Check out our new paper in @lancetmicrobe.bsky.social In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB They perform consistently across settings + show potential clinical utility to stratify therapy #IDsky #TBsky bit.ly/47jU7GN

Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis

Single-gene transcripts are equivalent to multi-gene signatures for detection of subclinical tuberculosis, with consistent performance across settings. Single-gene transcripts show potential clinical ...

bit.ly

Check out our new paper in @lancetmicrobe.bsky.social In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB They perform consistently across settings + show potential clinical utility to stratify therapy #IDsky #TBsky bit.ly/47jU7GN

Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis

Single-gene transcripts are equivalent to multi-gene signatures for detection of subclinical tuberculosis, with consistent performance across settings. Single-gene transcripts show potential clinical ...

bit.ly

Optimising the use of currently available treatments through treatment stratification could reduce treatment duration by 2-months for the majority. TB treatment stratification strategies should be prospectively trialled in a phase III RCT. #TBSky

We’re hiring! Looking for a laboratory post-doc fellow to help us disentangle protective and pathogenic T cells in TB, so we can stratify disease-risk after infection, and develop more effective vaccines. Interdisciplinary science in the heart of London. What's not to like? More here: bit.ly/4iIEiwu

New preprint (with all pre-print caveats!) tinyurl.com/589ffhu4 on Mtb infection risk by sex & age. Men are at higher risk of #tuberculosis v women- but unclear how much driven by higher infection vs progression to disease. We meta-analysed Mtb immunoreactivity surveys to find out more🧵 #tbsky

“…despite the recent introduction of BPaL/M, resistance to these new antituberculosis drugs has already developed in at least 27 countries across four continents. Furthermore, a quarter of these cases involved patient-to-patient transmission” Worrying stuff

Gabriele Pollara@gpollara.bsky.social · 2y ago

⚠️ Bit of an alarm bell to MDR-TB regimen BPaL/M - resistance to constituent antibiotics developing and transmission of such strains already occurring #TBSky #IDSky @nejm.org www.nejm.org/doi/10.1056/...

Interested in the immunopathology of human tuberculosis? Here is our latest review: www.science.org/doi/10.1126/...

Immunopathology in human tuberculosis

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

science.org

🆕️⚡️⚡️Selected TB blood RNA signatures& CRP do not provide biomarkers of microbiological clearance to support TB treatment cessation at 8 weeks CRP achieved marginal albeit statistically significant discrimination/AUROC 0.69(95%CI 0.52–0.87) #idsky #medsky #tbsky publications.ersnet.org/content/erj/...

First wave ISGs (eg MX1) induced rapidly, correlate with VL & infectivity - potential biomarker to stratify patients who'll benefit from antivirals?

Check out our paper on RNA biomarkers in COVID-19 MX1 expression occurred early in infection before PCR detection…potential role to stratify treatment #IDSky

Mahdad Noursadeghi@mnoursad.bsky.social · 2y ago

Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...

Historical evidence that mass CXR screening is feasible and effective Very cool study - lots to be learnt from the past… #TBSky

Peter MacPherson@petermacp.bsky.social · 2y ago

DYK in 1957, Glasgow, Scotland ran the largest ever screening campaign against #tuberculosis? 715,000 people (76% of entire adult population) were X-rayed over just 5 weeks! In a new study, we looked at the long-term impact of this campaign. journals.plos.org/plosmedicine... #episky #idsky 🧪🛟

#UnionConf2024 has wrapped up, and what a conference! Some fascinating talks and great discussions. Seems to me that there are more questions than answers right now in #TBSky but its an exciting time.. Some personal highlights (in no particular order): 1/10