New work out on mpox diagnostics in DRC, including from our study site in Uvira. Demonstrates that qPCR data need to be interrogated and interpreted alongside clinical and other data given risks of false positives at high Cts.
Geneva Disease Dynamics group@gddynamics.bsky.social · 3w agoOur work on false-positive mpox results in high-transmission settings is out @thelancetinfdis.bsky.social. Of 2,724 suspected cases in DR Congo, ~35% of qPCR positives (Ct<40) were estimated to be environmentally derived. A Ct cutoff of <34 reduced this to ~5%, with only marginal sensitivity losses
