Gladstone Institutes
@gladstoneinst.bsky.social
To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.
The company has been working with Steve Finkbeiner's team at Gladstone since January to search for molecules targeting alpha-synuclein, a protein involved in Parkinson's disease.
Topos Bio launches two AI models for hard-to-target proteins
Less than a year after emerging from stealth with an AI model for tracking the ...
firstwordpharma.com
Steve Finkbeiner discusses the remarkable potential of AI to advance science—and the risk of too-stringent government regulations on AI hampering discovery.
How AI could usher in a 'new scientific golden age' (if it doesn't kill us all first) | CBC News
AI has remarkable potential to exponentially advance scientific discovery, say scientists. But getting out the word of its scientific benefits of can be challenging when forced to compete with headlines about its significant if not existential threat to...
cbc.ca
Seth Shipman (@seth-shipman.bsky.social) )has been recognized for pioneering molecular technologies that record cellular activity, expand genome editing, and target antibiotic-resistant superbugs. @calacademy.bsky.social
Gladstone’s Seth Shipman Named Fellow of the California Academy of Sciences | Gladstone Institutes
Shipman is recognized for pioneering molecular technologies that record cellular activity, expand genome editing, and target antibiotic-resistant superbugs.
gladstone.org
Researchers from Melanie Ott's lab identify the SARS-CoV-2 protein ORF8 as a driver of lung inflammation, revealing how infected macrophages may worsen severe COVID-19. @theottlab.bsky.social
SARS-CoV-2 Protein Fuels Lung Inflammation by Hijacking Macrophages
Researchers identify the SARS-CoV-2 protein ORF8 as a driver of lung inflammation, revealing how infected macrophages may worsen severe COVID-19.
genengnews.com
Gladstone swept this year's UCSF Postdoc Slam 🏆 🥇 Yolanda Martí-Mateos (Jain Lab) shared how red blood cells at high altitude could unlock new diabetes treatments. 💙 Shoshana Williams (Ott Lab) received the People's Choice Award for a CRISPR test strip that could speed up TB diagnosis.
Why This One Small Blood Cell Is Your Secret to Living the High Life
Image
ucsf.edu
🚨 NEW PUBLICATION 🚨 "Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes" @seth-shipman.bsky.social @jihoon-han.bsky.social @natbiotech.nature.com
Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes - Nature Biotechnology
RNA sequences are detected and converted directly into DNA barcodes.
nature.com
Gladstone's Jeanne Paz reflects on her early-career years in the lab of 2026 Nobel Prize winner Karl Deisseroth and explains how optogenetics has advanced epilepsy research.
Nobel Prize-winning optogenetics revolutionized neuroscience
The technique enables neuroscientists to target brain circuits with unprecedented specificity, transforming the study of memory, reward and more.
thetransmitter.org
Inspired by bacterial biology, the Gladstone-developed “Detectron” opens up new possibilities for disease research and potentially treatments. New from the lab of @seth-shipman.bsky.social
Novel Biosensor Uses DNA ‘Barcodes’ to Uncover Disease Signals in Cells | Gladstone Institutes
Inspired by bacterial biology, the Gladstone-developed “Detectron” opens up new possibilities for disease research and potentially treatments.
gladstone.org
📣📣 Looking for new faculty @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social Genomic Immunology: aprecruit.ucsf.edu/JPF05958 We are broadly interested in immunotherapy - discovery, design, engineering, and translation, across the full spectrum of modalities and disease indications.
In Residence/ Ladder Faculty - Gladstone-UCSF Institute of Genomic Immunology
University of California, San Francisco is hiring. Apply now!
aprecruit.ucsf.edu
Machine learning and statistical methods for molecular quantitative trait loci go.nature.com/4d9DTTi New #Review by @barbaraengelhardt.bsky.social @gladstoneinst.bsky.social, Joshua S. Weinstock @emoryuniversity.bsky.social, Sarah K. Nyquist & @alexisbattle.bsky.social @jhu.edu out now!
Machine learning and statistical methods for molecular quantitative trait loci - Nature Reviews Genetics
Molecular quantitative trait loci (molQTLs) provide key insights into how non-coding variants shape complex traits and disease. In this Review, the authors outline statistical and machine learning app...
go.nature.com
Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes - @seth-shipman.bsky.social @gladstoneinst.bsky.social www.nature.com/articles/s41...
Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes - Nature Biotechnology
RNA sequences are detected and converted directly into DNA barcodes.
nature.com
It's Down Syndrome Awareness Month. Nearly 50% of babies with Down syndrome are born with heart defects. Our scientists used stem cells + gene editing + AI to find the gene behind it.
