Another year is gone & I grow old and proud of the work of my team @cellcommlab.bsky.social To celebrate the 6th labversary, we did the best we can do: we submitted...now to cross fingers & to press F5. OK, to celebrate we also had pizza as tradition dictates ;) #CellMigration & pizza lovers 🧪🔬
Pablo J. Sáez
@pjsaez.bsky.social
Husband - Dad of 2 - Scientist 🇨🇱 Chilean expat. I love to study how cells walk & talk. PI of the @cellcommlab.bsky.social #CellMigration #CellComm #calciumsignaling #organelles 🧪🔬
Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P
Why adaptive immunity?
Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...
rdcu.be
Why adaptive immunity?
For @science.org , I wrote about brain-eating amoeba 🦠 and fascinating new research led by @katrinavelle.bsky.social which could help explain how the usually harmless pond-dweller ends up in the brain. www.science.org/content/arti...
‘Brain-eating amoeba’ appears to love crawling into narrow spaces
Claustrophilic behavior may help Naegleria fowleri find food—and accidentally travel up the human nasal cavity
science.org
#cytoskeleton So, there is a small (very small) 9-aa motif that is an evolutionary conserved anchor to actin. It's named: short linear actin filament-binding motif (SFM), and it's *the same* found in LifeAct ! Full: www.nature.com/articles/s41... @natcellbio.nature.com @cellclub.bsky.social 🧪🔬
#DAMPsPower!! Excited to share the 💥new 💥 review @ Science Immunology that @marcodigioia & I wrote about the immunological activities played by host-derived oxidized lipids in controlling infections & tumorigenesis! doi.org/10.1126/scii...
Regulation of inflammation by oxidized lipids
Lipids generated by oxidative stress and their effects on immunity and cancer are reviewed.
doi.org
Ready for the next step in your scientific career? Apply now for a fully funded Biozentrum PhD Fellowship and explore a wide range of research fields before choosing your PhD lab. 🧪 Applications for the current call are open until October 18, 2026. More information 👇
Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
biozentrum.unibas.ch
We invite you to submit your latest research to our upcoming special issue: Proteostasis. This issue will be coordinated by two of our Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. journals.biologists.com/jcs/pages/pr...
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
Booking is OPEN for Frontiers in BioImaging 2026! Sessions will span technical developments in light and electron microscopy, advances in image analysis and data interpretation, and biological applications across scales. Register now: https://ow.ly/ZN3950Zuj9j
In the next session, we will discuss chapter 3 on August 12th, 2026 at 16h CET. @r3rt0.bsky.social @k4tj4.bsky.social www.crowdcast.io/c/brain-in-t...
Reading club: The Brain in Theory by Romain Brette
Register now for Reading club: The Brain in Theory by Romain Brette on crowdcast, scheduled to go live on September 23, 2026, 10:30 AM GMT+2.
crowdcast.io
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
cell.com
Watch a muscle fiber take shape. 🔬 This microscopic video captures a muscle cell fusing with a developing muscle fiber, with cell membranes visible in purple and yellow. The Rando Lab uses live-cell imaging to understand how cells coordinate muscle regeneration. Credit: Tamas Nagy/Rando Lab
📢 JOB ALERT! 📢 I am recruiting a 30-month postdoc to work on modelling the vision of trilobites @hfspo.bsky.social ! If you like 3D data, fossils, and functional morphology, this is the one for you! 📆Deadline 27. Aug Pls contact me with any Qs and share widely! www.bristol.ac.uk/jobs/find/de...
Details | Working at Bristol | University of Bristol
bristol.ac.uk
Decades ago in 🇨🇱 cellbio meeting immunologist delivers a ppt with 90% immuno and 10% cellbio. Everyone baffled. 1st row sitting senior PI rise the hand: -why did you come to this cellbio meeting? -yeah I wonder the same sometimes (laughs nervously) -I'm not joking, why?! This 👇🏽 is magnificent too
Speaker refused to divulge the name of compound X in Q&A after his ASCB talk. Questioner [who will be known to many cell biologists] blew a raspberry into the mic and gave the speaker the finger.
