Is healthy ageing possible on a normal diet? Our new eLIFE paper describes metabolic re-engineering of yeast to avoid senescence The A2A mutant we created is super-fit late in life even on a rich high glucose diet… these cells stay healthy until they die! elifesciences.org/articles/111...

Latest paper: link.springer.com/article/10.1...

Dietary restriction is evolutionary conserved on the phenotypic and mechanistic level - EMBO Reports

The anti-ageing response to Dietary Restriction (DR) is thought to be mechanistically ancient, reasoning from its phenotypic conservation. However, DR is implemented differently across species and evi...

link.springer.com

Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!

Replication-stress-induced chromatin loops protect fork stability - Nature

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

nature.com

New preprint: Cells surviving #osimertinib frequently enter a defective S phase with DNA replication and segregation errors Preventing S phase avoids emergence of #drug resistance Great work from Kieron May Collaboration with Matt Martin @astra-zeneca.bsky.social www.biorxiv.org/content/10.6...

Can anyone tell me why BlueSky (running in Firefox) crops images to be square when I am composing my post? The images display properly when I actually post them, but it makes it really hard to see what my post will look like...

I am still kinda new on BlueSky. Interested in #IBD, #Tcells, #TCR ? I would kindly appreciate Reposts! :-) insight.jci.org/articles/vie...

Interested in submitting for #BSRA 2026, our 75th annual meeting? Link here - bsra.org.uk/events/75th-...

75th Annual Scientific Meeting of the BSRA (2026): The Biology of Ageing - BSRA

BRITAIN’S LEADING AGEING RESEARCH CONFERENCE In 2026, the BSRA is pleased to host its 75th Annual Scientific Meeting on the Biology of Ageing at the University of Oxford between 9th and 11th September...

bsra.org.uk

A strong hint from human genetics that changes in DNA methylation may be causal for normal aging. This is the direction that aging (and cancer) research needs to go! www.nature.com/articles/s41...

A progeria syndrome links DNA hypermethylation to age-related pathology - Nature Genetics

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.

nature.com

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

Latest paper. We studied ATF4 in ageing in the fly. We find in contrast to previous suggestions that ATF4 suppression rather than activation extends lifespan. The study was largely conducted in an MSc project by Miriam Götz who showed an exceptional drive for science. www.pnas.org/doi/10.1073/...

The UK is one of only five of the richest 21 countries to see HLE decline. @ONS reports that healthy life expectancy is falling. BSRA advocates for increased funding in ageing research so we can all live healthier for longer. Dataset in the comments 👇 www.bbc.co.uk/news/article...

UK healthy life expectancy falls by two years in past decade

Poor housing, obesity and the effects of deprivation have been suggested as underlying cause.

bbc.co.uk

Travel Grants for #BSRA2026!!! Don't forget there is a seperate travel grant call *just* for BSRA 2026, our 75th annual meeting. This year in Oxford, it's promising to be a great meeting. bsra.org.uk/grants/ Like and share, or tag someone who should apply below👇

Grants - BSRA

Grants We are pleased to announce an additional grant call for 2026, for Travel Grants to attend our 75th ASM in Oxford from 9-11 September. CALL NOW OPEN. Closing date 1st May 2026. More details here...

bsra.org.uk

Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...

FEBS Press

DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...

doi.org

Need to profile DNA replication genome-wide? TrAEL-seq reveals replication patterns and fork progression in unsynchronised, unlabelled and unsorted cells Our revised protocol: • Provides far better data from mammalian cells • Includes 6-way multiplexing academic.oup.com/nar/article/...

Exciting new project in our lab @babrahaminst.bsky.social! We are working with @alesdantas.bsky.social at @newcastleuni.bsky.social to understand how extrachromosomal circular DNA mediates drug resistance in fungal pathogens Funded by @wellcometrust.bsky.social #ecDNA #eccDNA #Candida #Zymoseptoria

Post-doc job alert! Only a week left to apply for this post doc role, joining our team at the Babraham Institute @babrahaminst.bsky.social to explore ageing metabolism and epigenetics. babrahaminstitute.livevacancies.co.uk#/job/details...

Post-doc job alert! We have an exciting opportunity for a post doc to join our team at the Babraham Institute, exploring ageing metabolism and epigenetics. babrahaminstitute.livevacancies.co.uk#/job/details...

Our new Preprint describes an improved TrAEL-seq protocol: • Provides far better data from mammalian cells • Includes multiplexing for higher throughput TrAEL-seq reveals replication patterns and fork progression in unsynchronised, unlabelled and unsorted cells www.biorxiv.org/content/10.1...

If you're at the AGE meeting don't miss the BSRA Korenchevsky Award talk from Hanane Hadj-Moussa! Hanane's work shows that we can acheive excellent healthy ageing through metabolic rewiring, even on an unrestricted diet Profile: whova.com/embedded/spe... Preprint: www.biorxiv.org/content/10.1...

Is healthy ageing possible on a normal diet? Our latest Preprint describes metabolic re-engineering of yeast to avoid senescence The A2A mutant we created is super-fit late in life even on a rich high glucose diet www.biorxiv.org/content/10.1...

Congratulations to our PhD student Amy Wolstenholme for winning the Poster Prize at the EMBL Drug Resistance meeting #EESDrugResistance this week Amy's poster showed that circular DNAs providing copper resistance can be stably transmitted for hundreds of generations in yeast