Gladstone Institutes
@gladstoneinst.bsky.social
To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.
Hear how Katie Pollard is using AI and genome editing to uncover how tiny changes in our DNA can lead to disease—and why this work could change the future of medicine.
How AI Is Helping Decode Human DNA
YouTube video by Gladstone Institutes
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The next breakthrough starts with the next generation of scientists. Embark empowers early-career researchers with world-class mentorship, leadership development, and the opportunity to tackle some of the biggest challenges in human health. Learn more: https://gladstone.org/embark
deeply honoured and humbled. This really reflects the fantastic scientists that have come through the lab and made wonderful discoveries
Gladstone Institutes@gladstoneinst.bsky.social · 6d agoBenoit Bruneau will receive the American Heart Association's highest scientific honor in November. @americanheart.bsky.social @benoitbruneau.bsky.social
By studying a gene linked to congenital heart defects, scientists uncovered a new mechanism for how small drops in protein levels scramble the 3D structure of DNA, resulting in disease. Read more: https://gladstone.org/news/misfolded-dna-blueprint-new-origin-genetic-disease
What does a day as a biomedical research intern look like? Follow Vincent Chen, a PUMAS intern in the Theodoris Lab at Gladstone Institutes, as he takes you through a typical day.
A new study shows that the TBX5 gene plays a role in physically folding DNA into the architecture that heart cells need to function—and losing one copy dismantles this DNA organization.
Findings From Second Phase of NIH 4D Nucleome Program Spelled Out in New Publications
A suite of new studies is revealing genome organization features and dynamics found in individual cells from a broad swath of tissue and cell types during health or disease.
genomeweb.com
Kazuo Nakamura joined Gladstone as a student intern in the lab of Seth Shipman, where he set out to search for retrons—bacterial defense mechanisms that scientists can harness for genome editing. What began as a teaching project quickly turned into real discovery. #NationalInternDay
From Hiking Trails to the Lab: Discovering New Retrons
Kazuo Nakamura joined Gladstone as a student intern in the lab of Seth Shipman, where he set out to search for retrons--bacterial defense mechanisms that scie...
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Benoit Bruneau will receive the American Heart Association's highest scientific honor in November. @americanheart.bsky.social @benoitbruneau.bsky.social
American Heart Association Honors Benoit Bruneau with 2026 Distinguished Scientist Award
Bruneau, director of the Gladstone Institute of Cardiovascular Disease, will receive the association's highest scientific honor in November.
gladstone.org
Amazing work by GOA convener Dr Zoe Grant! Her study on the impact of the 3D genome in heart disease was just published in Science! Read about it here: www.science.org/doi/abs/10.1...
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor
Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...
science.org
Gladstone Institutes@gladstoneinst.bsky.social · last wk.Congenital heart disease is the most common birth defect. In a new study published in @science.org researchers investigated why losing just one functional copy of the gene TBX5—a genetic cause of congenital heart disease—can have such devastating effects on heart development.
The method to reprogram fully differentiated cells using transcription factors retools cells—and has retooled many a scientist's trajectory. In this piece, researchers comment on this ‘remodeling' and the future they foresee.
iPS cells: history made and history in the making - Nature Methods
The method to reprogram fully differentiated cells using transcription factors retools cells — and has retooled many a scientist’s trajectory. Here, researchers comment on this ‘remodeling’ and the future they foresee.
nature.com
New research links long COVID to changes in virus-specific immune cells, particularly in women.
Long COVID and Immune “Soldier” Cells: A Q&A With Gladstone's Nadia Roan
New research links long COVID to changes in virus-specific immune cells, particularly in women.
gladstone.org
Congenital heart disease is the most common birth defect. In a new study published in @science.org researchers investigated why losing just one functional copy of the gene TBX5—a genetic cause of congenital heart disease—can have such devastating effects on heart development.
Discovery Spotlight│Misfolded DNA Blueprint: A New Origin for Genetic Disease
YouTube video by Gladstone Institutes
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Scientists at Gladstone Institutes have developed a “Thinking Microscope”—an artificial intelligence-powered system that can design, conduct, and refine its own experiments.
This Is AI Designing Its Own Experiments
YouTube video by Gladstone Institutes
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Alex Marson is co-leading a new effort to build a comprehensive atlas of T cell receptors involved in food allergies, laying the groundwork for more precise diagnostics and new therapies.
