Decades of immunity research and the latest developments at #ImmunoSRC, featuring keynote speaker @stefanfeske.bsky.social. Register and submit your abstract by May 17 for a short talk or poster session: buff.ly/DoUqsUx

New publication from the Freedman Lab: "Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse," led by PhD-student Erandika Senevirathne, is out now in JI. academic.oup.com/jimmunol/art... @cfi-umn.bsky.social 🧪

Congratulations to newly minted Dr. S. Erandika Senvirathe on a successful PhD defense! Next, she'll head to a postdoc in Dr. Durga Singer's group at Univ. of Michigan, Ann Arbor.

Join us Friday, Jan. 16, 2026, for Erandika Senevirathne's Final Ph.D. Defense: "Steady-state phosphorylation of SHIP1 by Lyn restricts macrophage activation in the absence of a phagocytic synapse." Advisor: Tanya Freedman(@tfreedmanlab.bsky.social), 9:00 am, 1-125 CCRB

New publication: "Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner" is out now in JLB. MD/PhD student Anders Lindstedt led with an assist from @lab-williams.bsky.social. academic.oup.com/jleukbio/art... @cfi-umn.bsky.social 🧪

Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner

RNA sequencing and functional assays demonstrate that both LynA and LynB restrict macrophage proliferation and drive TLR-induced ECM remodeling and inflamm

academic.oup.com

Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better. And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings: solvingfor.org/news-posts-d...

The Results are In: Preview The Discovery Stack Pilot Paper

Reimagining Peer Review: Feasibility and Value of a Scientist-Designed, Metric-Driven Model

solvingfor.org

Richard Sever@richardsever.bsky.social · 9mo ago

Always great to see peer review experiments with actual data. SolvingForScience distinguish Quality (Q) & Impact (I) scores for papers. Q scores are based on a peer-improvement phase, followed by an I assessment by a different group. Unsurprisingly I varies more than Q 1/2 doi.org/10.1101/2025...

Join us Friday, Oct 17th, 2025 for Anders Linstedt's MICaB Final Ph.D. Defense: "Lyn kinase controls Toll-like receptor signaling in a cell-specific, isoform-independent manner" Advisor: Tanya Freedman(@tfreedmanlab.bsky.social), 9:00 am, 1-110 LRB/MTRF or Zoom info at immunology.umn.edu

Congratulations to Freedman-lab PhD Student Erandika Senevirathne for winning an Oral Presentation Award at the FASEB Meeting "Signal Transduction in the Immune System!" Congrats also to the other awardees. The level of trainee engagement at this meeting was phenomenal! Well done, all!

The early registration deadline for FASEB "Signal Transduction in the Immune System" is this Sunday, 6/8! Details: 6/28-7/2 Keynote by the amazing Anjana Rao A great lineup of speakers, posters, and workshops A much-needed opportunity to gather and share ideas events.faseb.org/event/27cba3...

Just said goodbye to my NIH MIRA award. Really hurts to see the word “terminated” in writing. Even worse to see it next to the F31 awarded to a fantastic PhD student in my lab @aybv.bsky.social. I REFUSE to let this stop us!!!

Preprint alert from the Freedman lab! PhD student Erandika Senevirathne reveals a unique role for the Src-family kinase Lyn in maintaining steady-state signaling in macrophages and a role for the phagocytic synapse in protecting against negative feedback by SHIP1. 🧪 www.biorxiv.org/content/10.1...

Steady-state phosphorylation of SHIP1 by Lyn restricts macrophage activation in the absence of a phagocytic synapse

Microscale engagement of the hemi-ITAM-containing receptor Dectin-1 by a fungus-derived particle initiates signaling through the Src-family kinases (SFKs) and Syk that leads to downstream Erk and Akt ...

biorxiv.org

We have a fantastic agenda planned for the 6/2025 FASEB meeting "Signal Transduction in the Immune System." Top-notch science, career/policy sessions, flash talks, and lively discussion. Message me for info on registration awards. Learn more and register now: events.faseb.org/event/Signal... 🧪

The NIH eRA Commons website has been down all afternoon. Does anyone have insight on whether this is a glitch or a plan? 🧪

I ❤️ UW Immunology. Thank you @jmoltke.bsky.social. komonews.com/news/local/t...

Seattle scientists protest Trump's medical funding freeze, warn of research impacts

Biomedical research is teetering on a crisis after President Donald Trump held up the grant money that helps fund the industry, pending a review of all federal

komonews.com

I think people both within science and outside science don’t fully appreciate the miracle that were the Covid-19 vaccines. How much courage it took to get the sequence out, how much work had already gone into figuring out the best viral antigen and how best to present it. 1/

Patrick Mitchell (@psmitchej.bsky.social), Thornton Thompson and I wrote an OpEd, with support from 650+ biomedical researchers across Washington State (450+ at time of submission). www.heraldnet.com/opinion/comm... List: www.moltkelab.com/s/NIH-OpEd-S...

Comment: Pending cuts to medical research would harm all in state | HeraldNet.com

As UW medical scientists, we urge Washingtonians to defend the NIH’s life-saving research funding.

heraldnet.com

Information hygiene request - please circulate & take action. I’m getting bombarded with frantic fragments. Information flow is crucial right now, and every link in the chain matters. This is a concrete place where you can play a massive role in improving transmission. Start with SIFT method:

We're hiring! Funded postdoctoral position available in the Moltke Lab. 79k starting salary and access to a fellowship program in the Institute for Translational Immunology that offers both academic and industry training tracks. Details here: jobrxiv.org/job/universi...

Postdoctoral Fellow - Moltke Lab

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

IT'S OFFICIAL! From today, @plos.org and its journals are no longer posting on Twitter/X. If you want to carry on hearing about great science in our journal, follow @plosbiology.org on Bluesky here: bsky.app/profile/plos...

Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase. Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...

Our work was recently featured in a Research Spotlight by the NIH Office of Research on Women's Health: orwh.od.nih.gov/in-the-spotl...

I'm here giving BlueSky a try. Can this community replicate the pre-x Twitter experience? I'm hoping the best parts of the scientific, artistic, philosophical, and political discussions will come together again. (Let x=Elon, pandemic, content-onslaught, etc. that caused me to delete the app.)