I’m super excited to be opening a lab at WEHI. We’ll be focussing on how double-stranded RNA is regulated in cells, how failures in these pathways drive disease and new therapies to manipulate inflammatory responses to RNA. #newPI #RNAsky

WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · 8mo ago

Say hello to our incoming lab heads! 👋 Excited to announce Dr Danika Hill, Dr Jacki Heraud-Farlow and Dr Sylvie Callegari will soon be establishing new labs at WEHI. More info: www.wehi.edu.au/news/excepti... bsky.app/profile/sylv... bsky.app/profile/jack... bsky.app/profile/prec...

Check out our new preprint on dirCLIP, the first method capable of interrogating RNA-protein interactions in their native transcript context by combining UV crosslinking and immunoprecipitation (CLIP) with amplification-free direct nanopore long-read sequencing! 1/4 www.biorxiv.org/content/10.6...

Science buddies are the best. Definite highlight of moving to @hudsonresearch.bsky.social has been learning from these two.

Natalia Sampaio@drnatsampaio.bsky.social · 10mo ago

Grateful to work with some amazing people at the @ciiid-hudson.bsky.social @hudsonresearch.bsky.social Including these special super smart ladies @jackiheraudfarlow.bsky.social and @sciencesophie.bsky.social #sciencetribe 🧪👯‍♀️

Thank you @drshanerrr.bsky.social for speaking on behalf of all of us. It’s such wasted effort for 92% of applicants. Wouldn’t it be great if they took the spare 600 mil gathering dust at MRFF and funded an extra 10% of ideas grants?

Dr Shane Huntington OAM@drshanerrr.bsky.social · 11mo ago

The success rate for NHMRC Ideas Grants announced yesterday was just over 8%. That means 11 of every 12 people who applied got rejected. This is a culture changing level of rejection and frankly a point of national shame. This is a crisis for research. I will not rest until we see this resolved.

🚨 Preprint Alert 🚨 We discovered a new regulator of RIG-I-like receptors #MDA5 #RIG-I, which are critical innate immune sensors of #RNA that detect #viral infection. Check out our #biorxiv #preprint: www.biorxiv.org/content/10.1... tl;dr 🙃 thread below

ARC says Discovery Projects outcomes will be tomorrow (Tuesday). Linkage Projects (2025, round 1) on Wed. Over past ~year, it's often been at about 11am (Canberra). My bot will pick up the change to RMS & post immediately. ARC should email outcomes to lead CIs, but might take an 1hr or so for DPs

Happy to share our review on the Interplay between RNA-protein interactions and RNA structures. The open access article can be accessed here: doi.org/10.1002/2211...

FEBS Press

Methodological advances in mapping transcriptome-wide RNA-protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA...

doi.org

Last day of #ARNASydney2025 and this cartoon from @xkcd.com is just particularly appropriate, so I had to re-share! #RNAsky

Super fun presenting some of our #MDA5 #RNA sensor work to an RNA-centric audience! The different point of view from my usual infection and immunity background led to some great questions and discussions. More ideas forming!!! #ARNASydney2025 #virus 🧪🧫🦠

Selene FeRNAndez@selfdz.bsky.social · last yr.

We had a set of amazing talks in the #RNA in immunity session at #ARNASydney2025. Presentations by Stacey Horner, @drnatsampaio.bsky.social, Elizabeth Chan and Kitty McCaffrey. From viral infections to bacterial toxins, a really great session. #RNASky

Application for 2025/2026 RNA Salons is now open. Please apply by 31st August to receive support your local or regional RNA activities. @rnasociety.bsky.social #Lexogen www.rnasociety.org/salons

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1... Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

Registration for A-RNA 2025 is now open!!! Join us in September for 3 days of #RNA Science. We have an excellent lineup of invited speakers (www.a-rnameeting.org.au/invited-spea...) & networking events Register: www.a-rnameeting.org.au/registration Early bird rate ends July 30th, 2025 #RNASky

