medicine Very impressive dataset from 1651 households in China looking at bacteria and fungi in sputum. www.nature.com/articles/s41...

The airway microbiome mediates the interaction between environmental exposure and respiratory health...

Examining the interplay of environmental exposure with the airway microbiome provides insights for possible intervention in lung health.

nature.com

The Neuroscience School of Advanced Studies on "Microbiota🦠 & the Brain 🧠" will take place once again next May in wonderful Venice. Limited places, they always fill fast.. All levels welcome from PhD student to Full Professor www.neurosas.org/advanced-cou...

High-resolution strain-level microbiome composition analysis from short reads | Microbiome "we present a new strain-level composition analysis tool named StrainScan” github.com/liaoherui/St... microbiomejournal.biomedcentral.com/articles/10....

High-resolution strain-level microbiome composition analysis from short reads - Microbiome

Background Bacterial strains under the same species can exhibit different biological properties, making strain-level composition analysis an important step in understanding the dynamics of microbial c...

microbiomejournal.biomedcentral.com

Probiotic-guided CAR-T cells for solid tumor targeting | Science Immunotherapy is generally less effective for solid tumours (e.g. colon cancer). This reports on using an engineered E. coli to help with this process. #microbiology #cancer www.science.org/doi/10.1126/...

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes | Science Translational Medicine Large human shotgun metagenomcis study (n=440) from the Huttenhower lab. www.science.org/doi/10.1126/...

Antibiotic perturbations to the gut microbiome | Nature Reviews Microbiology "We present an overview of the currently complex picture of treatment-induced changes to the microbial community" www.nature.com/articles/s41...

Antibiotic perturbations to the gut microbiome - Nature Reviews Microbiology

In this Review, Fishbein, Mahmud and Dantas discuss factors that influence restructuring of the gut microbiome on antibiotic exposure, and they explore promising therapeutic avenues aimed at minimizin...

nature.com

Refugee from Xitter. Originally set up this account to force myself to stay up to date on the literature but became quite a fun hobby tbh 🤷‍♂️ I’ll start cross posting a bunch of stuff and see what the BlueSky community is like