Jeff Lange
@jeffjlange.bsky.social
Microscopist, biologist, chemist Opinions expressed are my own.
Did Thoreau encounter contagious cancer? A new study finds transmissible tumors in catfish--and raises questions about whether they could arise in humans someday. Gift link: nyti.ms/4whfi6v
Deep in This Lake, a Contagious Cancer Is Spreading (Gift Article)
Transmissible tumors have been reported in a handful of animal species, but never before among fish. Is it possible in humans?
nyti.ms
You might call them fire flies, but I call them lightning bugs, either way there's a whole lot of them!
Has anyone observed mNeonGreen getting brighter after photobleaching?
🚨Preprint alert! If you you’ve been following the centromere field recently, you’ve seen some (excellent) work showing that repeat copy number is highly variable in centromere region leading to massive variation in size. Here we try to understand how that variation impacts centromere functionality:
Pericentromeric repeat copy number tunes heterochromatin dosage to control chromosome segregation and gene expression in fission yeast https://www.biorxiv.org/content/10.64898/2026.05.08.723760v1
Pericentromeric repeat copy number tunes heterochromatin dosage to control chromosome segregation and gene expression in fission yeast https://www.biorxiv.org/content/10.64898/2026.05.08.723760v1
pmc.ncbi.nlm.nih.gov/articles/PMC... Researchers are exploring the possibility that eating a "false morel" that generates a toxin (gyromitrin) gave rise to a cluster of ALS cases in a small town in the French Alps. This paper specifically identifies the mushrooms. G. venenata and G. esculenta.
Has anyone tried Solid Phase MicroExtraction (SPME) for lipids analysis? If so, what kind of SPME fiber did you use?
Transposable elements determine 3D genome organization—beyond CTCF binding #TEsky link.springer.com/article/10.1...
Dissecting the contribution of transposable elements to interphase chromosome structure - Genome Biology
Background Transposable elements (TEs) occupy nearly half of the human genome and play diverse biological roles. Despite their abundance, the extent to which TEs contribute to three-dimensional (3D) g...
link.springer.com
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
🚨 Last chance to apply! 🚨Applications for the 2026 Summer Scholars Program close this Friday, 1/16. Spend 8 weeks doing hands-on #research in a world-class lab. 📽️⬇️Hear from former Summer Scholars + APPLY now → bit.ly/3SDVdGo
⏰ Final call! Applications for our #PhD program close December 1. Don’t miss your chance to train with world-class scientists in an independently fully funded program. #GradSchool Apply today → bit.ly/44VM6DI
Several years ago I switched to drinking mostly decaf coffee. I still have a single cup of regular per day, but decaf is part of life now. I went to a coffee shop to do some work and I ordered a decaf carmel latte. This did not go according to plan...
My quote of the day You build on failure. You use it as a stepping stone. Close the door on the past. You don't try to forget the mistakes, but you don't dwell on it. You don't let it have any of your energy, or any of your time, or any of your space. Johnny Cash
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 5 Prompt DEER Pdb 4YXH Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals. Next: PIERCE Suggestions?
I don't use AI on an everyday basis or nearly at all. I have been looking for a paper which I remember that showed expansion of bio samples so large that they are visible to the naked eye. I asked copilot and it found it immediately. It even gave me a real link that worked. I am devastated.
What makes #StowersGrad distinct from other #PhD programs? Our students are not limited to only learning under their PI. Experts throughout the Institute in our 16 Technology Centers offer additional learning opportunities. Learn more + apply now: bit.ly/44VM6DI
A new @sciam.bsky.social feature explores #research from the Halfmann Lab, revealing that our cells contain immune proteins that can instantly form crystals—triggering the cell to sacrifice itself when a virus invades. #SciSky 🔗 Read here: www.scientificamerican.com/article/cell...
Cells Have a Death Switch That Protects Us from Viruses but Also Leads to Aging
A special class of immune proteins protect us from pathogens but also drive inflammation and cell death
scientificamerican.com
It's always funny to see these. The bar for effort on these type emails is so low. I believe in you, you can do it.
Has anyone tried using mesoscope.scripps.edu/beta/index.h... and CellPAINT2D to try to illustrate/simulate phase separation? You can make multivalent interactions, but they don't unbind, at least that I can figure out.
This week is #CRC25 — our annual Crossroads Research Conference! A time for our community to connect, share discoveries, and spark new collaborations. Hear from attendees including @jeffjlange.bsky.social & @juliannahaug.bsky.social ⬇️
Applications for our #PhD program are NOW OPEN! Our independently fully funded program allows students to focus entirely on #research & growth, exploring their own questions while learning from top experts in the field. #GradSchool Apply now: bit.ly/44VM6DI
Cnidarian-Microbe Interactions Fully-funded postdoctoral position is available in the Gibson Lab at the Stowers Institute to investigate any aspect of cnidarian-microbe interactions. Strong background in coral symbiosis or eukaryotic microbiology preferred. Contact Matt Gibson: mg2@stowers.org
A little Friday distraction, is the sound a Mac plays when you turn it on the final chord from A Day in the Life by the Beatles? This is a clip of the song in question. youtube.com/clip/UgkxZZ3...
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Sweet! Very excited to read this paper on the transcriptome AND proteome of stress granules both from yeast and mammalian after treatment with azide/arsenite. www.cell.com/cell-reports... I've always wondered if the contents are there by accident, or on purpose to maintain the phase/granule.
Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes
Demeshkina and Ferré-D'Amaré purify stress granule cores from yeast and mammalian cells. These cytoplasmic ribonucleoproteins are a conserved response of eukaryotic cells to stressors; their dysregula...
cell.com
Meet Jeff Lange, Senior Research Scientist, in this #RoadToResearch Q&A! "I hope to inspire early-career researchers to be curious and, in turn, have a far-reaching impact on humanity and human health as a whole." Read more: bit.ly/3Fd0nVm
Road to Research: Q&A with Jeff Lange, Senior Research Scientist
"I hope to inspire early-career researchers to be curious and, in turn, have a far-reaching impact on humanity and human health as a whole."
bit.ly
I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details. We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy I started this w/ Alex Lichius years ago, tip of the 🧊!