A pathogenic CDC42 M45L variant strengthens binding to pyrin B30.2, triggering inflammasome activation and autoinflammatory disease www.science.org/doi/10.1126/... @sethlucianmasters.bsky.social @hudsonresearch.bsky.social @shouyafeng.bsky.social

8/9 I started this in 2017 with Jan Rehwinkel at University of Oxford @imm.ox.ac.uk and continued with Paul Hertzog at @hudsonresearch.bsky.social @ciiid-hudson.bsky.social. Massive thanks to all collaborators across countries and over many years! 📜 Read the paper: www.nature.com/articles/s41...

Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection - Nature Immunology

MDA5 detects double-stranded RNA during viral infections. This work shows that MDA5 binds aberrant host RNA induced during viral infection. Rescue of aberrant cytoplasmic RNA during infection abrogate...

nature.com

Loved chatting to @drshanerrr.bsky.social on @3rrrfm.bsky.social Einstein-A-Go-Go. Took along my 7yo: “Mum, I can’t believe you were on the radio!” Talking #innateimmunity, #virus #infection and #inflammation research at @hudsonresearch.bsky.social Particularly our recent #MDA5 study. #scicomm

Today is Australia’s first-ever Medical Research Giving Day! 🔬 Every $1 donated to medical research returns $4, turning discoveries into breakthroughs. ❤️ Gifts to @hudsonresearch.bsky.social today will be matched up to $10,000. Support medical research: bit.ly/4qVWpE8 #MedicalResearchGivingDay

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Join Australia's first ever Medical Research Giving Day. On 9 September 2026, more than 30 medical research institutes will unite for one day to fund the breakthroughs that improve and save lives.

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Understanding prolonged brain sparing fully could unlock new opportunities to improve the diagnosis and management of FGR. #FetalGrowthRestriction #FGR #PregnancyResearch #Placenta #FetalPhysiology #Neonatology #Obstetrics @hudsonresearch.bsky.social @monashuniversity.bsky.social

Noxopharm’s partnership with @hudsonresearch.bsky.social Research is at the core of the company’s groundbreaking technology. Here’s CEO Dr Olivier Laczka talking about the relationship with Hudson Institute and how it’s going from strength to strength: youtu.be/dukYQiZtQGw

Noxopharm CEO - Hudson Institute of Medical Research partnership

YouTube video by Noxopharm

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A @hudsonresearch.bsky.social team has received a $1 million Medical Research Future Fund grant for a project involving Noxopharm’s Sofra™ platform, which addresses birth injuries that lead to debilitating pelvic floor disorders (PFDs) in women. More here: www.noxopharm.com/pdf/14f66e17...

Professor Michael Gantier @gantierlab.bsky.social from @hudsonresearch.bsky.social, Noxopharm’s strategic partner, will be a keynote speaker at a free international webinar on 17 June. More details including specific timings and a registration link can be found here: sciforum.net/event/Pharma...

⭐️ 2025 Annual Report ⭐️ 447 researchers, with a shared mission: improving human health. Inside you'll discover the breakthroughs, collaborations and innovations shaping the future of medical research, and bringing hope to people who need it most. Dive in: https://bit.ly/3d9Gsmc

Congratulations to @jackkemery.bsky.social. His work, recently published in the Journal of Extracellular vesicles, identified that bacterial EVs traffic nucleomodulins directly to the host cell nucleus. doi.org/10.1002/jev2... @isev.org @hudsonresearch.bsky.social @ciiid-hudson.bsky.social

Outer Membrane Vesicles Mediate the Secretion and Nuclear Trafficking of a Bacterial Nucleomodulin

(A) We propose that Helicobacter pylori secretes a nucleomodulin, Tumour Necrosis Factor-α-inducing protein (Tipα), predominantly via extracellular vesicles (EVs), also known as outer membrane vesicl...

doi.org

Yesterday we stood with fellow researchers from across Victoria to deliver a clear message to the Government: increase investment in medical research to keep Vic at the forefront of scientific innovation & breakthroughs, & to ensure our community continues to benefit from life-changing discoveries.

As research into the gut microbiome grows, scientists are exploring its potential role in early brain development Prof Sam Forster has received a prestigious award through Wellcome Leap’s Foundations of a Resilient Microbiome (FORM) program to optimise this research Read more https://bit.ly/3NbrAw3

It's Endometriosis Awareness Month! Learn more about our endometriosis research: https://bit.ly/4doO0V3

Professor Caroline Gargett joined a panel to discuss her #Endometriosis research and the gender pain gap on Well. by Mamamia 🔊 Tune into this episode via Spotify: https://bit.ly/3OTUVvt Apple: https://apple.co/4ulVtu7 Youtube: https://bit.ly/4uo4iDQ

Noxopharm and @hudsonresearch.bsky.social announce a breakthrough scientific paper regarding the Sofra™ platform in top-ranking journal Nature Immunology. Read the full announcement here: www.noxopharm.com/pdf/e17f82ba...

