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Jogender Singh

@jogender-singh.bsky.social

Assistant Professor at IISER Mohali

22 Posts51 Follower25 Folgt
Jogender Singh@jogender-singh.bsky.social · 2mo ago

Happy to share our latest work by Annesha Ghosh, published in @genetics-gsa.bsky.social. Using genetic screens, we identify that the deubiquitinase USP-14 regulates innate immunity in C. elegans. academic.oup.com/genetics/adv...

Deubiquitinase USP-14 regulates intestinal distension-induced immunity via Wnt/β-catenin signaling in C. elegans

Abstract. Pathogen infections disrupt multiple host cellular processes, and hosts have consequently evolved mechanisms to detect these perturbations and in

academic.oup.com

Jogender Singh@jogender-singh.bsky.social · 3mo ago

Happy to share our latest study by Annesha Ghosh, published in PLOS Pathogens. Our work shows that disruption of RNA cap methylation can act as a danger signal to activate protective innate immunity. dx.plos.org/10.1371/jour...

RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response

Author summary The immune system is commonly thought to defend the body by recognizing invading microbes. However, organisms can also detect infections indirectly by sensing damage to their own cellul...

dx.plos.org

Alejandro Aballay, PhD@aaballay.bsky.social · 8mo ago

Our new work shows that live E. faecium reduces motor neuron degeneration and improves locomotion in a C. elegans ALS model. Protective effects depend on the induction of cytochrome P450 genes regulated by the intestinal nuclear hormone receptor NHR-86: journals.plos.org/plosbiology/...

A gut-activated NHR-86–CYP pathway mediates the neuroprotective effects of Enterococcus faecium probiotics in a nematode model of amyotrophic lateral sclerosis

Probiotics can influence neuronal health, but how microbial signals are translated into neuroprotective host responses remains poorly understood. This study shows that Enterococcus faecium activates a...

journals.plos.org

Jogender Singh@jogender-singh.bsky.social · 8mo ago

Happy to share our recent work published in #Genetics! Ravi previously showed that thiol reductive stress activates the hypoxia response (HIF-1) pathway. Now he shows that the HIF-1 pathway protects from thiol stress via an acyltransferase. @genetics-gsa.bsky.social academic.oup.com/genetics/adv...

Protection from thiol reductive stress through an autoinhibitory hypoxia response pathway in Caenorhabditis elegans

Abstract. Cellular redox homeostasis depends on a finely tuned balance between oxidizing and reducing conditions, and disturbances in this balance lead to

academic.oup.com

Jogender Singh@jogender-singh.bsky.social · 9mo ago

Happy to share our latest work by Shivani Gahlot and Subodh, published in @febsj.bsky.social. We show that the amino acid Trp is highly toxic to C. elegans, and that this toxicity is driven by bacterial metabolism of Trp into indole. febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

Bacterial metabolism of tryptophan causes toxicity in C. elegans. E. coli takes up tryptophan and catabolizes it to indole via tryptophanase (TnaA). Indole can freely diffuse through lipid membranes ...

febs.onlinelibrary.wiley.com

Jogender Singh@jogender-singh.bsky.social · 10mo ago

Happy to share another story by Annesha Ghosh. Here, we show that inhibition of the mRNA cap methyltransferase CMTR-1 activates a protective immune response via the GATA transcription factor ELT-2. www.biorxiv.org/content/10.6...

RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response

Organisms can activate innate immunity not only by detecting pathogens but also by sensing disturbances to essential cellular processes. Such damage-based surveillance provides a means to identify cel...

biorxiv.org

Jogender Singh@jogender-singh.bsky.social · 10mo ago

Pleased to share our latest work by Annesha Ghosh. Using genetic screens, we identify that the deubiquitinase USP-14 regulates innate immunity in C. elegans. www.biorxiv.org/content/10.1...

Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/β-catenin signaling

Pathogen infections disrupt multiple host cellular processes, and hosts have consequently evolved mechanisms to detect these perturbations and initiate appropriate immune responses. In Caenorhabditis ...

biorxiv.org

Jogender Singh@jogender-singh.bsky.social · 11mo ago

I’m thrilled to share that our latest work, led by PhD scholar Priyanka Das, is published in @embojournal.org! Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways | The EMBO Journal

imageimageGut microbes are key modulators of host lifespan, yet the underlying mechanisms remain poorly understood. This study shows that gut microbes, which induce oxidative stress in Caenorhabditis elegans, extend the host’s lifespan by ...

embopress.org

Jogender Singh@jogender-singh.bsky.social · last yr.

