Lance Johnson
@johnsonlab.bsky.social
Studying brain metabolism, Alzheimer's Disease, glia & all things APOE at the University of Kentucky. opinions are my own (but I feel like they are quite good)
🚨Fresh pre-print collab with @johnsonlab.bsky.social, Norton Healthcare, and our @uksbcoa.bsky.social collaborators. We report a coordinated CD8+ Tcell immunometabolic program associated with amyloid-related imaging abnormalities (ARIA) during lecanemab therapy👇 🔗 www.medrxiv.org/content/10.1...
Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA
Amyloid related imaging abnormalities (ARIA) remain the principal safety concern limiting adoption of anti amyloid therapies such as lecanemab, yet their underlying biology is poorly defined. To addre...
medrxiv.org
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 11mo agoKnockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli https://www.biorxiv.org/content/10.1101/2025.09.02.673815v1
Are you an ATP!?! We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs). Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY. Apply here! rb.gy/3zk4cm
Shoutout to Sanders-Brown trainees as they met with legislators on Capitol Hill during the @alzassociation.bsky.social Advocacy Forum! medicine.uky.edu/news/kentuck... @ukresearch.bsky.social @universityofky.bsky.social @johnsonlab.bsky.social @bachstetterlab.bsky.social @mpmurphy.bsky.social
medicine.uky.edu
What does the APOE 'lipid droplet-ome' look like??? Check out our new paper to find out! www.sciencedirect.com/science/arti... Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social +help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses
Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…
sciencedirect.com
Kudos to 𝐒𝐭𝐞𝐯𝐞 𝐌𝐚𝐜𝐋𝐞𝐚𝐧, a T32 in the @johnsonlab.bsky.social who does outstanding work! medicine.uky.edu/centers/sbco... @ukresearch.bsky.social @universityofky.bsky.social #APOE
Student Spotlight: Steve MacLean
medicine.uky.edu
I cannot wait for @erinmgibson.bsky.social visit to Univeristy of Kentucky next week!!!! How lucky are we!!! 🤩🤩🤩
New pre-print out: www.biorxiv.org/content/10.1... Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social
High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease
Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and intracellular hyperphosphorylated tau pathology is associated with distinctive (and possibly disease-dr...
biorxiv.org
As NIH and university funding in the US is dismantled and as this admin revokes international student visas for no reason…we need to make a stand. Thanks @ardemp.bskyverified.social for being vocal about what’s at stake! www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
cnn.com
Congratulations to #APOE25 Award Winners Lesley Golden, Ph.D., and Aura Ramirez, Ph.D. on their work to advance dementia science. #AAICAdvancements
Our latest in PNAS! 🎉 ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep Take home message? KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions. www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...
pnas.org
Grateful to The Scientist for listening to my story and amplifying our concerns regarding bans on NIH communication and govt funding. www.the-scientist.com/freeze-on-ni...
Freeze on NIH Grant Reviews Leaves Scientists Confused and Frustrated
An unprecedented federal ban on scientific meetings halts research progress, sparking widespread concern across the scientific community.
the-scientist.com
new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
For my first post, an invitation to join us in Miami! A lot of thing on ApoE and lipids are moving fast, catch up! Abstract submission is now open!
@rikvanderkant.bsky.social @macauleylab.bsky.social hook it up, yo can't have @morganti.bsky.social gloating about how he has more followers than me