Excited to share my latest work in the @oliveiramann.bsky.social lab, where we examined STING dependent and independent nucleotide signalling pathways in human cells with a library of 78 nucleotides by RNA-seq and imaging analysis

bioRxiv Immunology@biorxiv-immuno.bsky.social · 9mo ago

Profiling Nucleotide Signalling Pathways and STING Agonist Activity with a Nucleotide Library https://www.biorxiv.org/content/10.1101/2025.11.11.687896v1

Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2

Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2

Oligoadenylate synthetases (OASs) are a family of double-stranded RNA (dsRNA)-activated nucleotidyltransferases involved in pathogen sensing and innate immune response. In this issue of Molecular Cell, Merold et al. define a mechanism of OAS2 activation by dsRNA-length discrimination and its deficiency associated with autoimmune disorder.

dlvr.it

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

Molecular Cell @cp-molcell.bsky.social · last yr.

Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504 @oliveiramann.bsky.social 🎥ProLehre

In search of molecular switches in the immune system

A decades-long search culminated in 2013 with the discovery of cGAS – a molecular switch that plays a key role in the human immune system. Carina Baer de Oliveira Mann was a doctoral student with the ...

go.tum.de

Happy to share the first preprint from my lab by @indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity! Check out Indra’s thread for a summary:

Indra_Beķere@indrabekere.bsky.social · 2y ago

I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...

Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1

I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...