Compete set of illustrations from #singlecellgenomicsday a great event for the genomics community, open to all. Happy 10th anniversary!
Alex Cagan
@atjcagan.bsky.social
Researching somatic evolution at the University of Cambridge and Wellcome Sanger Institute. Also a scientific illustrator.
Live illustrations from the special 10th anniversary edition of #singlecellgenomicsday
Single Cell Genomics Day: A (Virtual) Practical Workshop. June 12, 2026, organized by @nygenome.org's Rahul Satija Free, livestreamed, no registration.
Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
rdcu.be
Carl de Boer on understanding the evolution of gene regulatory complexity and its role in complex disease #MITS2026
A whole new world… Inigo Martincorena presents paradigm shifting work showing a key role for somatic evolution in autoimmune disease. Long-term, polyclonal, multistage evolution #MITS2026
Nicole Lake on constraint in mitochondrial genomes with insights into health and evolution #MITS2026
Talks exploring the heritability of mutational processes and inferring de novo mutation rates across primates #MITS2026
Evan Eichler on using near-complete human genomes to more fully understand mutational processes #MITS2026
Hakon Jonsson on insights into de novo genetic variation and genetic causes of pregnancy loss #MITS2026
Two more talks on single cell resolved clonal haematopoiesis research and using methylation patterns to study clonality #MITS2026
Caroline Watson gives the first talk at the Mutations in Time and Space conference on the evolutionary road to AML #MITS2026
Delighted to have contributed a comment piece and the cover illustration to a @natecoevo.nature.com focus issue on "Evolution in medicine". I discuss how the emerging field of somatic evolution is providing new opportunities to understand disease and promote healthy ageing doi.org/10.1038/s415...
Our March issue is a Focus on "Evolution in medicine", out now! www.nature.com/natecolevol/... Including research & opinion on: ➡️Somatic evolution and health ➡️Predicting intrahost evolution ➡️Collateral sensitivity during antibiotic therapy Cover illustration by Alex Cagan @atjcagan.bsky.social
Thrilled to announce that I'm on Curious Cases tomorrow at 10am on BBC Radio 4! The episode - Immortal Jellies - looks at some remarkably long-lived species and what they can teach us about ageing. This is a key area of focus for our lab. www.bbc.co.uk/sounds/play/...
Curious Cases - Series 24 - Immortal Jellies - BBC Sounds
Hannah Fry and Dara Ó Briain ask whether a tiny jellyfish holds the secret to immortality.
bbc.co.uk
Julie Ahringer from @gurdoninstitute.bsky.social @geneticscam.bsky.social @cam.ac.uk gives talk on decoding genome regulation during development. Exploring how chromatin accessibility changes throughout development enable single cells to become multicellular organisms.
This is a fantastic opportunity to do exciting research on comparative somatic evolutionary genomics as part of a great team. I've collaborated with Peter for many years and highly recommend this position! Please email Peter if you'd like to learn more, including a copy of your CV.
The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052
Closing keynote from the fabulous @atjcagan.bsky.social on "The impossibility of whales" discussing somatic mutagenesis across species. Brilliantly delivered and exceptionally illustrated talk, as anyone who knows Alex's work would expect! #EBECancer25 @eventswcs.bsky.social
Thanks @amyboddy.bsky.social for the invitation to run this workshop on where ideas come from in science, barriers to creativity and how to overcome them. Great discussion from the group! I'm a convert to 'night science' @urialonlab.bsky.social
Late night session on how to think of good ideas!! #EBECancer25 @atjcagan.bsky.social discusses the creativity in science & helped us practice different ways to think and talk about our science.
The Somatic Mosaicism across Human Tissues Network @nature.com @timcoorens.bsky.social www.nature.com/articles/s41...
If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...
A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects
Mutational signatures contain valuable information about the mutational processes shaping cancer genomes. However, despite dozens of tools to identify signatures in cancer samples, there is not an est...
biorxiv.org
A new review paper for those interested in how comparative approaches are informing cancer research. Advances in genomic resources for non-traditional model organisms (whales, bats, and beyond!) is set to transform our ability to gain insights from cancer resistant species. doi.org/10.1038/s415...
Advancing cancer research via comparative oncology - Nature Reviews Cancer
Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms un...
doi.org