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Mike Dorrity

@mwdorr.bsky.social

Group Leader at EMBL Heidelberg. temperature, single cell genomics, proteins, and lots of fish.

29 Posts1192 Follower1588 Folgt
Jay Shendure@jshendure.bsky.social · 5d ago

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

Gaurav Vaidya@gvaidya.bsky.social · last mo.

The first preprint from my PhD is out! :thread: How does an animal choose between two completely different reproductive fates? Here’s how one planarian does it :point_down: www.biorxiv.org/content/10.6...

Life-cycle trajectory inference links temperature-gated progenitors to reproductive fate

Temperature shapes reproductive strategies across animals, yet how individuals switch between sexual and asexual reproduction remains unknown. We establish the planarian Phagocata morgani as a model f...

biorxiv.org

Mike Dorrity@mwdorr.bsky.social · last mo.

First preprint stemming from a fantastic collaboration with @hanhtkvu.bsky.social Shared PhD student and BIF fellow @gvaidya.bsky.social led this tour de force - check it out ! How does temperature affect whole-organism cellular trajectories?

Gaurav Vaidya@gvaidya.bsky.social · last mo.

The first preprint from my PhD is out! :thread: How does an animal choose between two completely different reproductive fates? Here’s how one planarian does it :point_down: www.biorxiv.org/content/10.6...

Syd Sattler@sydsat.bsky.social · last mo.

What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. www.biorxiv.org/content/10.6... Huge thanks to my PI, @ohnolog.bsky.social ! 🧵

Early immune cell development precedes gastrulation in annual killifish

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

biorxiv.org

Nicoletta Petridou@nicolettapetridou.bsky.social · last mo.

Double preprint! 👇 Check out our latest studies on timing, heterogeneity and collective behaviour (with a fun tiny bonus on evolution!) 1. www.biorxiv.org/content/10.6... 2. arxiv.org/abs/2605.13234

Cellular timing heterogeneity regulates phase transitions in living matter

Rigidity transitions govern tissue organization in ways reminiscent of inert materials. Yet, living tissues are composed of active units with autonomous timing mechanisms, raising the question whether...

biorxiv.org

Lena Schindler@lena-schindler.bsky.social · last mo.

I am thrilled to share my PhD work with @nicolettapetridou.bsky.social @embl.org: www.biorxiv.org/cgi/content/... A fun collaboration with Bernat Corominas-Murtra, Adrián Aguirre-Tamaral, @bart-smeets.bsky.social , Jef Vanghel and Tom Belpaire! Read the story in the comments below ⤵️

Mike Dorrity@mwdorr.bsky.social · 2mo ago

First pre-print from the lab, a collaborative effort led by Jess Bourn @bournsupremacy.bsky.social, a fantastic PhD in my group. We resolve a key problem in development + evolution: how do we quantify heterochrony and link temporal variation to phenotype? www.biorxiv.org/content/10.6...

Quantitative mapping of heterochrony to species-specific phenotypes

The genetic program of animal development is conserved, but its rate of execution varies across species. Heterochrony, shifts in the relative timing of developmental events, generates phenotypic varia...

biorxiv.org

James Gagnon@james-gagnon.bsky.social · 2mo ago

Excited to share the published version of MIC-Drop-seq @natcomms.nature.com! Shoutout to co-lead authors @claycarey.bsky.social @sparvez.bsky.social for driving this work. Excited to see where this new scale of single-cell perturbation screening goes next. www.nature.com/articles/s41...

James Gagnon@james-gagnon.bsky.social · last yr.

To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals. For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq. www.biorxiv.org/content/10.1...

