James McCulloch

@jamesimcc.bsky.social

Evolutionary genomics PhD student at the Wellcome Sanger Institute/University of Cambridge. National recorder for springtails. Evolutionary biology, entomology, taxonomy, natural history... https://www.sanger.ac.uk/person/mcculloch-james/

Pleased to say that the first half of my PhD project is now out in preprint format! Using cortical organoids to model the mechanical transitions involved in early neurogenesis, we find that nuclear mechanotransduction is a crucial regulator of the timing and outcome of neuronal differentiation:

Organoids reveal niche-specific mechanotransduction-guided human cortical patterning and cell fate acquisition

The highly dynamic mechanical environment of the developing cerebral cortex has the potential to encode information vital for neuronal differentiation. Changes in local biophysical properties have bee...

biorxiv.org

Exploring Copenhagen while at #SMBE2026 Visit The Little Mermaid & look a few m along the shoreline. You’ll see some impressive (and polycentric) Bolboschoenus (club-rush). Their polycentromeres are likely underpinned by satellites I called Garrett and Colleen More: www.biorxiv.org/content/10.6...

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James McCulloch@jamesimcc.bsky.social · last mo.

I’m excited to be at #SMBE2026! I’m keen to talk to people about chromosome evolution/centromeres in the polycentric sedges and rushes (see poster or www.biorxiv.org/content/10.6...) … … or about population genomics of soil arthropods!

When I sat down with @jamesimcc.bsky.social to learn about all things springtails, I never imagined I'd leave our conversation so inspired about the future of natural science research. I can't wait to see what the future has in store for James. I certainly look forward to following the journey! 😊

Wellcome Sanger Institute@sangerinstitute.bsky.social · 2mo ago

No clue what a springtail is? Never fret. We've interviewed the UK's national springtail biological recorder and PhD student @jamesimcc.bsky.social . Head to our blog to learn more ⤵️ https://sangerinstitute.blog/2026/03/26/studying-soils-unsung-heroes/ 📸 Tim Jonas #NameItToSaveIt

Close-up of a brown and yellow springtail with a round, speckled body and fine hair, standing on mossy ground.

Chromosomes are often classified as either monocentric (single centromere per chr) or holocentric (centromeric activity spread across each chr). In reality, there is a continuum in centromere organisation - and cyperids are a fascinating system to explore this in as James shows in this preprint! 🌱

James McCulloch@jamesimcc.bsky.social · 5mo ago

Why do the chromosomes of cyperids (sedges & rushes) split and fuse so regularly on evolutionary timescales? Is it because they have so many centromeres? Our new preprint, the first major paper of my PhD, addresses this question. 🧵⬇️ 1/12 www.biorxiv.org/content/10.6...

A sedge. It may look unassuming but its genome has several unusual features.

I'm doing an online talk on 16/09 about my MSc thesis, which was all about iNaturalist data for invertebrates in the UK, and the alarmingly high proportion of it which 'falls through the cracks' due to data quality concerns. Please join if interested! Link: www.eventbrite.co.uk/e/falling-th...

Falling through the Cracks: iNaturalist Invertebrate Records in the UK

Joss Carr discusses his MSc Research Project investigating the data quality of UK invertebrate records on iNaturalist.

eventbrite.co.uk

I'm so excited to share that this springtail, one that seems to have rapidly appeared in graveyards and gardens across the UK, now has a proper name: Entomobrya petri! I hope this will be the first of many new species descriptions, allowing us to track our rapidly changing springtail fauna. 🧵⬇️

Soil Organisms Journal@soilorganismsj.bsky.social · last yr.

📢✨ONLINE FIRST✨ New #collembola species found in the UK! James McCulloch @jamesimcc.bsky.social National Recorder of Sprintails, tells the world about Entomobrya petri! 💚 Please REPOST 📢🪱🌱 soil-organisms.org/index.php/SO...