A scalable plate reader-based protocol to measure mitochondrial respiration in embryonic hearts

Mitochondrial function is central to embryonic development, yet its assessment in the embryonic heart is hampered by limited tissue availability. Here, we present a protocol to measure mitochondrial o...

cell.com

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue

Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tis.....

onlinelibrary.wiley.com

Molecular diversity of mitochondrial autophagy receptors: context-dependent effects in human health and disease - Cell Death Discovery

Cell Death Discovery - Molecular diversity of mitochondrial autophagy receptors: context-dependent effects in human health and disease

nature.com

Focusing on Diastolic Dysfunction to Achieve Consensus With the Term Diabetic Cardiomyopathy

Diabetic cardiomyopathy (DbCM) is commonly defined as ventricular dysfunction in a person living with diabetes in the absence of hypertension and/or corona

diabetesjournals.org

Myocardial energy metabolism in aging

The natural process of aging in humans often increases one’s risk for a number of chronic diseases, including type 2 diabetes (T2D), dyslipidemia, hypertension, and cardiovascular disease (CVD). It is...

oaepublish.com

Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release - Cell Death & Differentiation

Cell Death & Differentiation - Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release

nature.com

Uncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt

Taskin, Shankar, Peselj, et al. demonstrate that mitochondria possess an intrinsic surveillance system that senses mild oxidative stress and activates the UPRmt before damage signals reach the cytosol...

cell.com

Cyclophilin D at the Heart of Neonatal Hypoxia

sciencedirect.com

Advantages of Skeletal Muscle Preservation in Settings of Weight Loss

“Quality weight loss” can be distinguished from regular weight loss in that the skeletal muscle is preserved. This can be achieved pharmacologically, by inducing mechanisms that preserve or increase ....

onlinelibrary.wiley.com

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells - Nature Metabolism

This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preser...

nature.com

Not All Weight Loss Is Equal: Towards Muscle‐Preserving Therapies in Obesity

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onlinelibrary.wiley.com

Prolonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial - Nature Communications

The study showed in a placebo-controlled crossover design that 4-week treatment with β2-adrenergic agonist clenbuterol enhances insulin-stimulated glucose uptake in skeletal muscle but not brown adipo...

nature.com

Prolonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial - Nature Communications

The study showed in a placebo-controlled crossover design that 4-week treatment with β2-adrenergic agonist clenbuterol enhances insulin-stimulated glucose uptake in skeletal muscle but not brown adipo...

nature.com

Science | AAAS

science.org

Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro‐Regenerative Versus Maladaptive

Skeletal muscle accounts for approximately 40% of total body mass and is essential for locomotion, metabolic regulation and systemic homeostasis. Adipose tissue is increasingly recognized as an activ...

onlinelibrary.wiley.com

Structure-based design of p62-derived peptides that inhibit autophagy-associated readouts and enhance chemotherapy response in breast cancer cells

Rational drug design seeks small molecules, aptamers, or peptides to disrupt key cellular targets. Autophagy, crucial in tumor formation, dormancy, an…

sciencedirect.com

The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors

GLP-1 medicines are used to treat people with type 2 diabetes, obesity, and metabolic dysfunction-associated steatohepatitis (MASH). Here, Gonzalez-Rellan et al. demonstrate that semaglutide activates...

cell.com

Fibro-adipogenic progenitor cells from murine SMA muscles are intrinsically adipogenic | PNAS

Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by mutations in the SMN1 gene. Although classically viewed as a neurogenic dis...

tinyurl.com

Exercise as a therapeutic intervention for long-lasting and chronic diseases

While life expectancy has increased, the prevalence of lifestyle diseases has increased. Here, Febbraio and Pedersen discuss the concept of “exercise as medicine” for the treatment of lifestyle diseas...

cell.com

Class IIa HDACs Inhibition reverses diastolic dysfunction and Increase Energy Expenditure in a murine HFpEF model

Abstract. Heart failure (HF) with preserved ejection fraction (HFpEF) is the most rapidly growing cardiovascular disease worldwide, affecting up to 30 mill

academic.oup.com

biorxiv.org

Core principles of autophagy initiation mechanisms - Nature Structural & Molecular Biology

In this Review, Kotani and Nakatogawa discuss recent advances in our understanding of the molecular basis of autophagy induction and delineate how diverse mechanisms converge on core principles to ens...

nature.com

The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative - Nature Reviews Cardiology

In this Review, Khoury and colleagues examine the growing body of evidence demonstrating the benefits of screening for cardiovascular risk factors, including dyslipidaemia and high blood pressure, sta...

nature.com

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

nature.com

Function and regulation of the mitochondrial stress response - Nature Structural & Molecular Biology

In this review, the authors discuss and contextualize the cellular responses launched after mitochondrial stress and note the importance of the emerging understanding in applying this new knowledge in...

nature.com

Addressing the Lp(a) hypothesis: will lowering Lp(a) decrease the risk of cardiovascular events?

Nature Reviews Cardiology, Published online: 17 March 2026; doi:10.1038/s41569-026-01278-8Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are an important risk factor for several cardiovascular diseases. However, to date, elevated Lp(a) levels have not been directly targeted by clinicians because Lp(a) levels are almost entirely genetically determined and are comparatively resistant to standard lipid-lowering therapies. This unmet medical need might soon be addressed with the advent of potent Lp(a)-lowering therapies.

dlvr.it

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

nature.com

Incretin and Glucagon Signalling in MASLD and MASH: Integrating Metabolic Pathways With Disease Progression - PubMed

Metabolic dysfunction-associated steatotic liver disease (MASLD) arises from dysregulated interactions between nutrient delivery, adipose tissue lipid handling and liver lipid metabolism, which collectively coalesce to drive inflammatory signalling leading to metabolic dysfunction-associated steatoh …

pubmed.ncbi.nlm.nih.gov

The glycaemic response to morning fasted resistance exercise is more consistent than the response to afternoon fed resistance exercise for adults with type 1 diabetes: a randomised crossover compariso...

Aims/hypothesis People with type 1 diabetes are recommended to modify insulin dosing and/or carbohydrate intake before, during and after exercise to manage blood glucose levels and prevent hypoglycaem...

link.springer.com

Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity - Nature Communications

This multi-cohort study reports genetic variants in myostatin associated with increased muscle mass, strength, and reduced adiposity. These findings support long-term myostatin blockade for muscle pre...

nature.com