Arnaud Krebs@arnaudkr.bsky.social · 4mo ago

Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org

Michela Palamin@mpalamin.bsky.social · 4mo ago

ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️

Mike Dorrity@mwdorr.bsky.social · 5mo ago

The time has come for another round of QBMM - we have a fantastic lineup of speakers in genomics, systems biology, and modeling cell dynamics. Check it out! Co-orgs @elowitzlab.bsky.social @tinekelenstra.bsky.social @trayon.bsky.social @savitski-lab.bsky.social and I look forward to seeing you

EMBL Events@events.embl.org · 5mo ago

Join #EMBOOmics which aims to showcase new technologies and formulate questions to move the systems biology field forward 👉 s.embl.org/omx26-01-bl 📥 Abstract deadline 11 September

Ewan Birney@ewanbirney.bsky.social · 11mo ago

Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader – AI in Biology

Are you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine...

embl.wd103.myworkdayjobs.com

Mike Dorrity@mwdorr.bsky.social · 11mo ago

Very excited to share - the ERC StG is a game-changer for us 🙏 We're going to learn the rules for timing control across cell types in the embryo and we think we can tune them too 🎛️ ⏳📈- reach out if you’d like to be involved !

European Research Council (ERC)@erc.europa.eu · 11mo ago

📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope

Mike Dorrity@mwdorr.bsky.social · 12mo ago

EMBL is an amazing place to start a lab and bring new direction to your research program (ask me how I know) - come join us in Heidelberg !

Eileen Furlong@eileen-furlong.bsky.social · last yr.

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Eileen Furlong@eileen-furlong.bsky.social · last yr.

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader - Genome Biology Unit

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

embl.wd103.myworkdayjobs.com

Typas Lab@typaslab.bsky.social · last yr.

Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!

Group Leader – Molecular Systems Biology Unit

Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...

embl.wd103.myworkdayjobs.com

Ewan Birney@ewanbirney.bsky.social · last yr.

We have updated our preprint on GxE and epipstatic interactions in vertebrates, lead authors Bettina Welz and @saulpierotti.bsky.social, a collaboration between my lab, @wittbrodtlab.bsky.social, Felix Loosli and Kiyoshi Naruse's lab. www.biorxiv.org/content/10.1...

Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model

Phenotypic variation arises from the interplay between genetic and environmental factors. However, disentangling these interactions for complex traits remains challenging in observational cohorts such...

biorxiv.org

@kausthubh.bsky.social · last yr.

I attended the exciting symposium organized by @floravincent.bsky.social @mwdorr.bsky.social, @nicoledubilier.bsky.social, @gautamdey.bsky.social & Susanna Coelho LOTs of takeaways from the Symposium (from biology to climate change) 🚨Here are a few important ones in my listicle below 👇

Biology beyond conventional model organisms – a whole new world | EMBL

An EMBL | EMBO symposium explored the ‘wild frontiers’ of model organisms, from phytoplankton to sea anemones, waterstriders, roundworms, and more.

embl.org

EMBL@embl.org · last yr.

With rapid changes in our environment and climate, there's an urgent need to better understand living systems and their interactions, going beyond the few well-established ‘model’ organisms. A recent EMBO | EMBL Symposium explored how we might do that. Learn more: www.embl.org/news/science...

Neil Shubin@neilshubin.bsky.social · last yr.

New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...

Teeth first evolved as sensory tissue in the armored exoskeletons of ancient fish, fossil scans find

Anyone who has ever squirmed through a dental cleaning can tell you how sensitive teeth can be. This sensitivity gives important feedback about temperature, pressure—and yes, pain—as we bite and chew ...

phys.org

Mike Dorrity@mwdorr.bsky.social · last yr.

Thanks for all the great discussions - @msarscentre.bsky.social is a one-of-kind research environment ! and very sunny in my limited sampling..

Michael Sars Centre@msarscentre.bsky.social · last yr.

How does temperature impact development? 🌡️ Michael Dorrity @mwdorr.bsky.social from @embl.org shared his integrated approach to revealing the relationship between temperature stress and developmental rate in fishes 🐟🐠 Thank you for a great talk and discussions! 👏

A man faces an audience in a seminar room, speaking. On a screen behind him, a slide with an image of a fish embryo, and the caption "you could just record developing embryos..."