New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson! www.biorxiv.org/content/10.1...

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation

Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

biorxiv.org

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...

biorxiv.org

New PI life: competing with the “big labs” for rotation students feels like bringing a salad to a pizza party. 🍕🥗 No takers this round, but we’ll keep cooking 💪— the right students will come🫵

The Jiang Lab are having a great time at #ASBMB25 in Chicago!

The Jiang lab@Moffitt is attending @ASBMB! If you are interested in redox biology and cancer metabolism, check out our posters as listed below on Monday, April 14th, 2025! See you in Chicago! We are hiring now!