Another successfully published manuscript from Dr. Philippa Burns! Check out her work regarding the effects of serine starvation on RNA splicing 👀 aacrjournals.org/cancerres/ar...

Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?

Nature Metabolism@natmetabolism.nature.com · 4mo ago

Hot meeting alert!! 🚨🚨 @vai.org is hosting Rising Stars and Horizons in Metabolism, a new format, 2 day symposium highlighting both established and up and coming leaders in Metabolic research. Check it out and register here: www.vai.org/event/rising...

Rising Stars in Metabolism Symposium

Join us for Rising Stars in Metabolism Symposium at Van Andel Institute Stay informed about exciting upcoming events and activities.

vai.org

Very helpful methods and protocol! www.sciexplor.com/articles/fos... Great work @ginadenicola.bsky.social and team!

Excited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: www.sablesys.com/metphys-the-...

Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,

"What the state attorney general, what the city of Chicago has done in lots of ways has been remarkable in standing up for people" Futterman said. "But one of the ways in which they've fallen short so far, one of the tools they haven't used that they have, is actually the power to arrest people."

Another attorney representing the plaintiffs in the case, Craig Futterman with the UChicago law school, called on state and local officials to do more to hold federal agents legally accountable for their actions.

Tumor-draining Lymph nodes - Online event next week! follow the link to register On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer: events.cancer.gov/dcb/tdln #TLDNForums

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.

Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

nature.com

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: www.sciencedirect.com/science/arti...

Defined media reveal the essential role of lipid scavenging in supporting cancer cell proliferation

Fetal bovine serum (FBS) is an undefined additive that is ubiquitous to mammalian cell culture media and whose functional contributions to promoting c…

sciencedirect.com

Lucas Sullivan@lucasbsullivan.bsky.social · last yr.

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.

Repost! Please apply by October 15th for full consideration.

Katsu Funai@katsufunai.bsky.social · last yr.

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

A microneedle device for rapid dermal interstitial fluid sampling @stanforduniversity.bsky.social 🇺🇲 www.science.org/doi/10.1126/...

A microneedle device for rapid dermal interstitial fluid sampling

A device collects enough skin interstitial fluid for omics studies in just five minutes.

science.org

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...

biorxiv.org

An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells www.nature.com/articles/s42...

An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells - Nature Metabolism

Kaluba, Rogers et al. show that in cancer cells that can metabolize ketones, they may reroute them to produce cytosolic acetyl-CoA and support tumour growth.

nature.com

I am thrilled to share that I have received an ERC Starting Grant for our project SpaceMet! I am grateful for the ERC’s commitment to ambitious early-stage research and to KU Leuven for their support! Stay tuned, new postdoc positions coming soon!I @erc.europa.eu @kuleuvenuniversity.bsky.social

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

Prospects for ferroptosis therapies in cancer

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

rdcu.be

Harvard Molecular Metabolism@met-hsph.bsky.social · 12mo ago

Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out rdcu.be/eBbqV

🚨Preprint alert 🚨 We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants. www.biorxiv.org/content/10.1.... pls check @olzmannlab.bsky.social www.biorxiv.org/content/10.1... #ferroptosis #FSP1 #antioxidants

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

biorxiv.org

Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo... @abcamofficial.bsky.social

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355

The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...

jobs.sciencecareers.org

Fantastic meeting 🤩🤩 thank you @olzmannlab.bsky.social and Scott Dixon for the organisation and for all the colleagues and trainees that showed up and made ut such a great event! #ferroptosis #faseb #Ros

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy https://www.biorxiv.org/content/10.1101/2025.07.13.664609v1

1/ If you are in the Midwest and ❤️ metabolism, take note! This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference. www.vai.org/event/2025-m...

2025 Midwest Metabolism Meeting

Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

vai.org

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social jci.org/articles/vie... 1/6

Congrats to Dr. patrickjonker.bsky.social for successfully defending his thesis!

I'm excited to share the final version of some fun work from our lab. A few interesting phenotypes - depleting host glutathione causes intracellular Rickettsia to form long chains and get restricted by antibacterial autophagy. Congrats to the team! urldefense.com/v3/__https:/...

Host glutathione is required for Rickettsia parkeri cell division and intracellular survival

Nature Communications - Rickettsia species are bacterial pathogens that obligately reside in the host cell cytosol. Here, Sun et al. report that Rickettsia use host glutathione as a nutrient source...

urldefense.com

It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