A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. www.biorxiv.org/content/10.6...

ER cholesteryl ester phase separation underlies switch-like cholesterol sensing

Cellular lipid homeostasis requires mechanisms that detect subtle changes in lipid abundance and trigger rapid, coordinated responses. The INSIG/SCAP/SREBP2 pathway provides a central feedback system ...

biorxiv.org

Bhaskar Naidu, Vera Lillo, Manneville, Miserey, @felixmendu.bsky.social et al. show that extracellular mechanical forces reciprocally regulate #Golgi function. The study reveals a feedback pathway by which Golgi export supports cell spreading and mechanoadaptation. rupress.org/jcb/article/...

In their Perspective article, Marintia Nava-García @marintianava.bsky.social, Michelle Baird @michelleabaird.bsky.social and colleagues discuss the emerging roles of lipids in nuclear function and homeostasis. journals.biologists.com/jcs/article/...

Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...

ESCRT-III assembles around mis-segregated DNA to protect genome stability - Nature Structural & Molecular Biology

The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.

nature.com

Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...

🔬 Join us at CRBM for a seminar by Christian Schlieker (Yale University) on biomolecular condensates, nuclear organization, and their links to neurological disease. 📅 June 23 | 🕚 11:00 AM | 📍 Salle Marcel Dorée #CRBM #CellBiology #Neuroscience #BiomolecularCondensates

Please re-post! Time is almost up to register for the 2026 FASEB Lipid Droplet Meeting. Abstracts are due May 31, 2026. See link below, and join us for an amazing SRC lipid meeting July 26-30! #LipidSRC events.faseb.org/event/Lipid-...

Today we are very pleased to share our latest article available now online @narjournal.bsky.social about the role of Slx4 scaffold and Fun30 (SMARCAD1 homolog) in DNA damage response regulation and replication fork protection against Top1-DNA crosslinks. academic.oup.com/nar/article/...

Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...

FEBS Press

DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...

doi.org

Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...

FEBS Press

DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...

doi.org

ATM controls Golgi morphology ATM controls Golgi morphology ATM controls Golgi morphology ATM controls Golgi morphology

@MorieLAB@morielab.bsky.social · 4mo ago

When DNA damage responders are not only that: @MorieLAB.bsky.social shows that, without ATM, one master kinase responding to DNA damage, the Golgi is markedly deployed. ATM phosphorylates Golgi substrates to limit Golgi extension, which matters for Golgi cargo maturation: doi.org/10.64898/202...

When DNA damage responders are not only that: @MorieLAB.bsky.social shows that, without ATM, one master kinase responding to DNA damage, the Golgi is markedly deployed. ATM phosphorylates Golgi substrates to limit Golgi extension, which matters for Golgi cargo maturation: doi.org/10.64898/202...

When DNA damage responders are not only that: @MorieLAB.bsky.social shows that, without ATM, one master kinase responding to DNA damage, the Golgi is markedly deployed. ATM phosphorylates Golgi substrates to limit Golgi extension, which matters for Golgi cargo maturation: doi.org/10.64898/202...

Very important work, we should care much more about resistance to antibiotics…

Mickaël Blaise@mickael-blaise.bsky.social · 5mo ago

Glad to share our latest study on poorly investigated human pathogen Nocardia cyriacigeorgica. lnkd.in/gewKAYBj

Visit our fully accessible journal archive, providing perpetual access to 34k articles from over a century of pioneering research in developmental biology, cell biology, comparative physiology and biomechanics, including work from 60+ Nobel Prize-winners bit.ly/3PfIjib

The application deadline for the 20th FEBS/EMBO Spetses meeting is extended to the 15th March! Please sign up at the link below, or encourage your PhDs and postdocs to come along for what is certain to be a wonderful week!

Alison Forrester@aforrester.bsky.social · 6mo ago

CALLING PHDs AND POSTDOCS! Apply for the 20th FEBS/EMBO summer school on Membranes lipids & proteins in organelle biogenesis! Spend a glorious week with leaders in the field on the beautiful island of Spetses in Greece this May. Registration: spetses2026.sites.uu.nl @embo.org @febspress.bsky.social

The greatest opportunity. Do not self-censor! Try!!

The Company of Biologists@biologists.bsky.social · 5mo ago

Getting involved as an organiser of one of our Workshops is easy. We focus on the logistics, so you can focus solely on the science. Watch this video to hear from some of our previous organisers. The call for proposals for 2028 programme runs until 29 May. www.youtube.com/watch?v=eShr...

Happy to share our new paper in @febsj.bsky.social! With @ondrej-kuda.bsky.social & @fedorovalab.bsky.social we show how #LipidDroplets reshape the lipidome of PUFA-exposed cells, but can also shift function within the same cell, revealing a context-dependent role in #ferroptosis. shorturl.at/TyRl1

Only one month left to apply!! Remember: CRBM = Good & Happy Science

FocalPlane @focalplane.bsky.social · 6mo ago

The Centre for Research in Cellular Biology of Montpellier @crbm-montpellier.bsky.social is recruiting Junior/Senior Group Leaders. Check out the details on our cell biology jobs board: focalplane.biologists.com/cell-biology...

It’s finally out! Together with @embopress.org and @reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).

Read this @emboreports.org paper here=> link.springer.com/article/10.1...

Oded Rechavi@odedrechavi.bsky.social · 5mo ago

It’s finally out! Together with @embopress.org and @reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).

Thanks so much for highlighting our study! The tool is versatile and ready to uncover so much new knowledge 😀

The FEBS Journal@febsj.bsky.social · 6mo ago

🌄 We'd like to suggest a great start into a new week with this highlighted study #Highlights2025 📕 A CRISPR-Cas9-based system for the dose-dependent study of DNA double-strand break sensing and repair 🧬 Discover the article, here ➡️ buff.ly/kDp40pZ #CRISPR #DNAbreak #DNArepair

Do you have a vision for a Workshop but don’t have the time to arrange the logistics or raise the funding? Submit your idea to us in our annual call for topics. We'll provide all necessary support for successful applications. Find out more at biologists.com/workshops/pr...

The Centre for Research in Cellular Biology of Montpellier @crbm-montpellier.bsky.social is recruiting Junior/Senior Group Leaders. Check out the details on our cell biology jobs board: focalplane.biologists.com/cell-biology...

The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders - FocalPlane

The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders to shape its research in the coming decade

focalplane.biologists.com

Arnav Saha, Tushar Sherkhane and Nagaraj Balasubramania uncover a mechanosensitive pathway linking ECM stiffness to Golgi organisation and function in breast cancer cells. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Please REPOST (“likes” don’t help in diffusion!) and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

CRBM-Montpellier@crbm-montpellier.bsky.social · 6mo ago

We are hiring!

Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

CRBM-Montpellier@crbm-montpellier.bsky.social · 6mo ago

We are hiring!

Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

CRBM-Montpellier@crbm-montpellier.bsky.social · 6mo ago

We are hiring!

New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization. www.biorxiv.org/content/10.6...