Jeff Rasmussen

@jraslab.bsky.social

We study skin-neuron interactions in #zebrafish. Located in beautiful #Seattle (UW Biology). Join us! #devbio #organogenesis #regeneration Lab website: https://jraslab.org

We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!

Early visual experience elicits cellular and functional plasticity in the retina and alters behavior

The understanding of experience-dependent plasticity in the vertebrate retina is largely incomplete. Reynolds et al. discovered that raising animals in differently patterned visual environments change...

cell.com

Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. www.biorxiv.org/content/10.6... Huge thanks to my PI, @ohnolog.bsky.social ! 🧵

Early immune cell development precedes gastrulation in annual killifish

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

biorxiv.org

We are looking for science writers to write a “Science Spotlight” mini-review of a recent high-impact zebrafish paper for the next issue of the IZFS @izfs.bsky.social News Splash. For this mentored science writing experience, DM me and we can start working together!

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Latest paper from the lab! 👀 Check out this macrophage (labeled with a microtubule reporter in blue) avoid an epithelial obstacle (labeled with a nuclear reporter in pink) as it migrates to a wound (off screen to the left) ⬅️ Video credit: @errricpeterman.bsky.social

Journal of Cell Science@jcellsci.bsky.social · 11mo ago

Eric Peterman @errricpeterman.bsky.social, Jeffrey Rasmussen @jraslab.bsky.social @uwbiology.bsky.social & colleagues discover that microtubules regulate tissue-level navigation in skin-resident macrophages. journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Congrats to @errricpeterman.bsky.social on leading our latest paper now published in @jcellsci.bsky.social ! Eric found multiple roles for microtubules in tissue-resident macrophage homeostasis and function -- including in helping macrophages navigate around epithelial obstacles during wound repair👇

Eric Peterman@errricpeterman.bsky.social · 11mo ago

now online! check out our work describing roles for microtubules in tissue-resident macrophages during directed cell migration. thanks to @jcellsci.bsky.social for a stress-free publication process journals.biologists.com/jcs/article/...

Microtubules in a skin-resident macrophage

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Fred Hutchinson Cancer Center

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

careers-fhcrc.icims.com