Huocong Huang
@huoconghuang.bsky.social
Huang Lab, UT Southwestern Medical Center. Studying fibroblast in cancer, wound and aging.
Happy to share our latest work in collaboration with Sihan Wu and James Chen labs. We found ecDNA is not only a vehicle, but can drive oncogene super expressors that induce a unique stromal niche by AREG secretion. This rapidly leads to myCAF expansion and T cell exclusion.
bioRxivpreprint@biorxivpreprint.bsky.social · 9mo agoecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment https://www.biorxiv.org/content/10.1101/2025.11.15.688565v1
Our paper online now, CAF molecular phenotypes are more conserved than we thought across organs. Plus we now know more details about apCAFs. Please check it out 👉 Cancer Cell www.cell.com/cancer-cell/...
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches
Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...
cell.com
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
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Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
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Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...
Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression
Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...
aacrjournals.org
🚨 2024 is coming to a close but #research on #fibroblast #functions in #cancer it’s far from done ✅. If you want to know more, have a read at our latest #review now in press @trendscancer. 👇🏼👇🏼 Fantastic job by Priscilla and Marta 🌟👏🏻. And happy 2025 to all 🫶 www.sciencedirect.com/science/arti...
Functional heterogeneity of fibroblasts in primary tumors and metastases
Cancer-associated fibroblasts (CAFs) are abundant components of the tumor microenvironment (TME) of most solid malignancies and have emerged as key re…
sciencedirect.com
Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.
science.org
Multiple NCI-PSRC investigators co-authored this perspective in Cancer Research last month: #PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here? aacrjournals.org/cancerres/ar... @kenolivelab.bsky.social @marasherman.bsky.social @debvendramini.bsky.social @tme-caf-ecm.bsky.social
aacrjournals.org
#PancreaticCancer research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss? go.bsky.app/FDafAW
Thank you @gabriellebrewer.bsky.social for highlighting our work in Nature Reviews Cancer, led by grad student @justeng95.bsky.social. Check out the original paper in Cell here: www.cell.com/cell/fulltex... Here's a summary thread from "the other site": x.com/PeterLyLab/s...
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance
A genetic screen uncovers the Fanconi anemia pathway as a driver of chromothripsis by shattering under-replicated micronuclear chromosomes during mitosis. This process involves chromosome-scale cleava...
cell.com
Gabrielle Brewer@gabriellebrewer.bsky.social · 2y ago2) A #Researchhighlight (by yours truly) of a study from the @peterlylab.bsky.social that identified the FA pathway as a driver of chromothripsis. 👉 bit.ly/3OizHUk
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches https://www.biorxiv.org/content/10.1101/2024.11.15.623232v1
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches https://www.biorxiv.org/content/10.1101/2024.11.15.623232v1
Recent studies have identified a unique subtype of cancer-associated fibroblasts (CAFs) termed antig
biorxiv.org
Thanks Deb! Happy to share our work on pan-cancer analysis of apCAF at an unprecedented resolution. Through this study we have a much better idea about this CAF subtype!
Debolina Ganguly@debolina-ganguly.bsky.social · 2y agoIt’s great to see this pre-print from the @huoconghuang.bsky.social! Must read for people interested in apCafs!