👀 Une étude parue dans Science Advances impliquant des scientifiques de l'Institut de génomique fonctionnelle de Lyon @igflyon.bsky.social

CNRS Biologie@cnrsbiologie.bsky.social · 3w ago

#ResultatScientifique🔎| Une nouvelle étude montre comment les signaux Wnt et BMP orchestrent pas à pas la diversité musculaire au cours du développement 🪰 ▶️ buff.ly/gB2KPJD ✍️ @enriquezlab.bsky.social 📕 Science Advances 🤝 @cnrs.fr @cnrs-rhoneauvergne.bsky.social @ensdelyon.bsky.social

🔬 Meet Michalis Averof, ZooCELL PI at IGFL @michalis-averof.bsky.social What sparked his interest in EvoDevo? What keeps him curious after all these years? And what does he hope to discover next? 🧵 Read on to get to know Michalis through his own words. #ZooCELL#EvoDevo#genomics#IGFL#MSCA

How do dozens of distinct muscles emerge from the same pool of precursor cells? Our new Science Advances paper uncovers the developmental logic that coordinates myoblast identities to build diverse muscles. 📄 www.science.org/doi/10.1126/... #DevelopmentalBiology #Drosophila #Muscle

Spatiotemporal control of myoblast identity drives muscle diversity in the Drosophila leg

This study reveals how muscle diversity arises in flies, enabling the complex movements that drive animal behavior.

science.org

🧠 IGFL External seminar | @dulaclab.bsky.social (Harvard/HHMI) deciphers the neural circuits underlying instinctive social behaviors (parenting, mating, aggression) and how the brain drives adaptive behavioral changes during sickness. What a treat! 🧠

Only few days left to apply! This event is relevant both for wet lab biologists who want to learn more about spatial OMICs and get initiated to data analysis and for bioinformaticians who want to learn about the latests developments in spatial OMICs.

Yad Ghavi-Helm@yghavi.bsky.social · 3mo ago

📢Join us for the Spatial-Cell-ID #spatialOMICs Summer School, September 13-18th 2026, at the Centre Paul-Langevin in Aussois, in the French Alps! You can find the full scientific program, our speakers, and the application form on our website: spatial-cell-id.github.io/scid2026/ Please share!

Very proud to host the great one and only Catherine Dulac @dulaclab.bsky.social at IGFL, @igflyon.bsky.social @ensdelyon.bsky.social, on June 1st 2026! I am all excited like a fan can be when meeting one of her idols 😱. Don't hesitate to join if you're in Lyon that day 🧠

These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9

In animals with large genomes, finding cis-regulatory elements can be very challenging. Enhancers can be located tens/hundreds of kb away from their target promoters. We face this challenge in Parhyale, with >3 Gbp genome. We just published a preprint describing how we are tackling this problem. /1

L’IGFL recrute un•e Professeur•e des Universités en biologie moléculaire (CNU 64), UCBL Lyon 1. Enseignement L2-M2 (Biochimie et Biologie Moléculaire) + projet en biologie moléculaire des eucaryotes au sein de l’IGFL. Détails: shorturl.at/K5Dno #Recrutement #BiologieMoleculaire

Un poste de Professeur des Universités va être ouvert lors de la campagne d’emploi 2026 à l’université Claude Bernard Lyon1 - Profil Recherche : Biologie Moléculaire des Eucaryotes. Profil Enseignement: Biologie Moléculaire. Profil ci-joint. Merci de diffuser dans vos réseaux.

Such a pleasant moment listening to the original science from @audeber.bsky.social today at @igflyon.bsky.social @ensdelyon.bsky.social. Out of the box ideas, Outstanding tools, Out of my comfort zone… Totally great!

Bacteria-dependent ecdysone lengthens hungry stomachs This Research Highlight showcases work from Longwei Bai (@longweibai.bsky.social), François Leulier (@francoisleulier.bsky.social) and colleagues at @igflyon.bsky.social journals.biologists.com/dev/article/...

IGFL external seminar Birds keep losing their penises, repeatedly. Not by chance. Anamaria Necsulea (LBBE Lyon) shows how changes in gene regulation and non-coding DNA drive convergent developmental loss of the male phallus across avian evolution.

Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social journals.biologists.com/dev/article/... Review process via @reviewcommons.org and @dev-journal.bsky.social 1/3

Bacteria-dependent ecdysone lengthens hungry stomachs

Intestinal growth restriction in starving Drosophila larvae can be selectively rescued by Lactiplantibacillus plantarum (Lp) bacteria in the gut, but how microbiota promote growth is not well understo...

journals.biologists.com

François Leulier@francoisleulier.bsky.social · 9mo ago

Revised refereed preprint: www.biorxiv.org/content/10.1... Revision work lead by @longweibai.bsky.social Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.

#ResultatScientifique🔎| Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ? ✍️ @francoisleulier.bsky.social 🤝 @cnrs-rhoneauvergne.bsky.social @igflyon.bsky.social @ensdelyon.bsky.social 📕 @dev-journal.bsky.social ▶️ buff.ly/R1VJvDm

Le microbiote active les stéroïdes intestinaux pour contrecarrer la malnutrition

Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ? Une étude publiée dans Developm

buff.ly

Plus que quelques jours pour candidater. Rejoignez-nous!

IGFL@igflyon.bsky.social · 8mo ago

Mobilité interne CNRS : l’IGFL recrute un·e assistant·e ingé pour renforcer ses travaux sur modèles aquatiques et biologie cellulaire. Environnement technologique solide, missions variées recherche/élevages. Candidatures jusqu’au 15/01/2026. emploi.cnrs.fr/Offres/MOBIN...

Amazing to have @alainchedotal.bsky.social with us today @igflyon.bsky.social in front of a full room of people from all over the @ensdelyon.bsky.social campus! Very happy start of 2026 🤯

Very very excited to have Elly Tanaka from @imbavienna.bsky.social for our external seminar series @igflyon.bsky.social! Thanks Eglantine Heude for hosting 🤯

Mobilité interne CNRS : l’IGFL recrute un·e assistant·e ingé pour renforcer ses travaux sur modèles aquatiques et biologie cellulaire. Environnement technologique solide, missions variées recherche/élevages. Candidatures jusqu’au 15/01/2026. emploi.cnrs.fr/Offres/MOBIN...

Very proud to have defended my HDR (« Habilitation à diriger les recherches ») at @ensdelyon.bsky.social. Many thanks to the jury for their constructive feedbacks @clairewyart.bsky.social @francoisleulier.bsky.social @FlorenceRuggiero @PaulineSpéder @stemdevevo.bsky.social @OlivierRaineteau!

It's done! I am now a PhD for real! I defended my PhD thesis last week and what an incredible day it was. I am very grateful to all the members of @igflyon.bsky.social who made these last 4 years and 8 months so memorable. I will cherish all these memories 😊

What are these? You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social see doi.org/10.1101/2024... 🧵

When the clock’s feedback loop breaks, chromatin keeps ticking 🕒 Work from @clocklab-igfl.bsky.social reveals how H3.3-linked PBAF/cBAF shifts sustain BMAL1 activity and reshape circadian chromatine, linking epigenetics to metabolic and ageing control. 🔗 nature.com/articles/s41467-025-64045-2

PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback - Nature Communications

Rhythms in chromatin state guide circadian gene expression. Here, the authors show that histone H3.3 coordinates BMAL1 activity along with cBAF/PBAF remodelers. Circadian disruption promotes remodeler...

nature.com

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...

Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity

Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...

biorxiv.org

📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH

Our new study, just accepted in the Journal of the Endocrine Society 👉 doi.org/10.1210/jend... We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.

Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale apply here: www.averof-lab.org/pages/tracman 1/3

Michalis Averof@michalis-averof.bsky.social · last yr.

We've just been awarded a grant to study the cellular basis of regeneration – to track the progenitors of sensory organs in the context of leg regeneration, in our favourite crustacean tinyurl.com/parhyale, based on live imaging and cell tracking. The project involves some cool collaborations... 1/3

Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux! www.ens-lyon.fr/indexation/a...

Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏

CNRS Biologie@cnrsbiologie.bsky.social · 11mo ago

#ResultatScientifique🔎| Des scientifiques combinent biologie et modélisation mathématique pour révéler comment l’organe olfactif se forme chez l’embryon de poisson zèbre 🐟 ✍️ Julie Batut 📕 @cp-iscience.bsky.social | buff.ly/iO4GqPA

So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!