I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting

Nature Reviews Genetics@natrevgenet.nature.com · 2y ago

New online! Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

RNA xkcd.com/3056

Today is Rare Disease Day Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au Five rare diseases and support groups:

Cool stuff @cp-cell.bsky.social by @raflynn5.bsky.social & friends on presence & functions of glycoRNA microdomains on the plasma membrane! 👇👇👇

Ryan Flynn@raflynn5.bsky.social · 2y ago

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

Wow, looking forward to reading this one. Do the spliced TEs trigger nucleic acid sensors like PKR or MDA5? #RNASky #ImmunoSky

Oded Rechavi@odedrechavi.bsky.social · 2y ago

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

Attention all Melbourne #RNA researchers. The next RNAVic minisymposium is now open for FREE registration. To be held at @hudsonresearch.bsky.social on March 27th with a great lineup of local speakers from research and industry. This is an RNA salon event supported by @rnasociety.bsky.social.

Michael Gantier@gantierlab.bsky.social · 2y ago

For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at www.rnavic.com

#RNAsky #RNAbiology

PLOS Biology@plosbiology.org · 2y ago

How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN

#IL_NAT25 Yuval Dor on RNA editing in diabetes. Thought inflamation caused by virus, but no virus found. Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation? Data indicates yes, by ADAR KO mouse model. Phenotype similar to progression of diabetes in humans

The world of RNA modifications expands again! ADP-ribosylation discovered in the arms race of host-pathogen interactions. #RNASky #Immunosky

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 2y ago

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...

Waiting for flight back to Oz and reflecting on the awesome @keystonesymposia.bsky.social last week on #RNA mediated regulation of #immunity. Here are a few highlights with links to the published or preprinted papers which you should definitely check out if you haven't yet ... #RNAsky #Immunosky

Really enjoyed reading in #MolecularCell "RNA sensing induced by chromosome missegregation augments anti-tumor immunity" They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly. www.sciencedirect.com/science/arti...

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention #RNAbiology #RNAlocalization www.nature.com/articles/s41...

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention - Nature Communications

Here the authors study how interactions with nuclear speckles help localize mRNA in cells. They find that modifications of the proteins in these structures affects their cohesion and can modulate mRNA...

nature.com

Proud to share our paper on the impact of transcription inhibition on mRNA export in cancer. A big thanks to collaborators, especially to Ewa Michalak, Vi Wickramasinghe, Jeff Chao and Mark Dawson @mafdawson.bsky.social. @fmiscience.bsky.social

Mark Dawson@mafdawson.bsky.social · 2y ago

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...

At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)

Magda Kopczyńska@mgkopczynska.bsky.social · 2y ago

Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end. In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵 academic.oup.com/nar/advance-...

Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284 🤔 useful to further reduce translational load during #ISR? #RNAbiology

RNA sensing induced by chromosome missegregation augments anti-tumor immunity www.cell.com/molecular-ce...

RNA sensing induced by chromosome missegregation augments anti-tumor immunity

Sasaki et al. demonstrate that chromosome missegregation induced by SAC inhibition results in cytoplasmic dsRNA accumulation, primarily generated from non-exonic regions in the MNs. Activation of MAVS-mediated dsRNA sensing cooperates with dsDNA sensing to promote anti-tumor immunity.

cell.com

Efficient circular RNA synthesis for potent rolling circle translation. Congratulations to Yifei and the team in Venki's lab at @mrclmb.bsky.social! www.nature.com/articles/s41... #RNA #RNABiology #RNAsky #Translation #mRNA

Efficient circular RNA synthesis for potent rolling circle translation - Nature Biomedical Engineering

Trans-splicing-based methods that are independent of bacterial sequences and that allow the incorporation of RNA modifications enable the reliable synthesis of circular RNAs and enhance the efficiency...

nature.com

Very important study to consider in light of the many miRNA cancer network and association studies out there!

Alejandro Montenegro@aemonten.bsky.social · 2y ago

"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles" www.biorxiv.org/content/10.1...