Joris Deelen
@jorisdeelen.bsky.social
Associate professor at the section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center working on the genetics of human longevity and biomarkers of healthy ageing #genetics #biomarkers #ageing
A generalized approach for estimating the pace of aging academic.oup.com/biomedgeront...
A generalized approach for estimating the pace of aging
AbstractBACKGROUND. Quantifying the rate of aging is essential for understanding age-related physiological decline and predicting late-life outcomes. The P
academic.oup.com
Happy to share our new methods paper in which we developed a mortality-informed weighted Pace of Aging based on longitudinal data from the Swedish Adoption/Twin Study of Aging! 🧪 academic.oup.com/biomedgeront...
A generalized approach for estimating the pace of aging
AbstractBACKGROUND. Quantifying the rate of aging is essential for understanding age-related physiological decline and predicting late-life outcomes. The P
academic.oup.com
Did you know that both DuSRA and @americanaging.bsky.social members are eligible to membership rates for BSRA’s Annual Scientific Meeting? The BSRA's 75th annual meeting looking like a great one! See you there DuSRA & AGE members! 9-11 Sept Oxford bsra.org.uk/events/75th-... #BSRA2026
75th Annual Scientific Meeting of the BSRA (2026): The Biology of Ageing - BSRA
BRITAIN’S LEADING AGEING RESEARCH CONFERENCE In 2026, the BSRA is pleased to host its 75th Annual Scientific Meeting on the Biology of Ageing at the University of Oxford between 9th and 11th September...
bsra.org.uk
I am very proud of @maraneuerburg.bsky.social with her excellent PhD defense today! Now up to the next adventure!
MPI for Biology of Ageing@mpiage.bsky.social · 4mo ago🎓 Big congrats to Mara Neuerburg @maraneuerburg.bsky.social from the lab of Joris Deelen @jorisdeelen.bsky.social for successfully defending her PhD thesis today. 🎉 Mara, we hope you’re as proud of yourself as we are. We wish you all the best for your next steps! 🫶
📣 Neue Podcast-Folge 📣 Prof. Dr. Joris Deelen erzählt, warum manche Menschen über 100 Jahre alt werden und was uns die Langlebigkeits-Gene APOE und FOXO3 über das Altern verraten. 🎧 Hier gehts zur Folge: codedeslebens.podigee.io/55-langlebig... #Genetik #Forschung #Podcast #Wissenschaft #GHGA
I am very happy to present you the latest preprint from my group at the @mpiage.bsky.social, which is the main outcome of the PhD project of Mara Neuerburg! 🧪🧬
bioRxivpreprint@biorxivpreprint.bsky.social · 5mo agoRare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species https://www.biorxiv.org/content/10.64898/2026.05.28.728260v1
🚨Excited to share our new medRxiv preprint spearheaded by Mengle Zhu in which we provide novel mechanistic insights into the biology of familial longevity and cardiometabolic resilience using metabolomic and proteomic profiling!🚨 @molepi.bsky.social 🧪 www.medrxiv.org/content/10.6...
Multi-omics integration identifies metabolic and inflammatory pathways underlying familial longevity
Familial longevity, quantified using the Longevity Relatives Count (LRC) score indicating the proportion of ancestral long-lived family members, associates with a pronounced 13 years delayed onset of ...
medrxiv.org
Human whole-blood NAD+ levels do not vary with age or lifestyle interventions www.nature.com/articles/s42...
Human whole-blood NAD+ levels do not vary with age or lifestyle interventions - Nature Metabolism
Whole-blood NAD+ levels are found to remain remarkably stable across age and lifestyle interventions in humans, challenging the use of blood NAD+ levels as a biomarker of ageing or lifestyle.
nature.com
I’m hiring! We have a position for a scientist in our department Neurobiology & Aging. Check out the vacancy in Dutch & English in the links below 🧠
Biomedical Primate Research Centre@bprc-eu.bsky.social · 6mo agoWe zoeken een onderzoeker Neurobiologie & Veroudering die wil bijdragen aan onderzoek met maatschappelijke impact op vraagstukken rond veroudering, infecties en het brein! Nederlands: www.bprc.nl/over-bprc/co... English: www.bprc.nl/en/about-bpr...
💥 New publication from the Demetriades and Nüchel groups– final version now online in EMBO reports! This Tour de force wouldn’t have worked out without the amazing support from our collaborators and core facilities!
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi - EMBO Reports
Lysosomes are multifunctional organelles that play important roles in cellular recycling, signaling, and homeostasis, relying on precise trafficking and activation of lysosomal enzymes. While the Golg...
link.springer.com
🚨 Scholarship Alert! 🚨 🧬👩🏽🔬 Pursue your Master studies in Biology or Biochemistry in Cologne at @unicologne.bsky.social and get full funding with our CGA Master Fellowship programme.💰 📅 Apply by July 15! 🔗 Learn more: www.ageing-grad-school.de/master/maste...
🚨I am happy to share our new paper in collaboration with @haggsara.bsky.social, spearheaded by Larissa Smulders 🚨 We provide further evidence that MetaboHealth is moderately heritable (40%) and is likely modifiable through lifestyle, e.g., smoking cessation. 🧪🚭 link.springer.com/article/10.1...
The MetaboHealth score is 40% heritable and is influenced by frailty status, BMI, and smoking in Swedish twins - GeroScience
The MetaboHealth score, a metabolomics-based biomarker trained on mortality, is associated with ageing-related phenotypes and morbidity, but its heritable component is still uncertain. Understanding g...
link.springer.com
🚨I am happy to share our new paper in collaboration with @haggsara.bsky.social, spearheaded by Larissa Smulders 🚨 We provide further evidence that MetaboHealth is moderately heritable (40%) and is likely modifiable through lifestyle, e.g., smoking cessation. 🧪🚭 link.springer.com/article/10.1...
