Finally mounted my patternmakers nice on the bench. Five axes!

Lovely day out in the Gulf.

Was browsing an antique book store in Houston this afternoon and found the treasure. 1959, at the cusp of the molecular biology revolution.

Does anyone know of a whitespace markup plugin for safari. You know, turns that pesky hidden text to red/green whatever?

Looks like the cold weather in Houston is over for now, so my best buddies are out of their cover and getting a tan again. The bigger ones should move out of the house later. But one of them flowered like crazy when moved inside.

I’m looking for a consultant for some part time remote work. Ideal profile would be 25+ years in med chem/pharmacology, remembers the mergers and acquisitions that happened in pharma and is a dab hand at navigating research codes like CS-045, CI-911 and GR-92132X. If this sounds fun, get in touch!

Spent the early part of the afternoon curating some of the Lego and framing the new portrait.

The BBC news site is usually great, but I wish that health stories were better proof read and verified. For example, this article mentions the gas nitric acid www.bbc.com/future/artic... of course, it should be nitric oxide.

The surprising benefits of a glass of orange juice

The habit of drinking a glass of orange juice can have a considerable effect on your health.

bbc.com

Went to Barnes and Noble today to buy some Xmas presents for the family. Ended up getting me a present instead. It is a superb book so far.

Today I have mostly been sorting the garage.

Apparently it’s 48 years ago since New Boots and Panties was released. A true classic album, survived the test of time for sure!

For self conscious pseudo-intellectual teenagers from post-industrial Britain in the 1980s this is big news. For the rest of the world - nothing to see here.

I finished my estimate on required compute to make an atomic-resolution virtual cell: 10^38 FLOPs to simulate a human cell for 1 day. We should be able to do this simulation in 2074 using 200 TW of power. 1/3

Nostalgia ain’t what it used to be. Just found a microfiche. Big stack of these. If only I had the reader. I bet they’re museum pieces now.

Just sorting through some old files. Really fun to step back in time. This must have been 1988 or so. Acetates, permanent markers. None of your AI assistants in putting this together. And it shows 😂😂

As a Brit expat in the States, it’s sad to see that access to the BBC News website is now paywalled. $90 a year!

It’s August in our home, and that means getting ready for Halloween!! The theme this year (apparently) is Labyrinth - here is David Bowie.

A sort of nerdy question around licenses. Imagine I subscribe to a journal in which they don’t allow text mining on the content. Seems fair. But if is store the pdf locally, then my Mac will index it and allow full text searching. Does this count as text mining?

Getting frustrated with the number of resources that disappear, change terms of use, etc. Seems cheeky that people publish in places like NAR Database with an 'open' resource, then flip to closed. Tempted to put together a table of all the NAR DB resources and plot existence/current license....

And while I’m thinking of Nature, their typography has gone downhill. The spacing between words in titles is now atrocious! Defense against OCR LLM tokenization or just poor visual design? 🤣

Bit of an insult for Nature magazine in the Google response to asking if fake patents and fake publications are different.

The times they are a changin’.

RCSB Protein Data Bank@rcsbpdb.bsky.social · last yr.

Transitioning to PDBx/mmCIF and Extended PDB IDs PDB users are strongly encouraged to make changes to software; use the full 12-character ID in all communications; and encourage others to adopt ASAP Details at wwPDB: www.wwpdb.org/news/n...

CASP is the main reason the protein structure prediction technology and research field advanced over the last 30 years. And the main reason AI based methods have been accepted and widely applied in biology. So shortsighted of NIH to postpone or even halt funding. John Moult is a scientific hero.

Science Magazine@science.org · last yr.

Exclusive: An international scientific competition widely credited with spurring the development of artificial intelligence for biology appears to be on its deathbed. scim.ag/44ukS90

That's it. It's done. I am no longer on the other place. I'm going to miss some of the science on there, and in particular the biotech analyst community seems stuck there, but enough was enough. It had to go.

Is there anywhere online a free lexicon for alternate spelling of scientific terms between US and UK English. Something that contains the equivalence of sulphotransferase = sulfotransferase, protease = proteinase, etc. But also smart to know that synthase and synthetase are different concepts.

UI oddity of the day - a box to ask if I'm human, which looks like the only option I have is to click to say no, turns out it's a slider hiding as a tick box.

Waiting.

It’s my son’s birthday, so we are at a Metallica concert.

Anyone interested in some paid freelance writing on AI in drug discovery for drughunter.com - if so get in touch for more details !

Drug Hunter - drug discovery, distilled

Drug Hunter is for drug discovery scientists who want to discover new ideas but don't have time to read everything.

drughunter.com