Vaccines hold tantalizing promise in the fight against dementia

A prominent Nature study and related research raise the possibility that vaccines may have a broader role in experimental therapeutics outside the realm of infectious diseases.

buff.ly

Vascular collapse leads to muscle wasting in cancer cachexia - Nature Cancer

Muscle atrophy in cachexia drives weight loss and represents a major complication for patients with cancer. The tumor-derived cytokine activin A is now shown to decrease endothelial cell viability in ...

nature.com

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer

Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

nature.com

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer

Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

nature.com

Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy - Nature Communications

Senescent cells accumulate in tissues with aging and disease but are difficult to detect due to distinct cell-type-specific senescence phenotypes. Here, the authors present the SenePy algorithm to ide...

nature.com

Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics

Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

nature.com

Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome

Single-cell CRISPR screens link genetic perturbations to transcriptional states, but high-throughput methods connecting these induced changes to their…

sciencedirect.com

Best practices for differential accessibility analysis in single-cell epigenomics - Nature Communications

The authors conduct a comprehensive assessment of statistical methods for identifying differentially accessible (DA) regions in scATAC-seq data, using a compendium of scATAC-seq experiments paired wit...

nature.com

Identification of antigen-presenting cell–T cell interactions driving immune responses to food

The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

science.org

Synthetic organizer cells guide development via spatial and biochemical instructions

Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development.

cell.com

Conventional chemotherapy: millions of cures, unresolved therapeutic index - Nature Reviews Cancer

Conventional chemotherapy has successfully cured millions of patients with cancer, yet the mechanisms of action for this remain unclear. In this Perspective, Letai and de The assess the existing mecha...

nature.com

Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice

Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitoc...

science.org

Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses

The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...

science.org

Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs

Lewis and Xie et al. systematically quantified translation functions of >30,000 human 5′ UTRs, revealing regulatory sequence elements and RNA modifications that impact the initiation process. This approach can aid the design of therapeutic mRNA and facilitate the dissection of the molecular mechanisms of translation initiation.

cell.com

GenomeDelta: detecting recent transposable element invasions without repeat library - Genome Biology

We present GenomeDelta, a novel tool for identifying sample-specific sequences, such as recent transposable element (TE) invasions, without requiring a repeat library. GenomeDelta compares high-qualit...

genomebiology.biomedcentral.com

A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity

The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.

cell.com

Zoll stoppt geschmuggelte Dubai-Schokolade

Steuerstrafverfahren eingeleitet und Einfuhrabgaben von knapp 920 Euro nacherhoben

zoll.de

Cellular RNA interacts with MAVS to promote antiviral signaling

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

science.org

RNA sensing induced by chromosome missegregation augments anti-tumor immunity

Sasaki et al. demonstrate that chromosome missegregation induced by SAC inhibition results in cytoplasmic dsRNA accumulation, primarily generated from non-exonic regions in the MNs. Activation of MAVS-mediated dsRNA sensing cooperates with dsDNA sensing to promote anti-tumor immunity.

cell.com

Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation

Structural variants (SVs) drive gene expression in the human brain and are causative of many neurological conditions. However, most existing genetic studies have been based on short-read sequencing me...

biorxiv.org

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon

LINE-1 (L1) retrotransposition is widespread in many cancers, especially those with a high burden of chromosomal rearrangements. However, whether and to what degree L1 activity directly impacts genome...

biorxiv.org

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

nature.com

Nucleosome fibre topology guides transcription factor binding to enhancers - Nature

Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

nature.com

Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration

Intermittent fasting halts hair follicle regeneration by activating communication between adrenal glands and niche adipocytes, which in turn selectively induces apoptosis of hair follicle stem cells but not epidermal stem cells in the skin.

cell.com

Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans

Gene flow from Neanderthals has shaped genetic and phenotypic variation in modern humans. We generated a catalog of Neanderthal ancestry segments in more than 300 genomes spanning the past 50,000 year...

science.org