I gave a workshop on AlphaFold & related programs @ the University of Utah. Part 1 covers protein structure prediction before/after AlphaFold & deep learning neural networks. Part 2 covers the math behind the scores. Part 3 covers PyMOL & the webservers. youtube.com/@rolanddunbr...

WEHI researchers have found glycogen can be directly regulated using ubiquitin, in landmark findings published in Nature. The study transforms understanding into glycogen metabolism & could lead to new treatments for diseases caused by abnormal sugar storage. www.wehi.edu.au/news/sweet-d... 🧵1/2

Brilliant findings, led by Dr Simon Cobbold, Marco Jochem and Prof David Komander (pictured L-R). The study is also a collaboration with The University of Melbourne, University of Cologne and Alfred Health. 🧵2/2

Check out our latest paper on the ubiquitination of glycogen in cells and tissues! Congratulations to Marco Jochem (@marcojochem.bsky.social) and Simon Cobbold for leading this study and to collaborators @craigagoodman1.bsky.social, @pgregorevic.bsky.social, Kai Hofmann and Thomas Hermanns.

Marco Jochem@marcojochem.bsky.social · 4mo ago

Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...

Thank you @foglizzomartina.bsky.social for the nomination, and thank you to everyone for your support. This recognition reflects the creativity and hard work of our entire team, past and present, as well as the many collaborators whose contributions make our discoveries possible.

Martina Foglizzo@foglizzomartina.bsky.social · 4mo ago

Big congratulations to Elton @zeqiraj.bsky.social for his Biochemical Society Sustained Excellence Award!! 🎉 Thanks to everyone who supported the nomination! @astburycentre.bsky.social @universityofleeds.bsky.social

Our new Essays in Biochemistry review frames the DNA double strand break repair as multifunctional molecular machinery, showing how flexible our repair systems safeguard genomes from damage and help shape better cancer therapies 🧪 https://doi.org/10.1042/EBC20253043

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4 Preprint: www.biorxiv.org/content/10.6... Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

Nature Structural & Molecular Biology, Published online: 05 December 2025; doi:10.1038/s41594-025-01717-zRiechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.

go.nature.com

We just published a commentary on Francesca Bufalieri’s new article in a Molecular Therapy that shows the power or tweaking the UPS to modulate Hedgehog signalling in cancer. With @zeqiraj.bsky.social and Kevin Shi. authors.elsevier.com/a/1mBKX5QliS...

I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

science.org

First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....

Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex! @wehi-research.bsky.social

Sylvie Callegari@sylviecallegari.bsky.social · last yr.

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

🔬Sibling rivalry alert! Our Krios 2 is finally catching up with Krios 1 with a shiny new Selectris energy filter! ⚡ Exciting times ahead! Huge thanks to @thermofishersci.bsky.social for the upgrade! 🙌 #cryoEM #cryoET

Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!

Elton Zeqiraj@zeqiraj.bsky.social · last yr.

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

Very happy to share the work from my PhD is out today in @naturesmb.bsky.social ! Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology

The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

nature.com

New pre-print from the lab @cbmr.science spearheaded by PhD student, Conchita Bringas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social; providing structure-based molecular insights & cellular actions of the recently identified potent #AMPK inhibitor, BAY-3827.

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

Inhibition of AMP-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases, including certain cancers. However, existing AMPK-inhibitors availab...

biorxiv.org

Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social

Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex

Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...

link.springer.com