Pleased to share our latest work by Shivani and Subodh. We show that the essential amino acid Trp is highly toxic to C. elegans. It turns out that the bacterial diet is the culprit. Bacterial metabolism of Trp to indole causes the toxicity. www.biorxiv.org/content/10.1...

Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans

Tryptophan is an essential amino acid required not only for protein biosynthesis but also for the production of several physiologically important metabolites, including serotonin, kynurenine, and nico...

biorxiv.org

Surojit Sural@surojitsural.bsky.social · last yr.

Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling www.nature.com/articles/s41...

Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling - Nature Communications

The authors show that in C. elegans, Vitamin B12-driven changes in neuronal methionine cycle trigger a neuron-gut signalling axis, involving serotonin and neuropeptide secretion that modulate stress t...

nature.com

Javier Apfeld@javierapfeld.bsky.social · last yr.

Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans. Email or DM me to find out more. Please share & repost!

Postdoctoral Research Associate, Biology

About the Opportunity Job Summary The Apfeld Lab at Northeastern University is seeking a postdoctoral researcher to investigate how genes work together to determine the maximum lifespan of the nematod...

northeastern.wd1.myworkdayjobs.com

Javier Apfeld@javierapfeld.bsky.social · 2y ago

Worm people: We need YOU to help recruit more mentees for the C. elegans Community Mentor Match program! 🪱✨ 📢 Help us sign up more mentees by sharing this this slide with your lab in your next lab meeting!

Join the C. elegans Community Mentor Match Program!

Join the C. elegans Community Mentor Match Program! sign up for mentors sign up for mentees and to join peer-mentoring groups https://forms.gle/DpGTWRMrNGL96wHy8 https://forms.gle/pVBD5DYGXyLT4waLA

docs.google.com

Javier Apfeld@javierapfeld.bsky.social · 2y ago

Worm friends: The C. elegans Community Mentor Match Program is signing up mentees! Click on the link to be matched with a mentor and/or to join a peer-mentoring group. Please spread the word, and share with your lab members and worm friends! 📢 1/n

Mentee sign-up for the 2025 C. elegans Community Mentor Match program

The 2025 C. elegans Community Mentor Match is open to graduate students, postdocs, and faculty at any career stage. This survey collects information to help the committee (a) identify the most appropr...

forms.gle

Kavita Babu@kavita-babu.bsky.social · 2y ago

The first one is some crazy work by @monmitabhar.bsky.social, Tanumoy, @hari-flies.bsky.social and Kamal Kishore. They eavesdropped on worm conversations and found the exciting phenomenon of movement of memory from one worm to another 2/n www.biorxiv.org/content/10.1...

Extracellular vesicles aid in the transfer of long-term associative memory between Caenorhabditis elegans

Memory formation is necessary for the survival of animals across phyla. Here, we elucidate the mechanism underlying the formation of long-term associative memory (LTAM) formed by treating Caenorhabdit...

biorxiv.org

Jogender Singh@jogender-singh.bsky.social · 2y ago

Happy to share our latest work led by grad student Priyanka Das. Using a genome-wide bacterial screen, we identify that dietary iron limitation extends C. elegans lifespan via its oxidative stress response pathways. www.biorxiv.org/content/10.1...

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways

Gut microbes play a crucial role in modulating host lifespan. However, the microbial factors that influence host longevity and their mechanisms of action remain poorly understood. Using the expression...

biorxiv.org

Jogender Singh@jogender-singh.bsky.social · 2y ago

Happy to share a review by grad student Ravi on the complex crosstalk between redox homeostasis and hypoxia signaling in the FEBS Journal. We also discuss the future research prospects at this exciting interface. febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Redox homeostasis, the balance between oxidative and reductive processes, is essential for cellular function and organismal health. Disruption, either through excessive oxidants (oxidative stress) or...

febs.onlinelibrary.wiley.com