Journal of Leukocyte Biology
@jlbjournal.bsky.social
đź”— https://academic.oup.com/jleukbio Since 1964, JLB has published first-rate research on immunology-related topics, with emphasis on leukocyte physiology and behavior within the immune system.
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Onn Thein and colleagues @unibirmingham.bsky.social report that #Neutrophil responses are significantly different in patients infected with different #COVID-19 variants
Dysfunctional neutrophil response in COVID-19 infection varies by subtype
Neutrophils isolated from patients with different COVID-19 subtypes showed improved function when infection occurred with newer variants.
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Do you have a manuscript that explores how abnormal #Leukocyte function contributes to the development of #Respiratory, #Infectious, and/or #Immune disorders in #Children? If so, our Targeted Science Collection is for you! 🚨 DEADLINE: NOV 19, 2026 🚨
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Emilija PaberalÄ— and colleagues report that monocyte-derived #DendriticCells exhibit a robust and broadly conserved early activation program across immune phenotype-specific #OvarianCancer lysate stimulation conditions
Monocyte-derived dendritic cell activation is broadly conserved across immune phenotype-specific ovarian tumor lysate pools, with donor-associated variation in response magnitude
Monocyte-derived dendritic cell activation was largely conserved across immune phenotype-specific ovarian tumor lysate pools, while response magnitude show
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Jia Hong & Su Shao identify a #SOX2-#TSTA3 axis involved in suppressing CD8+ #Tcell mediated antitumor immune responses in #BreastCancer by promoting #Fucosylation of #PDL1
SOX2/TSTA3 suppresses CD8+ T-cell-mediated immune response in breast cancer by regulating programmed death ligand-1 fucosylation
In breast cancer cells, SOX2 transcriptionally activates TSTA3 expression. Elevated TSTA3 enhances programmed death ligand-1 fucosylation, which increases
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S. Erandika Senevirathne and colleagues @tfreedmanlab.bsky.social @cfi-umn.bsky.social report that expression of #LynA and #LynB determines the extent of basal and induced phosphorylation of the activating kinase #Syk and the inhibitory phosphatase #SHIP1
Cumulative expression of the two Lyn isoforms creates a threshold for macrophage signaling in the absence of receptor engagement
Total steady-state expression of LynA and LynB determines the extent of basal and induced phosphorylation of the activating kinase Syk and the inhibitory p
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Anthony Veltri, Amali Samarasinghe and colleagues @uwmadison.bsky.social @uthsc.bsky.social show that allergic #Asthma reshapes the transcriptional states and spatial organization of lung #Eosinophils during #Influenza A infection
Single-cell and spatial transcriptomics define eosinophil heterogeneity during influenza A virus–induced exacerbation of fungal allergic asthma in C57BL/6 mice
Allergic asthma reshapes the transcriptional states and spatial organization of lung eosinophils during influenza A virus infection.
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Lucia Malaguarnera proposes a multidimensional #Chitinase–#Microbiota axis integrating environmental chitin exposure, host and microbial chitinolytic activity, innate immune signaling, epithelial–microbial interactions, and tissue remodeling
The chitinase–microbiota axis: connecting innate immunity, microbial ecology, and mucosal homeostasis
This review proposes a multidimensional chitinase–microbiota axis integrating enzymatic chitin processing, nonenzymatic chitinase-like protein signaling, h
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Jennell Jennett, Meera Nair and colleagues report that THC reshapes #Helminth-induced type 2 #Inflammation by restraining inflammatory leukocyte responses and reprogramming lung #Eosinophils and #Macrophages
Δ9-Tetrahydrocannabinol exposure shifts eosinophil and macrophage transcriptional programs toward an anti-inflammatory phenotype in helminth infection
THC reshapes helminth-induced type 2 inflammation by restraining inflammatory leukocyte responses and reprogramming lung eosinophils and macrophages.
