Could a brief speech sample support primary progressive aphasia (PPA) diagnosis? Researchers at the UCSF Fein Memory and Aging Center found that automated analysis of a 1-2 minute picture description accurately distinguished PPA variants and aligned with known brain and pathology patterns.

In #PrimaryProgressiveAphasia, automated #SpeechAnalysis of a brief picture description task distinguished nonfluent, logopenic, and semantic variants and produced interpretable speech profiles. ja.ma/4w4A2xg

Our new paper in @jamaneurology.com shows that automated analysis of just 1–2 minutes of speech can accurately distinguish primary progressive aphasia variants and reflects their underlying anatomy & pathology, with potential as a practical, interpretable tool to aid diagnosis and disease monitoring

Our new paper in Alzheimer’s & Dementia, led by Dr. Grebe, shows that higher education/occupation (cognitive reserve proxies) first support better semantic function in svPPA despite more brain atrophy, but then faster decline as reserve depletes: alz-journals.onlinelibrary.wiley.com/doi/epdf/10....

Our new paper in Cerebral Circulation – Cognition and Behaviour, led by Sanne Kuipers & Malin Overmars, applies Natural Language Processing to >1k memory clinic letters to study sex differences in documented cognitive features. Read here: www.sciencedirect.com/science/arti...

It's a wrap! Closing editorial with @briellestark.bsky.social and @andreaeyleen.bsky.social is out for our special issue of Cortex on Discourse Processing in the Brain. Turned out great. Learned a TON. Thanks contributors! www.sciencedirect.com/science/arti...

Closing editorial for the special issue of cortex: Neurocognitive perspectives on discourse and connected language

Language neuroscience has historically relied on highly controlled experimental paradigms that differ markedly from the conditions of real-world commu…

sciencedirect.com

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: New paper in Experimental Gerontology extends principal stratification to estimate the Survivor Average Causal Effect to model heterogeneity in treatment response in gerontologic trials. doi.org/10.1016/j.ex...

Causal Inference with Imperfect Data: Trial Emulation and Transportability Methods to Inform Dementia Prevention and Treatment Elizabeth Rose Mayeda, PhD UCLA UCSF Fein Memory and Aging Center Grand Rounds Monday, March 2, 10–11 a.m. PT register 👉

Edward and Pearl Fein Memory and Aging Center Grand Rounds

Causal Inference with Imperfect Data: Trial Emulation and Transportability Methods to Inform Dementia Prevention and Treatment Elizabeth Rose Mayeda, PhD Associate Professor of Epidemiology UCLA…

bit.ly

On behalf of @istaart.bsky.social #DaDA PIA: Join in San José at AAIC Neuroscience Next! 🧠 Feb 26, 2026 — Aging Research: Intro to Longitudinal Data Analysis Hands-on workshop with Dr. Ana W. Capuano on modeling change in cognition & function over time using real data. Registration now open!

Our new paper in Alzheimer’s & Dementia shows that automated item-level fluency features improve classification of semantic vs logopenic PPA. They outperform total scores & align with brain atrophy patterns—supporting scalable disease monitoring. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

On behalf of @istaart.bsky.social #DaDA PIA: Postdoctoral Associate opening in Pragmatic Dyadic Design. Seeking candidates with a PhD in biostatistics/quantitative methods, strong programming skills, and interest in pragmatic trials and AD/ADRD care. Apply here: postdocs.yale.edu/posts/2025-1...

On behalf of @istaart.bsky.social Design and Data Analytics #DaDA PIA: Are you interested in open science in #dementia research? Take the WYLDementia survey on data sharing in dementia research! Only 10 minutes, your insights can help shape more open & equitable science. forms.gle/GVuWAeHGmjaq...

Data Sharing Practices Survey

Thank you for taking the time to participate in this survey. The purpose of this survey, led by World Young Leaders of Dementia (WYLD Network) is to better understand data-sharing practices, percept...

forms.gle

Excited to share the launch of our new @istaart.bsky.social Cognition PIA SIG: Speech and Language Measures in Alzheimer’s Disease and Related Disorders, co-chaired with Alexandra König. Join our 1st meeting Jan 22, 2026 12:35pm CT (open to ISTAART members) Register: forms.monday.com/forms/9fd36c...

Don’t miss our free @istaart.bsky.social #DaDA PIA Year in Review webinar on Measurement Invariance & Harmonization across Cohorts, Jan 13 11:30am CT! Hear from speaker Dr. Sneha Mani & panelists Drs. Natalia Gomes Goncalves & Lars Lau Raket, moderated by yours truly. Register: alz.org/YearInReview

On behalf of @istaart.bsky.social Design and Data Analytics #DaDA PIA: New paper by Newsom et al. in Journal of Aging and Health explores how social support and strain predict multimorbidity trajectories. Support was linked to lower morbidity accumulation: journals.sagepub.com/doi/full/10....