This afternoon's imaging lab at #IALSJanelia is all about subcellular structures, highlighted here by myosin (white) and actin (orange). These membrane ruffles were captured on our lattice light-sheet microscope by @cmhobson.bsky.social
Our work on Trichoplax locomotion and mechanosensing capabilities is out now in @currentbiology.bsky.social. Congrats Marvin Leria & all co-authors! authors.elsevier.com/c/1n8Ig3QW8S...
Michaud, @andrewgoryachev.bsky.social, von Dassow, @xenresearchcenter.bsky.social et al. identify a versatile cortical pattern-forming circuit based on #Rho, F-#actin, Ect2, & RGA-3/4 rupress.org/jcb/article/... 📕 In "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...
This is not AI. This is real microscopy! 🔬 An intact gut, rendered transparent and imaged in 3D using light-sheet microscopy! 🤓 Looking inside organs to investigate where pathogens, immune cells, or disease processes may persist. More at: www.nature.com/articles/s41... Happy #FluorescenceFriday!
Microscopy beautifully reveals the dynamic nature of biology but quantifying that motion can be tricky! In the latest paper from @aicjanelia.bsky.social, out now in @jcellsci.bsky.social, we present a tool for measuring amorphous motion: OpticalFlow3D journals.biologists.com/jcs/article/... (1/7)
OpticalFlow3D – a tool for measuring amorphous motion in three-dimensional fluorescence microscopy images
Summary: Biological motion can be difficult to define and measure. Optical flow is uniquely suited to this challenge. We provide tools for 3D optical flow and illustrate its use in extracting biologic...
journals.biologists.com
What does frontier science look like? 🧪 At #HFSPmtg2026, it spans everything from cell migration and photosynthesis to evolution, plant biology or ocean microbiomes. Different questions. Different approaches. One community exchanging ideas across disciplines! 💪 #HFSP #sts
Another #FluorescenceFriday. When the world is going crazy, I find some peace watching at these myeloid cells (🔴) going about their day. They exist in tissue surrounded by other cells (🔵), and you can see them popping up and down, going in and out of plane as they explore their surrounding.
Bringing together science & art, @manuelthery.bsky.social & the CytoMorpho lab describe their project on how cells adapt their shape to their environment using the Musée d’Orsay as their template! The full performance was presented over two nights at the museum earlier this year. #sciart #cellbio
Living Architectures - FocalPlane
Living Architectures - Case studies
focalplane.biologists.com
Bile acid retention in efferocytic #macrophages shapes their inflammatory status during #cholangitis. New study from Amirah Al Jawazneh, Imke Liebold, Stephanie Leyk, Lidia Bosurgi (Universitätsklinikum Hamburg Eppendorf) et al.: rupress.org/jem/article/... @pjsaez.bsky.social #inflammation
I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...
My Peer Review of The 1%
I wanted to like QED's new 1% ranking. I don't.
open.substack.com
I know for a fact that this list is 100% human-generated! For that reason, there are almost certainly some excellent research that I've missed.... Drop me a message if you have any suggestions that I should add to the list.
📢Check out our latest preprint list on FocalPlane In this list, we focus on the latest tools and techniques in imaging, including sample prep, probes, hardware and software. focalplane.biologists.com/2026/06/26/m... Let us know if you've been reading a preprint that we should add to our list.
Applications are open for the international course “Developmental Biology” organized by the Institut Curie in partnership with @sorbonne-universite.fr 📅 Oct. 19–28, 2026 (Paris) ⏳ Jul. 19 & Sept. 18 🔗 training.institut-curie.org/courses/developmental-biology-2026
Sometimes I just like looking back at my old data and see if I'd spot something I've missed. And more often than not, I become more appreciative of the result. Here is a wound healing assay of transformed melanocytes from 10yrs ago. They do look like neurons! not quite #fluorescencefriday but cool!
Every few minutes, a dragonfly dives into water and takes off again, turning several forward somersaults as it ascends. The purpose of the behavior? The quick dip cools the insect down, and the loop-the-loops help it dry off by flicking away the water. https://scim.ag/3Vw2Df1 #InsectWeek