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Telma Martins and colleagues review the involvement of low-density #Neutrophils in #BreastCancer and #LungCancer
Decoding low-density neutrophils in breast and lung cancer: from bystanders to drivers
Low-density neutrophils are a heterogeneous circulating neutrophil population that expands in breast and lung cancer and has been associated with advanced
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Elizabeth Kovacs and team @cudeptsurg.bsky.social discuss how #Burn injury, #Alcohol exposure, and #Aging converge on #ImmuneDysregulation, #GutBarrier dysfunction, and #Microbiome imbalance to drive systemic inflammation, multiorgan injury, and poor outcomes
Intoxication, inflammaging, and injury: my journey through leukocyte biology
A conceptual overview is presented showing how burn injury, alcohol exposure, and aging converge on immune dysregulation, gut barrier dysfunction, and micr
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Join us for our next FREE for all webinar! On Wed 10/28 at 1PM ET, Dr. Manjari Trivedi from Yale School of Medicine will present “Macrophages provide essential cues for liver regeneration”. This session will NOT be recorded so make sure you register here: www.leukocytebiology.org/index.php?op...
Building Bridges in Leukocyte Biology Webinar Series
leukocytebiology.org
Alejandro Schcolnik-Cabrera @ualberta.bsky.social and Rommel ChacĂłn-Salinas #IPNENCB present a News & Views highlighting a recent @jem.org article reporting a #Nerve-#MastCell-#Macrophage circuit associated with tissue repair following sterile injury
The light side of mast cell degranulation: delivering macrophage repair through molecular condensates
Salm et al. identified a nerve-mast cell-macrophage circuit in which cytoneme-delivered mast cell condensates promote macrophage aggregation and tissue rep
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Sun-Hwa Kim and colleagues report a metabolite-mediated feedback circuit linking #Neutrophils, commensal #Bacteria, and #DendriticCells in the intestinal mucosa
Metabolite-mediated crosstalk between neutrophils, commensal bacteria, and dendritic cells is associated with intestinal immune responses
Neutrophil-derived lactate attracts commensal Escherichia coli, while commensal-derived short-chain fatty acids restrain neutrophil activation, revealing a
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An exciting start to our October 2026 issue with the first #JLB Historical Perspective Review - "Hazy mysteries and the major histocompatibility complex: a journey" by David Raulet @davidraulet.bsky.social @ucberkeleyofficial.bsky.social
Hazy mysteries and the major histocompatibility complex: a journey
Investigating principles of natural killer cell recognition, roles in cancer immunosurveillance, regulation of activity, and immunotherapeutic potential.
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Xi Wang, Sven Brandau and colleagues show that #Neutrophils and #Macrophages differentially shape CD8+ #Tcell activity in the head and neck squamous cell carcinoma (#HNSCC) tumor microenvironment
Tumor-associated neutrophils and macrophages differentially affect T-cell biology in the head and neck cancer tumor microenvironment
Neutrophils and macrophages differentially shape CD8+ T-cell activity in the head and neck squamous cell carcinoma tumor microenvironment, with neutrophils
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Carlos Blanco-Camarillo and colleagues report that #Obesity induces elevated numbers of low-density #Neutrophils (LDN), but these perform #Phagocytosis and #NETosis less efficiently than LDN from individuals with normal weight
Diminished FcÎłRIIa expression reduces antibody-mediated phagocytosis by low-density neutrophils in obesity
Obesity reduces phagocytosis by low-density neutrophils.
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Young Jun Kang shows that mitochondrial phosphatase #PGAM5 negatively regulates #IL4-induced anti-inflammatory responses and metabolic reprogramming of #Macrophages by controlling #JAK1-#STAT6 signaling
Mitochondrial phosphatase PGAM5 negatively regulates the induction of anti-inflammatory macrophages
Mitochondrial phosphatase PGAM5 negatively regulates IL-4-induced anti-inflammatory responses and metabolic reprogramming of macrophages by controlling JAK
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Nahuel Ko and colleagues propose that #TissueResidency should be incorporated into next-generation #Immunotherapy to achieve durable responses in #SolidTumors
From sentinels to soldiers: tissue-resident cells for next-generation immunotherapy
Tissue-resident inspired immunotherapy.
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@leukocytebiology.bsky.social and #JLB are pleased to announce the first JLB Impact Award, which celebrates and acknowledges the contributions of high-impact authors to the journal!
