James Munday

@jdmunday.bsky.social

Infectious disease epidemiology and surveillance based in Basel • jdmunday.github.io

Our paper on the transmission dynamics of Noro- and Enterovirus during the COVID-19 pandemic just came out: www.sciencedirect.com/science/arti... We measured wastewater viral loads, estimated Re and assessed the impact of non-pharmaceutical interventions on the transmission of these pathogens.

Transmission dynamics of Norovirus GII and Enterovirus in Switzerland during the COVID-19 pandemic (2021–2022) as evidenced in wastewater

Noroviruses and enteroviruses are major causes of endemic gastrointestinal disease associated with substantial disease burden. However, viral gastroen…

sciencedirect.com

In this project led by James Munday, we quantified the post-sampling degradation of viral RNA in wastewater. Taking into account this degradation is core towards unbiased quantification of epidemiological dynamics based on wastewater data.

James Munday@jdmunday.bsky.social · last yr.

We have a new preprint 📝 *Post-sampling degradation of viral RNA in wastewater impacts the quality of PCR-based concentration estimates* Now on bioRxiv doi.org/10.1101/2025... with @tanjastadler.bsky.social, trj2.bsky.social, Christoph Ort and others

Other (Barcelona, Spain) We seek a highly motivated data scientist to co-create harmonised datasets and dashboards for decision-support. More details: http://iddjobs.org/jobs/we-seek-a-highly-motivated-data-scientist-to-co-create-harmonised-datasets-and-dashboards-for-decision-support

📣 #fundedPhD in "Modelling salivo-surveillance for detecting population immunity, transmission dynamics & changes in vaccine effectiveness" #IDsky #EpiSky #PhDSky 🧪 👥 Supervised by @3113n.bsky.social + colleagues at Uni. of Bristol & UKHSA 🗓️ Closes 27 Jan 2025. Interviews Mar 2025. Start Sep 2025.

About the Project.
Vaccination is a highly effective public health intervention that prevents morbidity and mortality. The UK vaccination programme evolves in response to vaccine developments and emerging evidence. This may include the addition of new vaccines, or removal of old vaccines or booster doses. Following a modification to the vaccine schedule, there is a delay before the impact on key indicators such as diagnosed cases, hospital admissions and deaths is observed. This delay hampers the responsiveness of public health action. We are developing saliva-based tests that will facilitate rapid, repeated sampling to measure both carriage of respiratory pathogens and mucosal immunocorrelates, and thus detect changes in population immunity before disease cases present. The aim of these tests is to develop a surveillance programme that will provide an early warning system for lapses in population-level protection and allow for adaptive management of the UK vaccine schedule.Project aims: The aim of this PhD is to use data analytics, data linkage and mathematical models to inform the use and necessary test characteristics of saliva-based tests for vaccination evaluation. The aims of the project are to:

- Develop transmission models for vaccine-preventable respiratory pathogens (Streptococcus pneumoniae and Respiratory Syncytial Virus) and emerging threats (Group A Streptococcus) in the UK.

- Identify opportunities for early identification of changes in population immunity that would provide a rapid assessment of vaccine effectiveness and coverage.

- Explore the trade-offs involved in detecting population protection.

Methods:
This PhD will use data analysis, statistical and mathematical modelling to inform the use of a rapid and scalable test to measure changes in vaccine coverage and population protection. The methods will involve data analysis, visualisation and code development using software such as R, describing immunological process of transmission mathematically, reviewing and interpreting the literature and working with and maintaining an inter-disciplinary network of collaborators. In year 1, you will work with immunologists to use immunological data to develop data-driven mathematical models of the dynamics of transmission, carriage and infection for respiratory infectious diseases. In year 2, you will design models that link vaccination, disease transmission, carriage and healthcare usage. In year 3, you will explore the impact of changes to the vaccine schedule on population immunity and subsequently invasive disease and determine the necessary test uptake and characteristics needed to provide an early indication of changes to population immunity. There will be scope for the successful candidate to shape the research.Supervisors: Professor Ellen Brooks-Pollock, Dr Anu Goenka, Dr Mary Ramsay (UKHSA) & Dr Bassam Hallis (UKHSA).

Advisory team: Dr Rajeka Lazarus, Dr Clare French, Dr Amy Thomas, Dr Leon Danon, Dr Alice Halliday.

Candidate requirements: This is a unique opportunity for a quantitative scientist to join a multi-disciplinary team and work closely with clinicians, lab scientists and policymakers. Applications are sought from high performing individuals who have, or are expected to obtain, at least a 2.1 degree (or equivalent) in a quantitative subject (e.g. maths, statistics, physics, computer science, biological sciences) together with an interest in public health and multi-disciplinary research. Possession of a relevant Master's degree or research experience would be advantageous but is not required.

We welcome applications from those with non-standard qualifications who can demonstrate knowledge, experience and skills developed in the workplace, or elsewhere, relevant to the programme of study.How to apply: When applying, candidates must search for and select the ‘Population Health Sciences PhD’ programme and enter supervisor names as listed under the project title for which they are applying. Please state Health Protection Research Unit in Evaluation and Behavioural Science in the funding box. Full details on what to include in your application can be found in the Admissions Statement.

Personal statement: Please provide a personal statement that describes your training and experience so far, your motivation for doing a PhD, your motivations for applying to the University of Bristol, and why you think we should select you. We are keen to support applicants from minority and under-represented backgrounds (based on protected characteristics) and those who have experienced other challenges or disadvantages. We encourage you to use your personal statement to ensure we can take these factors into account.

Funding Notes: The studentship is fully funded by Health Protection Research Unit in Evaluation and Behavioural Science (HPRU-EBS) for three years. The funding covers tuition fees for home students and a stipend at the UKRI rate (£19,237 in 2024/2025).

Overseas students are very welcome to apply, please include in your application if you are able pay the difference between the home and overseas fees. If you are unable to cover these costs, we can look into other options to cover these.

Deadline: Applications for this project will close at 16:00 GMT on Monday 27th January 2025. Interviews will be in March 2025 . The anticipated start date is September 2025.

Contact: If you have questions about the project, please contact the supervisors. If you need help with your application, contact admissions at fohs-pgadmissions@bristol.ac.uk.
Ellen Brooks Pollock@3113n.bsky.social · 2y ago

We are advertising an exciting PhD position with a super team: Modelling salivo-surveillance for vaccine programmes. Happy to answer questions. With @anu_goenka @leondanon.bsky.social @rajlaz.bsky.social www.findaphd.com/phds/project...

Postdoc (Berlin, Germany) Vaccine or outbreak modelling. With Stefan Flasche at @cmmid More details: http://iddjobs.org/jobs/experienced-postdoc-in-vaccine-or-outbreak-modelling