🔬Revelan factores potencialmente claves en la resistencia al daño de las células cancerosas  👩‍🔬Un equipo del @cbm-csic-uam.bsky.social ha identificado factores que amenazan la supervivencia celular cuando falla la vigilancia, como ocurre en los tumores ➡️ http://tiny.cc/tves001

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it! Now online here 👇🏼 academic.oup.com/nar/article/...

S-phase checkpoint protects from aberrant replication fork processing and degradation

Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

academic.oup.com

Our latest study from my postdoctoral work has just been published in Science Advances! Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social 🔗 www.science.org/doi/10.1126/...

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Upon ATR inhibition, APOBEC3B targets unprotected single-stranded DNA at replication forks, leading to fork breakage.

science.org

Glad to see our PACT preprint published in @naturecomms.bsky.social! "Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA" Another step forward in understanding innate immunity. @buissonlab.bsky.social 🔗 www.nature.com/articles/s41...