Collecting recent-ish papers for a Cell Bio 101 course I'm teaching this fall. Ideally microscopy-driven breakthroughs that are also experimentally elegant and well written. Any favourites I should check out? 🔬
Juan C. Landoni
@jclandoni.bsky.social
Mitochondria | Metabolism | Microscopy 🔬 Landoni Lab, University of Lausanne 🇨🇭 landonilab.org
🔬🔦In our latest Imaging spotlight, @jclandoni.bsky.social takes us through his recent papers dissecting mitochondria organisation. Juan discusses why they needed to employ multiple imaging approaches to unveil events that had not previously been observed. focalplane.biologists.com/2026/07/21/p...
Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture - FocalPlane
Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture - News
focalplane.biologists.com
Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology. New study from Julius Winter (@julius-w.bsky.social), Juan C. Landoni (@jclandoni.bsky.social), Suliana Manley (@sulianamanley.bsky.social) et al. (EPFL): rupress.org/jcb/article/... #Mitochondria
Still buzzing from #EUROMIT2026. What a reminder of how exciting and inspiring the #mito -community is, and an honour to present my work (and my new lab!) to this amazing crowd. What a week, thank you all! #Euromit2026 #Mitochondria
Check out this amazing video by @julius-w.bsky.social (lead author) summarising our paper out this week! doi.org/10.1083/jcb....
Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology
Winter et al. use substrate micropatterning and photoactivation to define mitochondrial subpopulations in proliferative cells. They find that biased antero
doi.org
Julius Winter@julius-w.bsky.social · 2mo agoI made a video summary of our recent paper on mitochondrial trafficking. 🔬🧫🧬Check out the paper here: doi.org/10.1083/jcb.... @jclandoni.bsky.social @sulianamanley.bsky.social @jcb.org youtu.be/Az8xzdO0nVU?... #mitochondria #imaging #fluorescence #organelle
@julius-w.bsky.social @jclandoni.bsky.social @sulianamanley.bsky.social et al reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...
We had such a fun ERC Synergy @erc.europa.eu kickoff workshop for our 6-year MitoContact collaborative project with our partners Kai Johnsson and Wanda Kukulski! Wonderful to share science, ideas, and play games together 💚 fantastic organization by @zimmerli.bsky.social @jclandoni.bsky.social
My first corresponding author 🔬🎸🦾 rupress.org/jcb/article/... Ever wonder what the ultrastructure of dopaminergic neuron presynaptic sites looks like? Using cryo-CLEM/ET we observed the wild changes that happen at these sites when the neurons fire or are more quiet. In the latest @jcb.org
Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy
Lycas et al. develop a cryo-CLEM workflow to characterize the ultrastructure of dopaminergic varicosities. They resolve in situ structures of TRiC/CCT and
rupress.org
We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social
Juan C. Landoni@jclandoni.bsky.social · 4mo agoThe Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
Juan is awesome! If you like mitochondria and imaging you should work with him
Juan C. Landoni@jclandoni.bsky.social · 3mo agoWe're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social
We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social
Juan C. Landoni@jclandoni.bsky.social · 4mo agoThe Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
Trainees jump on this! Juan is an awesome human and he’s gonna do some amazing science ✨ Can’t wait to see what he gets up to!
Juan C. Landoni@jclandoni.bsky.social · 4mo agoThe Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/ www.pnas.org/doi/10.1073/...
Diffusive spreading across dynamic mitochondrial network architectures | PNAS
In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...
pnas.org
The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
My favorite paper in 2026 so far!! Absolutely stunning 🤩
Juan C. Landoni@jclandoni.bsky.social · 4mo agoOur paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Mitochondria use a shape-shifting process called "pearling" to evenly distribute their DNA, supporting cellular health and offering new insight into mitochondrial genome organization.
How mitochondria organize our 'second genome'
EPFL scientists have discovered that a simple shape change in mitochondria helps cells evenly distribute their mitochondrial DNA, solving a long-standing puzzle.
phys.org
Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...
Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
science.org
Wonderful and honoured to write a perspective with @prudentlab.bsky.social @mrc-mbu.bsky.social on such an intriguing and cool observation of beautiful mitochondrial biology! Amazing work on how pearling allows mitochondrial genome organisation by @jclandoni.bsky.social @sulianamanley.bsky.social!
Juan C. Landoni@jclandoni.bsky.social · 4mo agoCheck out the fantastic perspective by @jellevda.bsky.social & @prudentlab.bsky.social on our #pearling work, out in the same @science.org issue! www.science.org/doi/10.1126/...
Check out the fantastic perspective by @jellevda.bsky.social & @prudentlab.bsky.social on our #pearling work, out in the same @science.org issue! www.science.org/doi/10.1126/...
Mitochondrial genomes on a string of pearls
Transient membrane constrictions, or “pearling,” underlie the regular spacing of mitochondrial genomes
science.org
Juan C. Landoni@jclandoni.bsky.social · 4mo agoOur paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Easter edition of #Mitochondria in #Health and #Disease! 🐰🐣 biomed.news/bims-mitdis/... @gavinmcstay.bsky.social @mitoscientist.bsky.social @biomednews.bsky.social @mitoscientists.bsky.social Perling drives mtDNA nucleoid distribution www.science.org/doi/10.1126/...
Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
science.org
See how PKMito dyes promote mitochondrial research😀 @spirochrome.com
Juan C. Landoni@jclandoni.bsky.social · 4mo agoOur paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Could this organelle get any cooler? 🤩 Check out this incredible paper by the Juan and only @jclandoni.bsky.social
Juan C. Landoni@jclandoni.bsky.social · 4mo agoOur paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
The longstanding mystery for how mitochondria segregate and position their DNA has been solved! Read all about it: www.science.org/doi/10.1126/... @jclandoni.bsky.social Here is Juan and I at the 4th of July parade at MBL physiology
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
“Why Did This Evolve? It Didn’t. It Was Already There” - @jclandoni.bsky.social 👉 www.iflscience.com/why-did-this...
🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪 www.annualreviews.org/content/jour... #Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
