Delighted to share this new article where we propose our view for the next generation of human genetics. We argue a need for "Trait Causal Models" linking genetics to effects at all levels of biological structures, and talk about how to get there using gwas, perturbations and observational omics

Jeff Spence@jeffspence.github.io · 2d ago

It's been 30 years (!!!) since the conceptualization of GWAS. GWAS has driven tons of discoveries, but with recent experimental developments (CRISPR, single-cell omics), we thought it was time to think about how to drive the next 30 years of human genetics. doi.org/10.5281/zeno...

Is that good?

FinTwitter@fintwitter.bsky.social · 5d ago

Saudi Aramco HQ Hit in Suspected Houthi Strike, According to FT

Or more correctly: After four weeks of using the cream, participants changed the cellular composition of their skin

WIRED@wired.com · 7d ago

After four weeks of using the cream, participants lowered the biological age of their skin by about two years on average.

“We determined that the best way forward was a clean start with total rebranding, and in the 90 minutes of its existence, the new Tompkins University has had an absolutely pristine record when it comes to handling sexual misconduct.” — Michael Kotlikoff, university president

Cornell Tries Going By Different Name

ITHACA, NY—In an aggressive attempt to distance itself from an alleged sexual assault at one of its fraternity houses, Cornell University hastily announced Thursday that it was now going by a differen...

theonion.com

Grant review tip: 1) Read two grants 2) Rank them 3) Read the next grant 4) Rank them all 5) Repeat steps 3-5 until done Then you just score and critique according to their order in your distribution. Helps you to remember to use the full spectrum of scores too!

I’m looking for investors if anyone wants to try that Theranos idea again. You could probably pull it off profiling plasma proteins and leukocyte methylation

Finally learning that invited presentations are not only for talking about you own research, but also proselytizing and indoctrinating against academic foes

I get that AI in academia/research is a little controversial, but personally, it has greatly improved my ability to produce low-impact science.

I'd never be a journal editor because I am not a jerk.

Reposting this postdoc opening in our lab. We also now have an opening for a graduate research assistant for the same project. Deadline 23rd October 2026 and details here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Duncan Sproul@sproullab.bsky.social · last mo.

🚨 #Postdoc position open. Want to understand non-canonical #epigenetic regulation of mammalian transcription? Come work @uoe-igc.bsky.social in Edinburgh! We’re looking for a motivated & collaborative colleague with a strong track record. 📅 14 October 2026 📢 Please share Apply here 👇

Will cancer screening/detection ever be entirely biomarker based? I can't really imagine any biomarker tests that don't ultimately run through some 'imaging' framework. Imagine getting a positive biomarker result but there's nothing to see. Would you personally believe the positive test?

Groaning as I right click "GrimAge" in Microsoft Word and press "Add to Dictionary"

Watching the girls all night so @drcatherineb.bsky.social can watch her Super Bowl, the Patrick Clancy interview

Talking shit in my Duolingo-learned languages on chess.com

Perhaps the "drag" in NIH innovation over the last two decades (debatable) was just caused by the R01 budget cap. And now that it is uncapped, we'll be seeing more impressive discoveries

This is largely how I navigate life

👻 🎃 🦇 Boola Lughosti's Dad 🏳️‍⚧️ 🇵🇸@belalugosisdad.bsky.social · last mo.

Macklemore is a real case study in how you can be Kind of a Dumb Guy but still end up broadly on the right side of most things merely by being generally quite good-natured, because questions like "should trans people exist?" and "is it bad to do a genocide?" are actually really uncomplicated.

Breaking News: The former Kosovo leader Hashim Thaci was sentenced to 25 years in prison in a war crimes case that divided the country.

Kosovo’s Former Leader Is Sentenced to 25 Years in War Crimes Case

A tribunal in The Hague found Hashim Thaci, who led Kosovo’s independence struggle in the 1990s, responsible for arbitrary detention, torture and murder.

nyti.ms

Universal free school breakfast and lunch is a great proposal. www.thebulwark.com/p/exclusive-...

EXCLUSIVE: The Next Big Dem Proposal: Let Kids Eat Free

School lunches were free to all kids during the pandemic; a prominent think-tank wants to bring back the idea and make it permanent.

thebulwark.com

I don’t think you’re going to win anyone over by calling Ms. Rachel a bitch

Turns out the Irish tend to be pretty sensitive to genocide. Makes sense.

A thoughtful piece about the nuances of biological age assays. Biological real, but its still the Wild West, so come prepared. And if you want to save a couple hundred bucks, send me $20 and a picture and I'll tell you your biological age. It'll be about as accurate and reproducible as the clocks.

What Is Your Biological Age? What Aging Tests Really Tell You About How Your Body Is Aging

Think you’re younger than your age? Here’s what biological age tests can really tell you.

miamiherald.com

I love it when bioinformatics guys lead papers because they say things like “we do it because we can” even if it doesn’t make sense. Completely uninhibited from context. Truly an imaginative bunch

Whoaaaa boy what a finish!!!! USF with the amazing comeback win over Army. The Hartline era has officially begun!

This is what you get handed when you bum one on your break from line cooking

assbutt@nasboat.org · 6mo ago

back in the late 80s/early 90s, Camel started offering these hilariously oversized cigarettes. and as an added bonus, going back to a regular cigarette would make you feel like Andre The Giant holding a toothpick.

Probability of Necessity www.medrxiv.org/content/10.6... among people who had the variant and developed the disease, the probability that the disease would not have occurred if the didn't have the variant. Low penetrance variants can have a high PN.

Learning that you're an exception to a rule is a pretty damaging because then you think it applies more broadly.

Thanks to @jkresovich.bsky.social for hosting me at @moffittnews.bsky.social, where I got to chat with colleagues about how we study ‘epigenetics’ in human diseases. Everything from cellular reprogramming to cell fate to functional non-coding variants. Jake looks ready to meet the challenges!

Very strange for a bunch of people who profess to believe this AND who profess to be large-numbers extreme-case ultra-utilitarian philosophers not to be embracing the obvious and necessary solution

Carl Quintanilla@carlquintanilla.bsky.social · last mo.

ANTHROPIC EXEC: “.. I personally think it is >10% within the next decade.”

DOUBLED www.propublica.org/article/ecto...

Ectopic Pregnancy Deaths Have Nearly Doubled. It’s Worse in States With Abortion Bans.

With prompt and appropriate medical care, experts say, people shouldn’t die from an ectopic pregnancy. Women in Texas and Oklahoma have sued over delays in care, which, coupled with our new analysis, ...

propublica.org