Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes

Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym

doi.org

Excited to see this work published online at @cp-cell.bsky.social today! www.cell.com/cell/fulltex...

A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

CFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase to enable the selective and directional retrieval of polyubiquitinated proteins from cilia, a process essential for m...

cell.com

Sven Lange@sven-m-lange.bsky.social · last yr.

How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n

The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat... My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.

PhD position in Gene Regulation

Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!

uu.nl

🎉 Thrilled to share our new paper in @narjournal.bsky.social! We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social 🔗 doi.org/10.1093/nar/...

Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions

Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und

doi.org

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology

Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

nature.com

Much appreciate the spotlight on our (‪@adelmanlab.bsky.social‬) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology

Molecular Cell @cp-molcell.bsky.social · last yr.

Integrator complex collapse: A mechanistic route to integrated stress response and disease

Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall? Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬

FragileNucleosome@fnucleosome.bsky.social · last yr.

FN is taking a summer vacation 🏖️, but we'll be back in September with more exciting talks on chromatin and transcription! If you've got a new story you'd like to share with the FN audience this fall, fill out the form here: docs.google.com/forms/d/e/1F...

Exciting new work from Apoorva Baluapuri of the Adelman lab! @baluapuri.bsky.social @adelmanlab.bsky.social www.sciencedirect.com/science/arti...

Integrator loss leads to dsRNA formation that triggers the integrated stress response

Integrator (INT) is a metazoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for termination, preventing immatur…

sciencedirect.com

Apoorva Baluapuri@baluapuri.bsky.social · last yr.

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Thrilled to see my work with @adelmanlab.bsky.social on INT/dsRNA highlighted by @willgarland.bsky.social and @heick.bsky.social ! Thanks for beautifully capturing how nuclear RNA guardians prevent cellular chaos. The ripple effects of transcriptional dysregulation are indeed profound! #RNABiology

William Garland@willgarland.bsky.social · last yr.

We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social. Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.

Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series! In case you haven't joined any of the previous 2025 sessions, here is registration link: us06web.zoom.us/webinar/regi...

Why are there intronic reads in your bulk RNA-seq data? You're not alone—it's common, and the reasons are more layered than you think. Let’s break it down. 🧵

Sometimes when I am having a bad day I remember that after my TED talk in 2016 this woman mobbed me afterwards and threw herself on me with the hugest hug saying "Oh my god you were incredible and inspirational I want to BE you" It was Cher

Was great presenting at @fnucleosome.bsky.social - amazing feedback and participation from the audience. Thanks once again to the organizers:) here’s the link press release for the story for those who missed it : hms.harvard.edu/news/what-ha...

FragileNucleosome@fnucleosome.bsky.social · last yr.

~In 1 hr!!!!

Read all about Apoorva Baluapuri’s new work on Integrator (INT) in HMS News! @baluapuri.bsky.social @adelmanlab.bsky.social tinyurl.com/y2fx22c2

What Happens When a Gene Quality-Control Mechanism Fails?

Study solves riddle of how mutations in Integrator complex relate to neurodegeneration, cancer

tinyurl.com

You can read our full Review @science.org here 👉👉https://www.science.org/doi/10.1126/science.adp2959

Stem cells as role models for reprogramming and repair

Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decade...

science.org

Helmholtz Munich@helmholtzmunich.bsky.social · last yr.

🎤 Stem Cells & the Future of Regenerative Medicine: #Interview with Prof. Torres-Padilla & Prof. Götz Read how breakthroughs in #stemcell biology are driving new therapies. 👉 t1p.de/9ojjg @metorrespadilla.bsky.social @epihmgu.bsky.social #StemCellResearch #HelmholtzMunich #Epigenetics

Looking forward to share my postdoc work done with @adelmanlab.bsky.social, and to revisit @fnucleosome.bsky.social as a presenter once more after 3 years !!! Super excited….

FragileNucleosome@fnucleosome.bsky.social · last yr.

⚡Next Wednesday! In our next #FragileNucleosome seminar session, we are delighted to host, @baluapuri.bsky.social and @juliecocquet.bsky.social! If you've registered to one of our previous 2025 sessions, you can use the same link to join our next session. If not: us06web.zoom.us/webinar/regi...

Thanks @mpi-ie.bsky.social for the having me over last week and for the great conversations I had at your nice institute cradled in the beautiful Schwarzwald !!

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · last yr.

This Friday, we have a guest from Harvard Med School: Apoorva @baluapuri.bsky.social is a @dfg.de Walter Benjamin Fellowship holder who studies mRNA synthesis in the @adelmanlab.bsky.social. We are looking forward to a talk to learn more about gene regulation mechanisms by the Integrator complex.

Another McGill Assistant Professor job at the Lady Davis Institute (where I am)! This is for an immunology (host-virus interactions) position! Come by my colleague! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724)

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

mcgill.wd3.myworkdayjobs.com

🧵 Want to automate bioinformatics tasks? Start by mastering one of the most powerful tools: the for loop in bash. I know I posted about GNU parallel :) but even "for loops" have a lot to learn Let’s go.

Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle

Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle

Control over protein phosphorylation timing is crucial for faithful cell cycle progression. Takacs et al. revisit existing qualitative and quantitative models for cyclin-dependent kinase (Cdk) control of the cell cycle. They provide evidence of a third mechanism in which the substrates themselves contribute to controlling their phosphorylation timing.

dlvr.it

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach. More details: www.nature.com/naturecareer... Apply by 04 MAY #PostdocJobs #ScienceJobs

Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response

Integrator loss leads to dsRNA formation that triggers the integrated stress response

Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.

dlvr.it

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Excited to be at @keystonesymposia.bsky.social for first time ! Looking forward to plenty of science&fun at #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25 #RNA #GeneReg #RNAsky #GeneRegulation

hi, are you, or do you know a musician in san diego? i need to borrow guitar amp and PA in couple weeks. please RT and help connect me to gear!🎸 @benoitbruneau.bsky.social @wbderry.bsky.social @thelovelylab.bsky.social @chrmosimann.bsky.social @zineeditor.bsky.social @nstop.com @lostsoundtapes.com

. Haiku for 2025 Every day it's just What in the actual fuck Please please make it stop #haiku

Polls close shortly in Germany. What a good election outcome for Europe would look like: - stable two-part government formed swiftly - AfD underperforming (sub-20%) - clear 2/3 majority (420+ seats) for debt-brake reform - parties pivoting fast from campaign to wider realities

Incredibly timely and informative review article @cp-cell.bsky.social by @jstingele.bsky.social and team on #RNA Damage www.cell.com/cell/fulltex...

Cellular responses to RNA damage

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

cell.com