Just because it's Monday, we love #microscopy & we love #mitochondria, the powerhouse of the #cell We videoed mito under the microscope to see their dynamics. Here they join forces! Ofc we <3 the other #organelles too (to prevent jealousy) From @cellcommlab.bsky.social 🧪🔬 @focalplane.bsky.social

Al Jawazneh, Liebold, Leyk, Bosurgi et al. show that engulfment of bile acid–loaded hepatic parenchymal cells results in the transfer of bile acids to phagocytic #macrophages, altering their inflammatory profile. rupress.org/jem/article/... @pjsaez.bsky.social #Inflammation #Cholangitis

1 week to start🔥 New @focalplane.bsky.social webinar series focused on #CellMigration, register & join us▶️, it will be fun! pls spread the word, in the next one, ECRs could apply to show their work ;) ▶️ to register: focalplane.biologists.com/2026/05/29/n... @dgz.bsky.social @the-node.bsky.social

We are excited to announce another new webinar series, this time on cell migration, hosted by @pjsaez.bsky.social & @valeriaventurini.bsky.social. In our 1st webinar, we’ll hear talks from @juanmagararc.bsky.social, @kyohalie.bsky.social & @djcohen.bsky.social. 🗓️11 June, 15:00 BST

New webinar series on cell migration - FocalPlane

New webinar series on cell migration - News

focalplane.biologists.com

🧵 The AI industry is obsessed with making models bigger. I just made one 95% smaller, and it got better in the process ✨ 👇🏽👇🏽👇🏽

🧵 Time for a new introduction, as a lot has changed in the last year! Hi! 👋 I'm Javier, ML Engineer and Biotechnologist, working at the intersection of efficient AI and biomedical research ⚛️🧬

#FluorescenceFriday Jost, Schweizer et al. @ Cuello lab found that a mutation linked to aortic aneurysmas led to distorted actin #cytoskeleton in VSMCs #mechanobiology New collab @cellcommlab.bsky.social by @jboixcampos.bsky.social🔥 Full www.sciencedirect.com/science/arti... #microscopy #cell 🧪🔬

Congrats to all authors, & collaborators @hfspo.bsky.social especially #NirGov Also thanks to those that allowed to promote our work, @dgz.bsky.social Here, a webinar I gave @tlmcambridge.bsky.social, in case someone is interested in the other aspects of the story. youtu.be/xorWG5Jh_8o?...

Pablo Sáez (University Medical Center Hamburg - Eppendorf) "Decision-making during cell migration"

YouTube video by Theory of Living Matter Group - Cambridge U

youtu.be

#FluorescenceFriday Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️? (movie of the actin #cytoskeleton) Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬

Congrats Javi @jboixcampos.bsky.social, you did a fantastic work, so it's very much deserved ! For the next one !

Our work is finally published in @science.org Advances! 🎉 My very first paper, and what a journey it's been 🙂‍↕️ Huge thanks to the whole team, and especially to @pjsaez.bsky.social for believing in me. It turned out way better than I could've ever dreamt ✨ 📄 science.org/doi/10.1126/sciadv.ads2734

Trade-off between branching and polarity controls decision-making during cell migration

Highly branched cells require fine-tuning of polarity and shape dynamics to ensure balance between exploration and migration.

science.org

Pablo J. Sáez@pjsaez.bsky.social · 7mo ago

We combined cell biology, #AI based image analysis & a mathematical model to show how migratory behaviour changes with branching For now macrophages & endothelial cells, but we have many more, stay tuned ;) Kudos to all authors for the effort, especially to a great Padawan @jboixcampos.bsky.social

We combined cell biology, #AI based image analysis & a mathematical model to show how migratory behaviour changes with branching For now macrophages & endothelial cells, but we have many more, stay tuned ;) Kudos to all authors for the effort, especially to a great Padawan @jboixcampos.bsky.social

#HappyNewYear ! Let's start 2026 with a @cellcommlab.bsky.social paper How many branches is OK during #CellMigration? It depends on the #cell: for ex. immune cells are just fine. In collab. w. #NirGov @hfspo.bsky.social Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬

Hot from the press ! Happy to see this out, and that @cellcommlab.bsky.social contributed with live-cell imaging Autoimmunoglobulin-triggered extracellular vesicles (movie) contribute to kidney disease Full www.cell.com/cell/fulltex... @focalplane.bsky.social @cp-cell.bsky.social #microscopy 🧪🔬

Do you want to do some frontier of knowledge research? There's still time to register for the next webinar of @hfspo.bsky.social By far one of the best agencies I've worked with for my beloved HFSP project, even if it's a bumpy road...no risk no glory... www.hfsp.org/hfsp-events/...

Learning mindset: every error teaches, every failed analysis provides insight, every solution deserves celebration! Growth through experimentation 🎯

Perfect Sunday in Valencia: laptop in sunshine, working on analysis approaches! Sometimes the best office is wherever inspiration strikes 🌊

Always explore existing tools before building from scratch! The open-source ecosystem is incredible. Standing on giants' shoulders = more time for research 🛠️

Fascinating connection: medieval astronomical charts and modern computational biology plots both try to reveal hidden patterns in complex systems. Timeless challenge! ⭐

Every computational biologist started with confused first attempts (and not only the first ones hahaha)! We all begin somewhere - keep learning and building 💪

Data viz philosophy: your plot should tell a clear story immediately, not require lengthy explanation. Good visualization communicates instantly! 📊

Taschen book insight: the best historical infographics combined accuracy with beauty. Modern data viz can learn from centuries of visual communication design! 🎨

Computational biology = professional translation! Biological questions → math problems → computational analysis → biological insights. We're interpreters! 🔄

August goals: improve data viz skills, explore new computational approaches, and keep building connections in the research community! 📈

Love this perspective from Taschen's infographics history: every era had to solve the problem of making complex data understandable. Same challenge, evolving tools! 📈

Appreciation for Streamlit! It makes building interactive data apps incredibly accessible! No web dev expertise needed to make analysis tools 🚀

Computational thinking: breaking down complex biological questions into manageable components. It's problem-solving methodology beyond just programming! 🧠

Reading about historical cartography: maps were the original interactive data visualizations! Navigation, territory, resources all encoded visually 🗺️