Epigenetics Update - Replication-stress-induced chromatin loops protect fork stability u.epigenome.us/tbH5bRGB Vincent Gaggioli/Kaustav Sengupta and nitikataneja.bsky.social (erasmusmc.bsky.social) in nature.com #Epigenetics #Chromatin #ChromatinLooping --- epigenometech.com

Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!

Replication-stress-induced chromatin loops protect fork stability - Nature

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

nature.com

Our lab is featured in the latest Erasmus MC Annual Report. Thanks to my team, our collaborators and funding agencies for their continued support & making this possible! 🙏 Read here👇: digitaalpubliceren.com/erasmusmc/21...

Today we are very pleased to share our latest article available now online @narjournal.bsky.social about the role of Slx4 scaffold and Fun30 (SMARCAD1 homolog) in DNA damage response regulation and replication fork protection against Top1-DNA crosslinks. academic.oup.com/nar/article/...

Thank you to @doksanilab.bsky.social, @nitikataneja.bsky.social, and everyone who joined us for such a great discussion today! We’re excited to invite you to our next webinar on March 3rd with @centromellone.bsky.social and Michele Pagano.

Please note that the zoom link for tomorrow's webinar with @nitikataneja.bsky.social and @doksanilab.bsky.social has been updated: uzh.zoom.us/j/6466274666...

Another great science appointment is coming up with @nitikataneja.bsky.social and @doksanilab.bsky.social! Join us live on Tuesday, February 3rd at 5pm (Rome) / 11am (NYC). Zoom link: uniroma1.zoom.us/j/95149984403 Register here to stay in the loop: docs.google.com/forms/d/e/1F...

Delighted & grateful to receive @erc.europa.eu support once again! This ERC-PoC will translate fundamental insights into therapy-induced chromatin reorganization toward proof-of-concept in ovarian cancer patient samples. Special thanks to @oncodeinstitute.bsky.social for continued support! 🙌

Delighted to be part of this work from the Lopes lab identifying nucleoplasmic Lamin A/C as a key regulator of replication fork plasticity, acting via de novo heterochromatin and ADP-ribosylation to control RECQ1-mediated fork restart. Now in Nature Comm. 🎉Special efforts: @joannapaulson.bsky.social

Lopes_Lab@lopeslab.bsky.social · 8mo ago

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social www.science.org/doi/10.1126/...

Halloween borrel at the department 🎃 : our PhDs & Postdocs showed next-level creativity by revealing the hidden monstrous sides of their PIs! 👻😂 Absolutely hilarious & scary indeed😜… though I’m starting to wonder if that’s really how they see me 👀😅

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress

Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone mH2A1.2 ubiquitination in p...

cell.com

First preLights post from Jenny Singh (@jennysingh.bsky.social‬) She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure & restraining RECQ1 activity. #preprint #preLight ⬇️ prelights.biologists.com/highlights/n...

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels - preLights

Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure and restraining RECQ1 activity.

prelights.biologists.com

⏰🚨FINAL DEADLINE APPROACHING #BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬! Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF

#SouthKorea

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

Abortion bans kill women

gamera obscura@ohrobin.bsky.social · last yr.

My dear friend’s niece, who in October developed sepsis when a Georgia hospital refused her a D&C after a miscarriage, will be taken off life support tomorrow. I don’t know the names of the countless others who have suffered and will suffered because of anti-abortion laws. But her name was Haley.

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

Join us in Lisbon this July to learn how cells "Balance Genome Fidelity & Plasticity". deadline for talks extended and a # of fellowships are available to offset trainee registration. www.fusion-conferences.com/conference/1...

Fusion Conferences@fusionconf.bsky.social · last yr.

📢SHORT TALK DEADLINE EXTENDED!📢 If you didn't get the chance to submit for a short talk for #BGFP25 🧬, don't worry! We have extended our deadline to 01 April ! To submit, please visit our website to register bit.ly/4g4XN0U OR email: alice@fusion-conferences.com

Happy to have contributed(along with PhD students @joannapaulson.bsky.social & Collin Bakker) to such great work from @lopeslab.bsky.social and team! www.biorxiv.org/content/10.1...

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Mild replication interference is a consolidated strategy for cancer chemotherapy. Tolerance to mild replication stress (RS) relies on active fork slowing, mediated by transient fork reversal and RECQ1...

biorxiv.org

Lopes_Lab@lopeslab.bsky.social · 2y ago

Project lead in our lab by @vcherdy.bsky.social with key collaborative contributions, mainly from @nitikataneja.bsky.social. Another important step forward, investigating how nuclear architectural components orchestrate the replication stress response throughout the nucleus!

Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social www.science.org/doi/10.1126/...

Alex Carver@alexcarver.bsky.social · 2y ago

NEW in @science.org, so happy to contribute to our understanding of the molecular machine, Fidgetin-like 1 (FIGNL1), and elucidating the mechanism of why cells cannot survive when it is lost! #ScienceResearch science.org/doi/10.1126/... (1/7)

What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk

behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩‍🔬 🧵. www.nature.com/articles/s41...

Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by Diana, Marta and Paula! www.cell.com/cell/fulltex...

What an exciting day for the lab at the Dutch Chromatin Meeting! Congrats to Ashutosh (a.k.a Vincent 😉)for winning the poster prize on 3D reorganization of stressed forks & Joanna for her fantastic talk on phase separation during replication stress. Proud of you guys! 🤩

Two back-to-back papers in Nature comms from mylab explore the link between destabilization of the actin cytoskeleton and aberrant base excision repair - passing through nuclear actin and the actin-dependent nucleosome remodeler INO80C.

The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics

The single-molecule accessibility landscape of newly replicated mammalian chromatin

By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...

cell.com

First post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...

Profound synthetic lethality between SMARCAL1 and FANCM

Feng et al. uncover a critical genetic interaction between the DNA translocases SMARCAL1 and FANCM. Their combined loss leads to catastrophic genome instability, particularly at simple-repeat sequence...

cell.com

Fantastic study… Congratulations Francesca n team! 👏

Francesca Mattiroli@fmattiroli.bsky.social · 2y ago

The peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉 And don’t miss the chromatin haiku! www.cell.com/molecular-ce...