1/ AI can design biology faster than wet labs can build it. What if the wet lab fit on a hospital countertop? Invitris (a 2018 iGEM spinout from TU Munich) is testing how far cell-free phage production can go.
Jessica Sacher
@jessicasacher.bsky.social
phage therapy scientist at Stanford, building community at Phage Directory, writing about adventures from the lab to the clinic -> https://jess.bio
NIAID (@niaidnews.bsky.social) has awarded $6M to launch a coordinated US phage therapy research network — 3 new centers! Excited our Stanford Center for Phage Pharmaceuticals (@stanfordmedicine.bsky.social) is one, & to work w/ @gladstoneinst.bsky.social & @pghphageprogram.bsky.social! 🧵 1/
1/ "Why can't phage companies attract $400M rounds?" Locus Bio CEO Paul Garofolo thinks the answer is uncomfortable: too many small, underpowered trials producing mediocre data have cooled investor confidence across the whole field. Why? And how do we fix it?
1/ Chip Schooley (cofounder of UCSD's IPATH) was there when HIV went from “some people benefit” to functionally cured. His take: phage therapy is at about 1988 on that timeline. How do we get it into the 90s?
Excited to see @dariavantyne.bsky.social and Van Tyne Lab featured on the Podovirus Podcast! Great conversation on how translational phage work actually gets done. 🧫 Check out the links below for the full story! #pittsburghphageprogram #p3 #phages #infectiousdiseases #phagetherapy
Jessica Sacher@jessicasacher.bsky.social · 7mo agoIn 2018, @dariavantyne.bsky.social started her phage lab at @pittdeptofmed.bsky.social. She had 0 phages, just knew their biology & wanted to help patients. Today her lab makes phage for dozens of patients/year under compassionate use, while still publishing research. We asked Daria: HOW? 🧵1/
In 2018, @dariavantyne.bsky.social started her phage lab at @pittdeptofmed.bsky.social. She had 0 phages, just knew their biology & wanted to help patients. Today her lab makes phage for dozens of patients/year under compassionate use, while still publishing research. We asked Daria: HOW? 🧵1/
🧬 Big Pharma's antibiotic problem: A successful drug + FDA approval = $776M loss Here's how that happens 🧵
Laughed out loud — phage field, there’s still hope for us 😂 Source: Kate Zernike’s The Exceptions — highly recommend, cannot put it down!!
Hello 🦋 #protein / #microbio / #BioML community! We are excited to release Gaia🌎, a context-aware protein search tool, extending protein search and discovery capabilities beyond sequence and structure, to include *genomic context*. Search your favorite protein sequences with on gaia.tatta.bio
Do you feel stressed? Is it one thing or a combination? Turns out bacteria can’t handle stress either! Excited to share my first first author paper out now in @currentbiology.bsky.social! Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
A review on "Bacterial Organelles in Iron Physiology" from Hualiang Pi et al. Joe Neilands (a siderophore pioneer) once stated that Fe was too important for bacteria to export. Bacteria DO export Fe, but they can also store it in organelles. #MicroSky onlinelibrary.wiley.com/doi/10.1111/...
Bacterial Organelles in Iron Physiology
A proposed model of iron trafficking during ferrosome formation.
onlinelibrary.wiley.com
Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n
Xue lab at UC Irvine
Ecology and evolution in the human gut microbiome
kxuelab.com
Trying to purify and sequence #phage for phage therapy? Try #sphae a new approach to identify if your phage could be useful for treatment #phagesky
bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 2y agoSphae: An automated toolkit for predicting phage therapy candidates from sequencing data https://www.biorxiv.org/content/10.1101/2024.11.18.624194v1
Honoured to have been voted as President-elect of the International Society for the Viruses of Microbes (ISVM) and excited to work with the Executive Board over the next few years #phagesky phagesociety.org
ISVM – International Society for Viruses of Microorganisms
phagesociety.org
When applying to NSF for funding, each senior personnel has to provide a “Collaborators and Other Affiliations” (COA) form, which can be quite onerous. A couple of years ago I created a tool bit.ly/NSF_COA for automating this, and recently hardened it. I hope it is of use, and feedback is welcome! 🧪
NSF COA generator
bit.ly
Welcome! I created the account a while ago but paying attention since yesterday. I have found three phage phlocks so far: 1. #phagesky list 2. Starter pack bsky.app/starter-pack... 3. Starter pack bsky.app/starter-pack...
Phage friends, I’ve been told you’re all here?! Yay! What lists should I join? Complete newb 😳
