Virus reactivation in acute and long COVID-19 1,154 hospitalised COVID patients, followed up to 1 year. Assessing reactivation of latent viruses (EBV, CMV, HSV, Anelloviridae) using RNA sequencing plus immune, protein and metabolite profiling. www.nature.com/artic... 1/8

Virus reactivation in acute and long COVID-19

Nature - Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune...

nature.com

Is this specific to Covid or is it typical of severe infections in general? I can’t figure out from reading on phone. www.nature.com/articles/d41...

COVID can wake up a slew of dormant viruses inside you

Reactivation of typically harmless anelloviruses, in particular, seems to be linked with developing long COVID, study finds.

nature.com

Cool paper - though it is not at all surprising that plasma cells are in the CSF as implied in the discussion. I thought this was the foundation of the big Stanford nature paper and decades of work on OCBs. www.cell.com/cell/fulltex...

Localized PD-1 CAR T therapy reprograms neuroinflammation

PD-1+ T follicular helper-like cells drive B cell-associated pathology in multiple sclerosis. Programmable PD-1-targeting CAR T cells selectively eliminate these pathogenic CD4 T cells while deliverin...

cell.com

Does every “big” researcher in academia who works on aging and big data have to have a company on the side that aims to monetize this information in some way? Isn’t this a red flag anymore?

www.science.org/doi/10.1126/...

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

Complement component 1q (C1q), the initiator of the classical complement cascade, mediates synaptic elimination in development and disease, yet the triggers for its deposition on synapses remain uncle...

science.org

www.nature.com/articles/s41... 😂😂😂😂😂😂😂😂😂

Large language models can predict the results of social science experiments - Nature

Large language models can be used to estimate the results of social science experiments about as accurately as a group of human forecasters—even for experiments published after the...

nature.com

Critical reassessment of lipophilic dye labeling reveals negligible incorporation into small extracellular vesicles derived form serum-free cultured cells https://www.biorxiv.org/content/10.64898/2026.07.04.722344v1

I’m struck by how often the “limitations” section of cell papers I read say “need more spatial and single cell tech”. Surely we can come up with better limitations 😅

Step 1: Run regression of [scary Y] on [trendy X] using observational data Step 2: Magically "adjust" for the 20 bajillion imperfectly-measured confounders Step 3: Wait for a credulous journalist to write it up as causal www.theguardian.com/science/2026...

Arts and cultural engagement ‘linked to slower pace of biological ageing’

Research from UCL suggests visiting art galleries or museums, singing and painting can help improve health outcomes

theguardian.com

Every cancer atlas I see spends a ton of effort on all the cells in the tumor except the tumor cells 😅🤪

This from @pardoguerra.bsky.social is right: Not every useful unit of research needs the same amount of peer review resources. We need an incentive structure to support alternatives. Not said: there is no way to get there. /1

It’s time to get rid of the peer-reviewed paper

The peer-reviewed journal article, perhaps the single most important device behind the expansion of scientific knowledge in the last century, is an extraordinarily expensive way to share novelty: e…

pardoguerra.org

“On my podcast” are the 3 cringiest words in English at the moment

It’s not review unless it comes from the Review region of France, otherwise it’s just sparkling criticism

Academia feels increasingly like playing Monkey Island, if you miss something as absurd as picking up a rubber chicken with a pulley in the first scene, you only realize much later that you’re stuck and can’t pass to the next stage (👇 see below 1/3) www.science.org/content/arti...

Abrupt change to European funder’s rules leaves researchers shut out

Flood of proposals to European Research Council—perhaps unleashed by AI—means unsuccessful applicants must wait longer to reapply

science.org

I've been getting questions about this paper all week: www.cell.com/cell/abstrac... They make EXTRAORDINARY claims - fortunately, these are trivial to verify/falsify. Unfortunately, there's other concerns.

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression

The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenati...

cell.com

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

I’m excited to share the draft for our perspective piece on »Emergence Biases« that I wrote with @vakirlis.bsky.social on arxiv: arxiv.org/abs/2604.20477

Emergence biases in molecular evolution

Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts such as development and mutation, but not for acquiring new funct...

arxiv.org

My great friend @aginigfencer.bsky.social posted a preprint on JAML (also called AMICA1) which is a very clonal gene in T cells so I feel obliged :) www.biorxiv.org/content/10.6...

This is buttons. I call this move the wiggle worm. I know he’s itching his back but when I say wiggle worm he now does this 😂. I guess I can vocally make him itchy

Two more talks on single cell resolved clonal haematopoiesis research and using methylation patterns to study clonality #MITS2026

This seems really fascinating www.science.org/doi/10.1126/...

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Why do Americans refer to NAD+ as a “peptide” therapy?

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. www.biorxiv.org/content/10.6... 1/

Parse or 10x? any advice? we're thinking about trying Parse but would love some feedback from the #immunology community. this sequencing project is for lung #macrophages if that matters? please circulate and send me any info about your experiences!! @jeffmold.bsky.social have you used Parse?

This is a great paper - even down to the honest way the authors critique their own findings in the final sentence of the results www.nature.com/articles/s41...

Parasites trigger epithelial cell crosstalk to drive gut–brain signalling - Nature

Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occu...

nature.com

Cool demonstration of possible role of clonal heritability in cancer in mice - but not novel to show clonal heritability is a persistent driver of heterogeneity within cell types… www.nature.com/articles/s41...

Epigenetic memory of colitis promotes tumour growth - Nature

Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

nature.com

A new mechanism for “RNA memory”! This time in Planaria! (Here's a video of a Planarian with mulitple heads, one of the heritable phenotypes we studied). This work summarizes >10 years of research and is an amazing collaboration with the labs of Jochen Rink and Omri Wurtzel labs. Read thrad below👇

Aging may feel gradual… but what if it’s not? In our recent paper, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

I wish some stats or comp bio labs would get together and draft a best practices paper on how to normalize and represent big omics datasets in published papers. The units people use in figures are out of control