Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/45fpXCZ

Diverse bacterial pattern recognition receptors sense the core phage proteome - Nature

Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural and replicative proteins of bacteriophages.

go.nature.com

Caroline Langley's primary thesis chapter from her time as a grad student in @memerman.bsky.social's and my lab is now published. She shows that HIV-1 Vif’s ability to maintain A3G antagonism depends on structural robustness, which permits adaptation, and epistasis, which imposes constraints.

@JohnGrossSF@johngrosssf.bsky.social · 3w ago

Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins | Science Advances www.science.org/doi/10.1126/... Congratulations on this beautiful work!

In print today @science.org Laser phase plate improves structure determination of small proteins by cryo-EM | Science www.science.org/doi/10.1126/...

Laser phase plate improves structure determination of small proteins by cryo-EM

Phase plates can, in principle, overcome the poor image contrast in cryo–electron microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous de...

science.org

🧬 Meet the NUCLEATE Cluster of Excellence 🧬 Backed by the @dfg.de Excellence Strategy, we are a research alliance redefining the future of nucleic acid science by uniting 3 of Germany’s top universities in Munich and Würzburg: @lmu.de @tum.de @uni-wuerzburg.de #NUCLEATECluster #DFG

Now online! STING signaling modulation by COPII cargo recognition

STING signaling modulation by COPII cargo recognition

Lyu et al. identify the STING-ER-exit motif and the mechanism of its recognition by the COPII vesicle cargo-binding protein SEC24C. This study reveals how STING achieves controlled rather than constitutive ER exit and how COPII cargo recognition of STING can be modulated to control STING signaling.

dlvr.it

How can we study the function of nucleotide-based #SecondMessengers? @oliveiramann.bsky.social presented her group's exciting findings in this field at #Biochemistry2026. She e.g. presented the #cryoEM structure of OAS2, which has key #antiviral functions. linkinghub.elsevier.com/retrieve/pii...

"Nucleotidyltransferases and nucleotide-based second messengers" Carina Baer de Oliveira Mann (@oliveiramann.bsky.social) gave an insightful talk on this topic at #Biochemistry2026. febs.onlinelibrary.wiley.com/doi/full/10.... #Biochemistry #SecondMessenger #CyclicNucleotide CC: @gdch.de

We are very excited to be hosting #Biochemistry2026 in Würzburg in the coming 3 days. We have a great program of speakers waiting for you! If you are on the way to Würzburg, share your excitement with #Biochemistry2026! (1/3) www.gdch.de/biochemistry... #ChemSky #ChemBio #Biochemistry @gdch.de

You are interested in immunology and how nucleic acid structures contribute to their function and how this impacts disease development - Rayk Behrendt and myself have open PhD positions for a joint PhD program between Bonn and Osaka.

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

The vault associates with membranes in situ https://www.biorxiv.org/content/10.64898/2025.12.12.693869v1

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

science.org

Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne! @brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social

We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12 @istaresearch.bsky.social this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts #cryoEM Deadline for abstracts Oct 15 Final deadline Oct 31 cryoem-symposium.pages.ist.ac.at

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching! Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv! www.biorxiv.org/content/10.1...

Myeloperoxidase transforms chromatin into neutrophil extracellular traps @nature.com @intein.bsky.social @mpiib-berlin.mpg.de www.nature.com/articles/s41...

What is cell death? Honored to participate in this article where the question was posed to a dozen experts. Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion. rdcu.be/eG1Nm

Towards a molecular and structural definition of cell death

Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

rdcu.be

📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection

Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

biorxiv.org

Laser flash melting cryo-EM samples to overcome preferred orientation pubmed.ncbi.nlm.nih.gov/40877464/ #cryoEM

Feeling recharged after our lab retreat in Obergurgl 🌞⛰️ Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social. Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration! www.cell.com/cell/fulltex...

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

cell.com

Proud to present a cover inspired by the structural and functional analysis of OAS2 by @oliveiramann.bsky.social, @indrabekere.bsky.social, and Veronika Merold, live at @cp-molcell.bsky.social. Big news on RNA sensing and antiviral defenses! #sciart ⌬ #research ⌬ #chemistry ⌬ #immunology

Carina de Oliveira Mann@oliveiramann.bsky.social · 2y ago

Happy to share the first preprint from my lab by @indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity! Check out Indra’s thread for a summary:

Excited to share our latest update on @cp-cell.bsky.social! We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses. www.cell.com/cell/abstrac...

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

cell.com

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

Molecular Cell @cp-molcell.bsky.social · last yr.

Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:

Wow, so cool!🌟 Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy 🥂🥳🤩 www.lmu.de/en/newsroom/... @v-hornung.bsky.social

NUCLEATE Cluster of Excellence: beacon of nucleic acid research

The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.

lmu.de

Together with the Roers Lab from @uniheidelberg.bsky.social and @bms-us.bsky.social we propose that controlled low level systemic activation of #cGAS by endogenous nucleic acids is a safe and effective way to boost #cancer #immunotherapy. aacrjournals.org/cancerres/ar...

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504 @oliveiramann.bsky.social 🎥ProLehre

In search of molecular switches in the immune system

A decades-long search culminated in 2013 with the discovery of cGAS – a molecular switch that plays a key role in the human immune system. Carina Baer de Oliveira Mann was a doctoral student with the ...

go.tum.de