JLB Impact Award 2026
SLB and JLB are pleased to announce the first annual JLB Impact Awardees. Rupesh Srivastava and Asha Bhardwaj are recognized for their publication “Gut-resident regulatory T cells (GTregs) play a…
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Capucine Bourel and colleagues @umontreal.ca @umontreal-en.bsky.social report that #MHC I shapes mouse #NKcell functional maturation
Mouse NK cell functional maturation is dependent on MHC I
MHC I shapes mouse NK cell functional maturation stages independently of effector protein expression. In other words, the expression of effector proteins c
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Xiaoling Li and colleagues @loyolachicago.bsky.social show that #MyD88 deficiency protects against intestinal barrier damage after ethanol and #BurnInjury, and suppresses #Neutrophil extracellular trap formation
MyD88 promotes neutrophil extracellular trap formation and gut leakiness after ethanol and burn injury
MyD88 deficiency protects against intestinal barrier damage after ethanol and burn injury and suppresses neutrophil extracellular traps.
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Burcu Al and colleagues @unibonn.bsky.social report that loss of Kmt2c and Kmt2d histone methyltransferases in #Macrophages leads to impaired pro-inflammatory cytokine responses, reduced phagocytotic capacity and skewed energy metabolism toward glycolysis doi.org/10.1093/jleu...
Kmt2c and Kmt2d histone methyltransferase deficiencies compromise macrophage function
Loss of Kmt2c and Kmt2d histone methyltransferases in macrophages leads to impaired pro-inflammatory cytokine response and phagocytotic capacity, as well a
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Jiongming He, Shan Liu, Lingying Wang & Fei Xiong report that #EsophagealCancer cells impair #NKcell function via the downregulation of #ZNF600 expression through the ligation of #CEACAM1 with #TIM3
Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells
ZNF600 enhances the cytolytic activity of NK cells. EC cells downregulate ZNF600 expression in EC-associated NK cells via the ligation of CEACAM1 to TIM-3
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@brita-o.bsky.social and colleagues @gwibs.bsky.social show that platelet activation due to #HIV infection increases #Platelet-#NKcell complexes, which have distinct phenotypes and may alter the total NK cell population in people living with the virus
Circulating platelet-natural killer cell complexes are elevated in people living with human immunodeficiency virus on antiretroviral therapy
Platelet activation due to human immunodeficiency virus infection increases platelet-natural killer (NK) complexes, which have distinct phenotypes and may
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Gerardo Ortiz and colleagues @imii.cl review the the interplay between heat shock factor 1 (#HSF1) and heat shock proteins in the context of #Inflammation caused by infectious and non-infectious diseases
Beyond proteostasis: the HSF1–Hsp axis in inflammation
Abstract. Inflammation is a multifaceted response involving molecular and cellular components triggered by diverse stimuli, including physical, chemical, a
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Carlos Silvestre-Roig and colleagues @uni-muenster.de report that nuclear factor-Y (NF-Y) controls #Myeloid survival and inflammatory state during #VascularInflammation
The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease
NF-Y controls myeloid survival and inflammatory state during vascular inflammation.
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The September Issue of #JLB kicks off with a Review from Marlene Starr and colleagues @ukresearch.bsky.social that examines whether new approaches and methodologies can adequately replace animal models in #CriticalCareResearch
New approach methodologies complement but cannot replace animal models in critical care medicine research
New approach methodologies offer opportunity for methodological pluralism but cannot replace animal models due to their limitations in providing systemic o
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We are less than a week away from our conference!! What are you most excited about for #SLB2026? Answer in the replies below 👇
Essi Tchalla, @elsaawesomepmns.bsky.social and colleagues @ubuffalo.bsky.social present that #Neutrophils induce formation of protective #Antibodies in response to the #PneumococcalConjugateVaccine by controlling #RegulatoryTcell numbers
Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting T regulatory cells
Neutrophils induce formation of protective antibodies in response to the pneumococcal conjugate vaccine by controlling T regulatory cell numbers.Created in
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