Science in Seconds | Researchers Pinpoint Key Gene Behind Heart Defects in Down Syndrome | Gladstone Institutes
In this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome--and how reducing its levels in mice restored normal heart development, offering hope for future treatments
gladstone.org
Gilbert Herrera, grad student at the Gladstone-UCSF Institute of Genomic Immunology, has been named the Ellen & Bernard Marson Fellow. The award provides 3 years of support for a promising trainee pursuing innovative immunotherapy research. Read more: https://bit.ly/4hGCrJy
Gladstone is among the early users of Anthropic’s Claude Science platform, which is being used to support new approaches to biological research.
Anthropic Builds Bay Area Wet Lab to Test AI's Real-World Biology Ambitions
Anthropic has opened a wet lab in the San Francisco Bay Area for physical biology experiments, confirmed by its head of life sciences. The facility supports Claude AI's push into protein design and au...
webpronews.com
Gladstone Associate Investigator Seth Shipman shares his thoughts on Anthropic's claim that its scientists used AI to discover new enzymes with promise for biotechnology.
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own?
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
nytimes.com
A team of scientists at Gladstone and UCSF discovered how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread, pointing to a new strategy for therapeutic intervention. Read more: https://bit.ly/4hk8sad
Our Gladstone community came out in force for the San Francisco Heart Walk! We had 91 walkers across 11 teams, and raised $1,766.40 for cardiovascular research. So much gratitude for everyone who walked, donated, and cheered us on. ❤️
It's World Heart Day. Heart failure affects approximately 64 million people worldwide. At Gladstone, Michael Alexanian is asking: what if we could just switch it off? He's found two genes, BRD4 & MEOX1, that may hold the answer.
Ask a Scientist: Can We Turn Off the Molecular Switches That Cause Heart Failure?
Michael Alexanian is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
gladstone.org
Happy Research Administrator Day! Today we’re celebrating the people that make discovery possible at Gladstone. Your work creates the support our scientists need to pursue new ideas and advance their research. Thank you for everything you do behind the scenes to support our our science.
🎉 It's Postdoc Appreciation Week, and we're celebrating the talented scientists who bring so much to our research and community. Postdocs are helping shape the future of science, and we're proud to support them as they grow into the next generation of scientific leaders.
Ayush Midha, a graduate student in the Jain Lab, is uncovering how the body adapts when oxygen runs low—work that has surprising ties to cancer and fertility.
Meet Gladstone: Ayush Midha
Ayush Midha, a graduate student in the Jain Lab, studies how the body's metabolism adapts to low oxygen—work that's uncovered backup energy pathways, potential fertility treatments, and a link between...
gladstone.org
Science is hard — failure is part of the process. Gladstone's Lexi Schneider explains why a strong support system (and hobbies outside the lab!) are just as essential to good science as the experiments themselves
🚨 🚨 NEW PUBLICATION 🚨 🚨 "Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells" @theottlab.bsky.social @ucsanfrancisco.bsky.social
Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dys...
science.org
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread—and points to a new strategy for therapeutic intervention.
How a Single Viral Protein Hijacks Immune Cells to Supercharge COVID-19 Infection
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread--and points to a new strategy for therapeutic intervention.
gladstone.org
Congrats to Gilbert Herrera who was named the inaugural Ellen & Bernard Marson Fellow! Herrera is making key discoveries about how immune cells can fight cancer more effectively.
Rethinking ‘Exhausted' T Cells: Gilbert Herrera Named Inaugural Ellen & Bernard Marson Fellow
The fellowship provides three years of funding for graduate students pursuing groundbreaking immunology research.
gladstone.org
Gladstone researcher Nevan Krogan says the new autism research provides an important roadmap for understanding autism and identifying potential treatments.
Largest ever ‘map' of autism may hold clues for new targeted therapies | CNN
Scientists are getting a step closer to understanding exactly how autism develops in the brain – and what might work to treat it.
cnn.it
Jun Takahashi was selected for pioneering the translation of induced pluripotent stem (iPS) cell biology into regenerative therapies for Parkinson’s disease, culminating in the world’s first clinical approval for iPS cell-derived cell transplantation. Read more: https://bit.ly/3VdWRlo
Nevan Krogan discusses how researchers are connecting hundreds of autism-linked genes to the proteins they affect, helping identify common biological pathways that could lead to new treatments.
Scientists map the interactions of key proteins linked with profound autism
After more than a decade, UCSF scientists have mapped around 100 varied genes associated with profound autism to a smaller set of biological pathways, offering a promising path for developing drugs.
n.pr
🎧 Listen to this story 🎧 An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.
Scientists Decode Gene Circuits of Human Immunity, Fueling New Era of Disease Research
Gladstone Audio News · Episode
open.spotify.com