Food Antigen Atlas for New Regulatory T Cell Therapies in Food Allergy -- Food Allergy Fund
Building on its recent advances with the Chan Zuckerberg Biohub Billion Cells Project, “a project (which) will provide a necessary scale of data to understand the functional effects of human genetic variants and characterize the genetic drivers of human...
foodallergyfund.org
🚨 NEW PUBLICATION 🚨 "Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans" in @ajhgnews.bsky.social
Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans
Using cross-ancestry fine-mapping across global and local ancestry groups, this study dissects the 9p21.3 coronary artery disease locus and shows how ancestry-specific haplotype structure shapes assoc...
cell.com
Science communication should be accessible to everyone. On the anniversary of the ADA, watch this Design Lab episode to learn practical ways to create more accessible documents using Microsoft Word and Adobe Acrobat. Better accessibility means better science communication—for everyone.
Ep 12 | Accessibility in Science Communication
YouTube video by Gladstone Institutes
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POV: You joined the Glad-Scientists at the San Francisco AIDS Walk! Thank you to our 35 amazing team members, everyone who walked, donated, and cheered us on. Every step supports the fight against HIV/AIDS. Special shoutout to @akandrew11.bsky.social for organizing the Gladstone team!
🚨NEW PUBLICATION🚨 Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor in @science.org @benoitbruneau.bsky.social @ucsfanesthesia.bsky.social @ucsanfrancisco.bsky.social
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor
Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...
science.org
For decades, a DNA-based test for cardiovascular disease seemed to work for Europeans and others but not Africans. Gladstone scientists just discovered why, with implications for many other diseases.
Heart Disease Genetic Risk: New Study Reveals Why Populations Differ
For decades, a DNA-based test for cardiovascular disease seemed to work for Europeans and others but not Africans. Gladstone scientists just discovered why, with implications for many other diseases.
gladstone.org
The most common form of AI used in biomedical research falls within a category called machine learning.
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor @science.org @gladstoneinst.bsky.social @benoitbruneau.bsky.social www.science.org/doi/10.1126/...
Gladstone researchers found losing just one copy a particular gene can disrupt heart development and lead to congenital heart disease. @benoitbruneau.bsky.social @science.org @ucsfanesthesia.bsky.social @ucsanfrancisco.bsky.social
Misfolded DNA Blueprint: A New Origin for Genetic Disease
Gladstone researchers found losing just one copy a particular gene can disrupt heart development and lead to congenital heart disease.
gladstone.org
4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...
Contents | Science 393, 6809
science.org
On #WorldBrainDay, we're celebrating discoveries that help us better understand the brain. Gladstone researchers developed a new way to map how the brain clears away waste. The study found this cleanup process is disrupted in inflammation and Alzheimer's, opening opportunities for future therapies.
Mapping How the Brain Takes Out Its Trash
Gladstone scientists developed a new tool to trace how the brain clears “waste,” uncovering surprising new biology about how it keeps itself healthy.
gladstone.org
What if AI could do more than analyze data—what if it could design and run scientific experiments? Join Gladstone's Steve Finkbeiner at @cwclub.bsky.social for a conversation about the AI-powered "thinking microscope" and how it's changing the future of biomedical research.
Giving Scientists Superpowers: How an AI-Powered “Thinking Microscope” Is Fast-Tracking Medical Breakthroughs
Gladstone’s Steven Finkbeiner shares how Gladstone’s AI-powered microscope is racing to cure neurodegenerative disease.
commonwealthclub.org
Check out this @afar.org spotlight interview with @nalinirrao.bsky.social, where she describes the potential impact of her Alzheimer's disease research. https://bit.ly/4ytjm56
Nalini Rao, PhD - American Federation for Aging Research
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New research from the Jain Lab shows low oxygen can help alleviate disease caused by defects in a mitochondrial quality control machinery.
Discovery Spotlight│Controlling Oxygen to Fight Disease
YouTube video by Gladstone Institutes
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The #BrainBodySeminarSeries is excited to welcome @gladstoneinst.bsky.social's Dr. Andrew Yang. Join hosts @cameronmcalpine.bsky.social & @jmcastell.bsky.social when Dr. Yang presents "Tracing proteomes & immune cells across the #BloodBrainBarrier". Register 👉 mountsinai.zoom.us/webinar/regi...
We're gearing up for the 2026 Bay Are Heart Walk! Learn how you can support our team ➡️ https://bit.ly/3TnlUS9