A/Prof Miranda Davies-Tuck & Dr Keeth Mayakaduwage examined whether The Safer Baby Bundle reduced stillbirth & perinatal mortality & whether its benefits were experienced equitably across communities. Their findings are very encouraging. 🔗 bit.ly/4ko6QgK

#MedicalResearch saves & changes lives. 🔬 Hudson Institute of Medical Research is proud to stand behind this campaign calling on the Australian government to release the full legislated quota from the Medical Research Future Fund each year. ➡️ bit.ly/49ByUcH #MedicalResearchMatters

Medical Research Matters

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🔥 #Inflammation is your body’s response to infection or injury, but in overdrive it can result in your immune system mistakenly attacking healthy tissue. It's the cause of 50% of deaths worldwide & underpins hundreds of chronic diseases & conditions. 🌏

Do you have a #MenstrualCycle? 🩸 We're conducting a study to help us understand the physical, social & emotional factors that may influence a person’s decision to participate in studies about #MenstrualFluid. Find out more about the Cycles for Science Study: https://bit.ly/4aQ7S2c

Another great presentation from @hudsonresearch.bsky.social Centre for Innate Immunity and Infectious Diseases (CiiiD) PhD student, Anita Chaulagain (@aneeta0110) about type I interferon signalling during Shigella flexneri! #YoungVIIN2025 #VIINYIS

Dr Julia Chitty showing us how pirfenidone can be repurposed to treat viral exacerbations of COPD based on a novel precision-cut lung slice model. Exciting work! #YoungVIIN2025 #VIINYIS @monashuniversity.bsky.social @hudsonresearch.bsky.social

Rachelia Raissa Wibawa from @hudsonresearch.bsky.social gave an excellent talk on her research which has identified novel genetic mutations in Legionella pneumophila that impact host transcriptional responses #YoungVIIN2025 #VIINYIS

Belated post of my macaron centrepiece from last week’s @ciiid-hudson.bsky.social Christmas party – “the cells of CiiiD”. A lot of work to produce this undetermined number of macarons (I lost count) 🙃 Big thanks to @biorender.bsky.social who I used to make the templates! @hudsonresearch.bsky.social

Grateful to work with some amazing people at the @ciiid-hudson.bsky.social @hudsonresearch.bsky.social Including these special super smart ladies @jackiheraudfarlow.bsky.social and @sciencesophie.bsky.social #sciencetribe 🧪👯‍♀️

Science buddies are the best. Definite highlight of moving to @hudsonresearch.bsky.social has been learning from these two.

Natalia Sampaio@drnatsampaio.bsky.social · 10mo ago

Grateful to work with some amazing people at the @ciiid-hudson.bsky.social @hudsonresearch.bsky.social Including these special super smart ladies @jackiheraudfarlow.bsky.social and @sciencesophie.bsky.social #sciencetribe 🧪👯‍♀️

@hudsonresearch.bsky.social gingerbread getting me through my last day of work before the holidays 🎄🧪🎄🧪🎄🧪

New paper from Dr Zahrah Azman et al. shows preterm growth-restricted lambs with asphyxia have impaired vascular contractility and heightened cardiac adrenergic responses, insights that matter for neonatal cardiovascular outcomes. Read & share 👇 pubmed.ncbi.nlm.nih.gov/41432623/ #FGR #CardioSci

In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia - PubMed

Fetal growth restriction (FGR) arises from chronic hypoxia and increases the risk of cardiovascular dysfunction following perinatal asphyxia, although underlying mechanisms remain unclear. We investigated whether cardiovascular responses to asphyxia are impaired in preterm FGR lambs and whether this …

pubmed.ncbi.nlm.nih.gov

New study from our group: Umbilical cord milking as a technique to harvest cord blood derived cells for regenerative applications www.nature.com/articles/s41... @drabdulrazak.bsky.social @courtney-mcdonald.bsky.social @hudsonresearch.bsky.social @pediatricresearch.bsky.social

Congrats to this year's National Health & Medical Research Council (NHMRC) Idea Grant recipients! 👏🥳 Seven of our researchers have been awarded over $13.4 million in NHMRC Ideas Grants to work on projects ranging from newborn health to viral & bacterial infections. Read more 👉 bit.ly/496uNVH

🚨 Preprint Alert 🚨 We discovered a new regulator of RIG-I-like receptors #MDA5 #RIG-I, which are critical innate immune sensors of #RNA that detect #viral infection. Check out our #biorxiv #preprint: www.biorxiv.org/content/10.1... tl;dr 🙃 thread below