On behalf of the @istaart.bsky.social Design and Data Analytics #DaDA PIA: 📣 An exciting full-time opportunity as a Postdoctoral Associate in Gerontologic Biostatistics at the Yale School of Medicine. Apply here: postdocs.yale.edu/posts/2025-1...

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: New paper by Nagel et al. in PLOS ONE uses sequence and cluster analysis to reveal distinct patterns of cardiometabolic disease accumulation and their link to later #dementia onset. Read more: doi.org/10.1371/jour...

Longitudinal sequencing of cardiometabolic multimorbidity among older adults and association with subsequent dementia onset

Background Patterns of development of cardiometabolic multimorbidity (CMM) and the impact of specific cardiometabolic disease combinations on cognitive function are not well understood. This study uti...

doi.org

On behalf of @istaart.bsky.social Design and Data Analytics PIA: We’ve compiled a new Resource Page on the ISTAART website highlighting key websites and tools shared during our #DaDA PIA Day at #AAIC2025. Check it out (PIA members only): urldefense.com/v3/__https:/... (File Categories>Resources)

On behalf of @istaart.bsky.social Design and Data Analytics PIA: New paper by Davis-Plourde et al. in Statistics in Medicine presenting 3 mixed model approaches for incorporating baseline outcomes in stepped wedge CRTs—valuable for trial design methodology. onlinelibrary.wiley.com/doi/10.1002/...

Designing Stepped Wedge Cluster Randomized Trials With a Baseline Measurement of the Outcome

Stepped wedge cluster randomized trials (SW-CRTs) are a type of uni-directional crossover designs and are increasingly common in prevention and implementation research. Although sample size formulas ...

onlinelibrary.wiley.com

📣 Help shape our @istaart.bsky.social DaDA 2026 Year in Review webinar w/Dr. Sneha Mani on Measurement Invariance and Harmonization across Cohorts! What were standout papers, methods, or insights in 2025? What’s next in 2026? 📚 Suggest papers+trends: alz.surveymonkey.com/r/FSG8RXX ⏳ Deadline: Dec5

On behalf of the @istaart.bsky.social Design and Data Analytics #DaDA PIA: New work by Dr. Lars Lau Raket et al. in Brain maps time course of #Alzheimer’s disease biomarkers—showing journey from #amyloid β positivity to severe #dementia spans up to 25 years. Open access: doi.org/10.1093/brai...

Estimating the time course of biomarker changes in Alzheimer’s disease

Raket et al. study the time course of biomarker changes in Alzheimer's disease, from the earliest detectable changes—often appearing a decade prior to symp

doi.org

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: Join for Webinar 3 in the ARISE 2025 series on Wed Oct 29, 12–1 PM CT! 🎓 Featuring early-career researchers at the intersection of aging, statistics, and data science Free and open to all – no registration required

Proud to share that I’ve received the official Notice of Award for my R01 from NIH National Institute on Aging: a 5yr $4.6M project to develop and validate speech-based tools for early Alzheimer’s detection. Grateful for my collaborators and the support—and spread the word: I’m hiring a postdoc!

Our new paper in Movement Disorders, led by Franco Ferrante, shows that digital fluency metrics from can predict and classify cognitive phenotypes in Parkinson’s disease, enabling scalable neuropsychological screenings. Read here: movementdisorders.onlinelibrary.wiley.com/doi/full/10....

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: We’re proud of our achievements and vibrant membership over the past year—and excited to keep building momentum in the year ahead!

On behalf of the @istaart.bsky.social Team: Join this week for one of two ISTAART All-Member Town Halls! 🌍 Learn about PIAs, meet leadership, and explore ways to get involved. 📅 Aug 26, 5–6 PM CDT 📅 Aug 27, 9–10 AM CDT 🔗 istaart.alz.org/home #ISTAART #AAIC

On behalf of the @istaart.bsky.social Design and Data Analytics PIA: 🚨 Aug 27 = ARISE 2025 launch! 🚨 Join for cutting-edge work by early-career scientists in aging + data science—no registration needed. 🧠 Genetics, changepoints, missingness in EHRs. 📍 Free & open to all! #ARISE #AgingResearch

Our @istaart.bsky.social Design and Data Analytics #DaDA PIA committee and friends got together on Monday night at Toronto Island and had a blast! #AAIC25

Tomorrow (Tue) morning at #AAIC25: join us for a fantastic session on Speech and Language Methods for Detecting and Tracking Cognitive Decline 🧠🗣️ 📍 Room 107, North Building (Level 100) 🕘 9:00–10:30 AM 📅 Tuesday, July 29 🚶‍♀️ 8 min from Exhibit Hall Don’t miss it!

Happening now! #DaDA PIA session on design and analysis of non-pharmacological interventions in room Harbor C at #AAIC25 ; it's not too late to sneak in and take a seat!