The MetaboHealth score is 40% heritable and is influenced by frailty status, BMI, and smoking in Swedish twins - GeroScience
The MetaboHealth score, a metabolomics-based biomarker trained on mortality, is associated with ageing-related phenotypes and morbidity, but its heritable component is still uncertain. Understanding g...
link.springer.com
📣#CECAD will host two exciting conferences 📆 11th - 14th October 2026 15th AHA Conference - “From mechanisms of age-associated diseases to healthy aging” uni.koeln/7X2K8 📆 14th - 16th October 2026 1stEFAR Conference - “On the Biology of Aging” uni.koeln/YGPMA 👉 Submit abstracts by May 31st
Epidemiological approaches to refine biomarkers of aging www.nature.com/articles/s43...
Epidemiological approaches to refine biomarkers of aging - Nature Aging
Studies of biomarkers of aging encounter a range of epidemiological and methodological challenges, many of which are not fully acknowledged. In this Comment, we critically examine key challenges and s...
nature.com
Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk https://www.medrxiv.org/content/10.64898/2026.02.15.26346369v1
What started as a student project from Gabriela Natalle Lopes together with Niels vd Berg has now become a fleshed out preprint in which we present Personal-MetaboHealth, a personalised version of MetaboHealth based on clinically validated metabolic biomarkers. 🧪 www.medrxiv.org/content/10.6...
Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk
The biomarker MetaboHealth represents a novel indicator of overall health in middle age and may potentially be suitable as actionable health check in prevention strategies. MetaboHealth is a blood-bas...
medrxiv.org
🆕 @science.org Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors science.org/doi/10.1126/...
Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families www.biorxiv.org/content/10.6...
biorxiv.org
Ben je geïnteresseerd naar ons onderzoek naar gezonde veroudering binnen de sectie @molepi.bsky.social van de afdeling @bds-lumc.bsky.social bij het LUMC? Kijk dan naar dit item van het Belgische programma @terzake.bsky.social van @vrtnws.be waarvoor ik geïnterviewd ben. www.vrt.be/vrtnws/nl/ki...
"We leven langer, maar hoe kunnen we gezond langer leven?" Onderzoekers op zoek naar de sleutel | VRT NWS: nieuws
Altijd op de hoogte van het laatste nieuws uit binnen- en buitenland dankzij de betrouwbare en diepgaande berichtgeving van VRT NWS.
vrt.be
Wat is de ideale methode als je wil beginnen met vasten? Zo pakken deze experts het aan. Voor meer tips, luister naar aflevering 3 van Leef als een Naakte Molrat: Spotify: lnkd.in/eyGeyybx Apple Podcasts: lnkd.in/e_JwiYvh #fasting #vasten #gezondheid #afvallen #wetenschap
Was erg leuk om bij te dragen aan de @naaktemolratpod.bsky.social podcast serie over veroudering en vasten van Leon Doedens!
Leef als een naakte molrat@naaktemolratpod.bsky.social · 9mo agoIn deze podcastserie eet ik drie dagen lang niks. Maar waarom kan dat je biologische leeftijd verlagen? Experts Pol Grootswagers en @jorisdeelen.bsky.social leggen uit hoe dat zit.
🚨 Deadline Extended! 🙏 RT: Postdoc opening @ Babraham Institute, Cambridge to study extracellular #proteostasis and #aging. If you have #biochemistry expertise and want to join a world-class research environment, apply now! ✅ Global Talent Visa covered 📅 Apply by 09.01.26 👉 tinyurl.com/38rn6czz
hireful.
tinyurl.com
Goede voornemens voor 2026? Luister vanaf 2 januari naar Leef als een Naakte Molrat voor de laatste lifestylehacks uit de wetenschap over voeding, vasten, sport en mentale gezondheid. #podcast #lifehack #health #nutrition #fasting #fitness #mentalhealth
Interested in metabolomics/systems biology and aging in Drosophila? We have a post-doc opening! And of course, there will be plenty of opportunities for side projects on the @dogagingproject.bsky.social. 🐶 promislowlab.org/wp-content/u...
promislowlab.org
🔬#Postdoc position available: We are looking for new lab member to join our team working on Protein #Aggregation and #Ageing in Cambridge. Please spread the word. tinyurl.com/38rn6czz
hireful.
tinyurl.com
This includes a variant in cGAS, for which we subsequently showed it leads to a reduced function of the protein in cell lines from both humans and mice, which nicely complements earlier work on this protein in animal models. @molepi.bsky.social @marianbeekman.bsky.social @antebilab.bsky.social 🧬🧪
🚨Proud to present the latest preprint from our group, spearheaded by Pasquale Putter and the culmination of many years of work on the Leiden Longevity Study, in which we used multigenerational long-lived families to identify novel rare protein-altering genetic variants linked to ancestral longevity.
bioRxivpreprint@biorxivpreprint.bsky.social · 10mo agoRare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families https://www.biorxiv.org/content/10.64898/2025.12.04.689698v1
🚀 preprint alert: medrxiv.org/cgi/content/... 🧬 How important is genetic predisposition to chronic diseases for healthy survival up to later age?
Low Genetic Risk for Coronary Artery Disease underlies Multigenerational Longevity and Healthy Aging
Descendants of exceptionally long-lived families have a delayed onset of their first chronic disease. We therefore hypothesize that one of the key features explaining healthy survival up to high ages ...
medrxiv.org
